New frontiers in time-domain diffuse optics, a review

Pifferi, Antonio; Contini, Davide; Mora, Alberto Dalla; Farina, Andrea; Spinelli, Lorenzo; Torricelli, Alessandro

doi:10.1117/1.jbo.21.9.091310

Cited by 214 publications

(212 citation statements)

References 189 publications

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“…In addition, the possibility to obtain wearable instruments is suitable for all the steps of the rehabilitation processes or sport training, where a monitoring of the muscular tissue hemodynamic progress is necessary. 27 As discussed in Sec. 3.4, for the future, it is necessary to properly address the issue of the thermal stability of the detection probe, in particular by employing proper heat management strategies due to the presence of the radiofrequency avalanche signal amplifier.…”

Section: Discussionmentioning

confidence: 97%

Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom andin vivotests

Martinenghi

Mora

et al. 2016

Neurophoton

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Abstract. We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders. The SiPM is inserted into a transparent and insulating resin to avoid the direct contact of the scalp with the 100-V bias voltage. The probe was integrated in an instrument for TD fNIRS spectroscopy. The system was characterized on tissue phantoms in terms of temporal resolution, responsivity, linearity, and capability to detect deep absorption changes. Preliminary in vivo tests on adult volunteers were performed to monitor hemodynamic changes in the arm during a cuff occlusion and in the brain cortex during a motor task.

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Section: Discussionmentioning

confidence: 97%

Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom andin vivotests

Martinenghi

Mora

et al. 2016

Neurophoton

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“…An insightful simulation of measurements performed at radius distal location was presented, investigating the potential for in vivo studies in the 1100-to 1700-nm range. Improving instrument sophistication (e.g., integrated circuit solutions for InGaAs/ InP SPAD under development 37 ) will guarantee strong cost and size reduction in the near future, making miniature handheld technologies available, 5 and we see point of care devices as one of the possible beneficiary to use these long-wavelength spectral features at in situ conditions.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3][4] Traditionally, in vivo diffuse optical measurements have been performed, at most, in the 600-to 1100-nm window. [5][6][7] This is due to high hemoglobin absorption below 600 nm and dominant water absorption combined with lack of suitable detection technology above 1100 nm. Furthermore, studies are most often performed below 900 nm, where more conventional and cheaper detectors are available.…”

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confidence: 99%

Diffuse optical characterization of collagen absorption from 500 to 1700 nm

et al. 2017

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Abstract. Reduction in scattering, high absorption, and spectral features of tissue constituents above 1000 nm could help in gaining higher spatial resolution, penetration depth, and specificity for in vivo studies, opening possibilities of near-infrared diffuse optics in tissue diagnosis. We present the characterization of collagen absorption over a broadband range (500 to 1700 nm) and compare it with spectra presented in the literature. Measurements were performed using a time-domain diffuse optical technique. The spectrum was extracted by carefully accounting for various spectral distortion effects, due to sample and system properties. The contribution of several tissue constituents (water, lipid, collagen, oxy, and deoxy-hemoglobin) to the absorption properties of a collagen-rich in vivo bone location, such as radius distal in the 500-to 1700-nm wavelength region, is also discussed, suggesting bone diagnostics as a potential area of interest.

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“…14,15 During the last two decades, picosecond pulsed lasers, time-resolved singlephoton detectors, and time-tagging electronics have experienced considerable advancements, but the state-of-the-art TD-DOT systems like MONSTIR 16,17 and other instruments 18,19 are still large rack-based systems, limiting somewhat a widespread clinical adoption. In particular, since DOT requires a large number of detection points (e.g., few tens), the main bottleneck is still represented by the use of expensive, bulky, and delicate photocathode-based vacuum tubes like photomultiplier tubes (PMTs) or, more recently, hybrid PMTs.…”

Section: Introductionmentioning

confidence: 99%

Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study

et al. 2016

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Abstract. Silicon photomultipliers (SiPMs) have been very recently introduced as the most promising detectors in the field of diffuse optics, in particular due to the inherent low cost and large active area. We also demonstrate the suitability of SiPMs for time-domain diffuse optical tomography (DOT). The study is based on both simulations and experimental measurements. Results clearly show excellent performances in terms of spatial localization of an absorbing perturbation, thus opening the way to the use of SiPMs for DOT, with the possibility to conceive a new generation of low-cost and reliable multichannel tomographic systems. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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New frontiers in time-domain diffuse optics, a review

Cited by 214 publications

References 189 publications

Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom andin vivotests

Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom andin vivotests

Diffuse optical characterization of collagen absorption from 500 to 1700 nm

Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study

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