Functional brain imaging with a supercontinuum time-domain NIRS system

Selb, Juliette; Zimmermann, Bernhard; Martino, Mark; Ogden, Tyler M.; Boas, David A.

doi:10.1117/12.2005348

Cited by 7 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular the most active in the field are the research groups at Physikalisch-Technische Bundesanstalt, Berlin, Germany [9][10][11][12][13][14][15], at the Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland [16][17][18], and at the the Department of Medical Physics and Bioengineering, University College London [19][20][21][22][23]. In the US we can mention the group at the Massachusetts General Hospital, Athinoula A. Martinos Center, Charlestown, Massachusetts [6,[24][25][26]. In Canada we can mention the group at the University of Western Ontario, Department of Medical Biophysics London, Ontario [27].…”

Section: Introductionmentioning

confidence: 99%

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Re¹,

Contini²,

Turola³

et al. 2013

Biomed. Opt. Express

View full text Add to dashboard Cite

Abstract:We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment. ©2013 Optical Society of America

show abstract

Section: Introductionmentioning

confidence: 99%

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Re¹,

Contini²,

Turola³

et al. 2013

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…This has been done by comparing the time-independent signal of the IRF at all the detectors when only one detector was illuminated. Moreover, we measured the dynamic range of our measurement to be of 3 orders of magnitude, which is in the range of previously reported systems [38]. Table 2 summarized the main system characterization.…”

Section: Crosstalk and Dynamic Rangementioning

confidence: 65%

“…Hence, to characterize the gate's stability more precisely, we recorded the IRF each hour for 8 h after the 2 h of warm-up. We focused on two parameters: the FWHM and the mean arrival time of the photons [38]. The mean arrival time of the photons, which illustrates the position of the gate, demonstrated a large variation of about 130 ps across 8 h. This would be problematic for a long acquisition time, as it would induce a drift in the recorded data.…”

Section: B Warm-up Time and Stability Of The Systemmentioning

confidence: 99%

Broadband time-resolved multi-channel functional near-infrared spectroscopy system to monitor in vivo physiological changes of human brain activity

Lange¹,

Peyrin²,

Montcel³

2018

Appl. Opt.

View full text Add to dashboard Cite

We have developed a broadband time-resolved multi-channel near-infrared spectroscopy system that can monitor the physiological responses of the adult human brain. This system is composed of a supercontinuum laser for the source part and of an intensified charge-coupled device camera coupled with an imaging spectrometer for the detection part. It allows the detection of the spectral, from 600 to 900 nm, and spatial dimensions as well as the arrival time of photon information simultaneously. We describe the setup and its characterization in terms of temporal instrument response function, wavelength sensitivity, and stability. The ability of the system to detect the hemodynamic response is then demonstrated. First, an in vivo experiment on an adult volunteer was performed to monitor the response in the arm during a cuff occlusion. Second, the response in the brain during a cognitive task was monitored on a group of five healthy volunteers. Moreover, looking at the response at different time windows, we could monitor the hemodynamic response in depth, enhancing the detection of the cortical activation. Those first results demonstrate the ability of our system to discriminate between the responses of superficial and deep tissues, addressing an important issue in functional near-infrared spectroscopy.

show abstract

“…These laser sources, unlike the Ti:sapphire lasers, are compact and suitable for a portable system, 86,87 and also wavelength selection can be performed more rapidly. These laser sources, unlike the Ti:sapphire lasers, are compact and suitable for a portable system, 86,87 and also wavelength selection can be performed more rapidly.…”

Section: Light Sourcesmentioning

confidence: 99%

New frontiers in time-domain diffuse optics, a review

et al. 2016

View full text Add to dashboard Cite

The recent developments in time-domain diffuse optics that rely on physical concepts (e.g., time-gating and null distance) and advanced photonic components (e.g., vertical cavity source-emitting laser as light sources, single photon avalanche diode, and silicon photomultipliers as detectors, fast-gating circuits, and time-to-digital converters for acquisition) are focused. This study shows how these tools could lead on one hand to compact and wearable time-domain devices for point-of-care diagnostics down to the consumer level and on the other hand to powerful systems with exceptional depth penetration and sensitivity.

show abstract

Functional brain imaging with a supercontinuum time-domain NIRS system

Cited by 7 publications

References 12 publications

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Broadband time-resolved multi-channel functional near-infrared spectroscopy system to monitor in vivo physiological changes of human brain activity

New frontiers in time-domain diffuse optics, a review

Contact Info

Product

Resources

About