Functional capacity, pulmonary function, and quality of life in hematopoietic stem cell transplantation survivors

Penna, Giana Berleze; Silva, Tassiana Costa da; Paz, Alessandra Aparecida; Ziegler, Bruna

doi:10.1007/s00520-020-05947-3

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…In contrast, Penna et al . [ 8 ] found that less active or physically disabled survivors presented inferior PFT values and poor performance on the 6-minute walking (6MW) test. In their study, the most physically active individuals had the most optimal FEV 1 (L), FEV 1 (% from the expected), and FEV1/FVC (absolute), and walked longer distances on the 6MW test.…”

Section: Discussionmentioning

confidence: 99%

The Role of Pre-bone Marrow Transplantation Pulmonary Function Test in Predicting Post-transplant Noninfectious Pulmonary Complications

Ahmed,

Gassas,

Ahmed

et al. 2023

Saudi Journal of Medicine &Amp; Medical Sciences

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Background: Pulmonary function test (PFT) is used as a tool for pre-transplant risk assessment and as a predictor of post-transplant outcomes. As there are currently few studies that discuss the role of PFT in bone marrow transplantation (BMT) patients in Saudi settings, and as the number of transplant patients with benign and malignant conditions continues to increase, this study was conducted with the aim of assessing the local practice. Methods: This retrospective cohort study included all adult patients who underwent BMT at Princess Noorah Oncology Center, King Abdulaziz Medical City, Jeddah, between 2014 and 2020. The association between established patient-related risk factors and the incidence of pulmonary complications among autologous and allogeneic groups was assessed. Results: A total of 186 patients were included (autologous = 143; allogenic = 43), of which 115 (61.8%) were male. At the pre-BMT phase, about 30% of the patients had comorbidities and 51% had received two rounds of salvage chemotherapy, while 16.1% had received radiation therapy. In the autologous group, the only PFT parameter that was a significant predictor of post-BMT pulmonary complications was forced vital capacity <80% ( P = 0.012), while in the allogenic group, no parameter was significantly associated with pulmonary complications. The patient-related factors that were associated with respiratory distress in the autologous group were lung involvement ( P = 0.03) and pre-transplant radiation ( P = 0.044). Conclusion: The findings of this study indicated that forced vital capacity <80% was a significant factor in predicting non-infectious complications in the autologous group. Furthermore, lung involvement and pre-transplant radiation were the patient-related factors associated with pulmonary complications.

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Section: Discussionmentioning

confidence: 99%