Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease

Cerasa, Antonio; Hagberg, Gisela E.; Peppe, Antonella; Bianciardi, Marta; Gioia, Maria Cecilia; Costa, Alberto; Castriota-Scanderbeg, Alessandro; Caltagirone, Carlo; Sabatini, Umberto

doi:10.1016/j.brainresbull.2006.09.014

Cited by 121 publications

(118 citation statements)

References 51 publications

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“…This might be because the mid-insula is implicated in the processing of position, movement, and sensation of the body (Cerasa et al, 2006; Chang et al, 2013). The UPDRS-III and the motor subscores may not closely reflect the function of mid-insula when patients are in an on medication state.…”

Section: Discussionmentioning

confidence: 99%

Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson’s Disease

Koshimori

Cho

Criaud

et al. 2016

Front. Aging Neurosci.

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The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson’s disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Resting-state functional MRI data of a total of 65 participants, including 23 healthy controls (HCs) and 42 patients, were investigated in 120 nodes for local efficiency, betweenness centrality, and degree. Hub regions were identified in the HC and patient groups. We found nodal and hub changes in patients compared with HCs, including the right pre-supplementary motor area (SMA), left anterior insula, bilateral mid-insula, bilateral dorsolateral prefrontal cortex (DLPFC), and right caudate nucleus. In general, nodal regions within the sensorimotor network (i.e., right pre-SMA and right mid-insula) displayed weakened connectivity, with the former node associated with more severe bradykinesia, and impaired integration with default mode network regions. The left mid-insula also lost its hub properties in patients. Within the executive networks, the left anterior insular cortex lost its hub properties in patients, while a new hub region was identified in the right caudate nucleus, paralleled by an increased level of inter- and intra-connectivity in the bilateral DLPFC possibly representing compensatory mechanisms. These findings highlight the diffuse changes in nodal organization and regional hub disruption accounting for the distributed abnormalities across brain networks and the clinical manifestations of PD.

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Section: Discussionmentioning

confidence: 99%

Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson’s Disease

Koshimori

Cho

Criaud

et al. 2016

Front. Aging Neurosci.

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“…Cerebellar dysfunction restricts aftereffects during de-adaptation after SBT walking [37]; however, persons with PD do not uniformly demonstrate cerebellar hypoactivity. Rather, the cerebellum has instead been found to be hyperactive during movement in PD when OFF meds [38–40]. As reduction in cerebellar inhibition of the motor cortex is essential to the storage of SBT aftereffects [15], it is possible that the cerebellar hyperactivity observed in PD when OFF meds could diminish aftereffect storage.…”

Section: Discussionmentioning

confidence: 99%

Effects of dopaminergic therapy on locomotor adaptation and adaptive learning in persons with Parkinson's disease

Roemmich

Hack

Akbar

et al. 2014

Behavioural Brain Research

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Persons with Parkinson’s disease (PD) are characterized by multifactorial gait deficits, though the factors which influence the abilities of persons with PD to adapt and store new gait patterns are unclear. The purpose of this study was to investigate the effects of dopaminergic therapy on the abilities of persons with PD to adapt and store gait parameters during split-belt treadmill (SBT) walking. Ten participants with idiopathic PD who were being treated with stable doses of orally-administered dopaminergic therapy participated. All participants performed two randomized testing sessions on separate days: once while optimally-medicated (ON meds) and once after 12-hour withdrawal from dopaminergic medication (OFF meds). During each session, locomotor adaptation was investigated as the participants walked on a SBT for ten minutes while the belts moved at a 2:1 speed ratio. We assessed locomotor adaptive learning by quantifying: 1) aftereffects during de-adaptation (once the belts returned to tied speeds immediately following SBT walking) and 2) savings during re-adaptation (as the participants repeated the same SBT walking task after washout of aftereffects following the initial SBT task). The withholding of dopaminergic medication diminished step length aftereffects significantly during de-adaptation. However, both locomotor adaptation and savings were unaffected by levodopa. These findings suggest that dopaminergic pathways influence aftereffect storage but do not influence locomotor adaptation or savings within a single session of SBT walking. It appears important that persons with PD should be optimally-medicated if walking on the SBT as gait rehabilitation.

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“…Studies suggest that cueing may stimulate alternative cortical pathways (eg, visual motor pathways) 32 to bypass the basal ganglia, whereas other studies suggest that cueing synchronizes the simultaneous timing of interlimb coordination in the cerebellum needed for normal gait. 33,34 Further studies are needed to investigate the neurophysiological mechanisms underpinning the effectiveness of rhythmic cueing in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Does Cueing Training Improve Physical Activity in Patients With Parkinson’s Disease?

Lim

Wegen

Jones

et al. 2010

Neurorehabil Neural Repair

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Background. Patients with Parkinson's disease (PD) are encouraged to stay active to maintain their mobility. Ambulatory activity monitoring (AM) provides an objective way to determine type and amount of gait-related daily activities. Objective. To investigate the effects of a home cueing training program on functional walking activity in PD. Methods. In a single-blind, randomized crossover trial, PD patients allocated to early intervention received cueing training for 3 weeks, whereas the late intervention group received training in the following 3 weeks. Training was applied at home, using a prototype cueing device. AM was applied at baseline, 3, 6, and 12 weeks in the patient's home, to record body movements. Postures and motions were classified as percentage of total time spent on (a) static activity, further specified as % sitting and % standing, and (b) % dynamic activity, further specified as % walking, % walking periods exceeding 5 seconds (W>5s) and 10 seconds (W> 1 0s). Random coefficient analysis was applied. Results. A total of 153 patients participated in this trial. Significant improvements were found for dynamic activity (b = 4.46; P < .01), static activity (b = -3.34; P < .01), walking (b = 4.23; P < .01), W>5s (b = 2.63; P < .05), and W> 1 0s (b = 2.90; P < .01). All intervention effects declined significantly at 6 weeks follow-up. Conclusion. Cueing training in PD patients' own home significantly improves the amount of walking as recorded by AM. Treatment effects reduced after the intervention period, pointing to the need for permanent cueing devices and follow-up cueing training.

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Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease

Cited by 121 publications

References 51 publications

Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson’s Disease

Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson’s Disease

Effects of dopaminergic therapy on locomotor adaptation and adaptive learning in persons with Parkinson's disease

Does Cueing Training Improve Physical Activity in Patients With Parkinson’s Disease?

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