Functional characteristics of calcium-sensitive adenylyl cyclase of the infusorian Tetrahymena pyriformis

Derkach, K. V.; Ao, Shpakov; Uspenskaya, Z. I.; Yudin, A. L.

doi:10.1134/s1990519x10060106

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…The adenylyl cyclase seems to be a highly unique subtype of this enzyme group, which is restricted to ciliates [88]. The cyclic AMP formation by the enzyme is influenced by the Ca 2+ and K + content [89,90] and by biogenic amines [91], natural amino acids [92], and by hormones, e.g. epidermal growth factor [93], epinephrine, insulin, glucagon, as well as the cPDE blocker theophylline [94,95].…”

Section: Signal Transduction and Second Messengers Of Tetrahymenamentioning

confidence: 99%

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

Csaba

2012

Acta Microbiologica Et Immunologica Hungarica

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The unicellular ciliate, Tetrahymena has receptors for hormones of the higher ranked animals, these hormones (e.g. insulin, triiodothyronine, ACTH, histamine, etc.) are also produced by it and it has signal pathways and second messengers for signal transmission. These components are chemically and functionally very similar to that of mammalian ones. The exogenously given hormones regulate different functions, as movement, phagocytosis, chemotaxis, cell growth, secretion, excretion and the cells' own hormone production. The receptors are extremely sensitive, certain hormones are sensed (and response is provoked) at 10-21 M concentration, which makes likely that the function could work by the effect of hormones produced by the Tetrahymena itself. The signal reception is selective, it can differentiate between closely related hormones. The review is listing the hormones produced by the Tetrahymena, the receptors which can receive signals and the signal pathways and second messengers as well, as the known effects of mammalian hormones to the life functions of Tetrahymena. The possible and justified role of hormonal system in the Tetrahymena as a single cell and inside the Tetrahymena population, as a community is discussed. The unicellular hormonal system and mammalian endocrine system are compared and evolutionary conclusions are drawn.

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Section: Signal Transduction and Second Messengers Of Tetrahymenamentioning

confidence: 99%

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

Csaba

2012

Acta Microbiologica Et Immunologica Hungarica

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“…In Flagellata there are many isoforms of adenylyl cyclases that pierce membrane once or several times and are involved in regulation of maturation, motility, and virulence of these unicellulars. Earlier we, in other representatives of lower eukaryots, free living infusoria Tetrahymena pyriformis and Dileptus anser, revealed and characterized the membrane-bound AC forms sensitive to calcium cations, hormones of higher vertebrate animals, some amino acids, nucleotides, and sugars [114][115][116][117][118][119]. Many biochemical and physiological processes in infusoria are shown to be regulated through the cAMP-dependent signaling cascades that have features of similarity with those in cells of higher eukaryotes, including spermatozoa.…”

Section: Resultsmentioning

confidence: 99%

Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa

Derkach

2014

J Evol Biochem Phys

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The cAMP-dependent signaling cascades play the key role in regulation of fertility of spermatozoa. Synthesis of cAMP in spermatozoa is realized both by soluble, and by transmembrane (membrane-bound) forms of adenylyl cyclases (AC). For the recent years numerous data appeared about the presence in spermatozoa at different stages of their maturation of a wide spectrum isoforms of membrane-bound AC and their regulation by hormones and hormone-like substances via the coupled to B-proteins receptors (GPCR). Agonists of GPCR in spermatozoa can be adenosine, biogenic amines, peptide hormones, odorants. Study of structural-functional organization and regulatory properties of AC of the signal system in spermatozoa is of great practical significance for reproductive technologies, as via the membrane-bound AC forms and signal cascades there are controlled such processes as motility and chemotaxis of spermatozoa, their capability for capacitation acrosomal reaction. In the review there are summarized and analyzed data on functioning and role of AC of signal system in spermatozoa of human and vertebrate animals and are discussed achievements and unsolved problems in this field.

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“…At first a ciliary and cortical localisation was seen, which later became diffuse within the cytoplasm, with a peri‐nuclear dominance (Kőhidai et al, ). In the insulin‐treated cells, Ca 2+ , which is also a second messenger, acts first by influencing adenylyl or guanylyl cyclases, with the participation of calmodulin (Kovács and Csaba, , ; Kovács et al, ; Derkach et al, ; Shemarova, ). The insulin‐binding capacity of the cells is also influenced by the Ca 2+ level of the cells, which shows continuous fluctuation (Kovács and Csaba, ).…”

Section: Insulin Insulin Receptors and Signal Pathways In Tetrahymenamentioning

confidence: 99%

Insulin at a unicellular eukaryote level

Csaba

2013

Cell Biology International

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The unicellular ciliate, Tetrahymena, has been the main model for studying the hormonal system of unicellular animals. Tetrahymena produce, store, secrete and take up insulin, the hormone being similar to that of mammals, both immunocytochemically and functionally. The plasma membrane and nuclear envelope of Tetrahymena have insulin receptors, which are structurally similar to the mammalian receptor, as it their binding capacity. The cell has also second messengers and signal pathways for insulin. Insulin influences the synthesis of other hormones. The first short encounter between the cell and insulin provokes the hormonal imprinting that alters the function of the cells and is transmitted to the progeny, and can persist for over 1,000 generations, in hormone binding, hormone content, phagocytosis, cell growth and movement. Insulin has a survival function in Tetrahymena and during stress insulin production and binding are elevated. Other protozoa also react to insulin, and the evolutionary aspects are discussed in this review since it is still not appreciated that the hormones are of great antiquity in the animal kingdom.

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Functional characteristics of calcium-sensitive adenylyl cyclase of the infusorian Tetrahymena pyriformis

Cited by 6 publications

References 19 publications

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa

Insulin at a unicellular eukaryote level

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