Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy

Abstract

Aim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under infl uence of statin therapy. Methods and results. In 20 patients endothelium-dependent vasodilation (EDVD) has been detected based on reactive hyperemia and its dynamics depending on the body mass index under the infl uence of statin therapy. Conclusion. In patients with ischemic heart disease, obesity and NAFLD fi rst degree expressed positive dynamics on endothelial function (57%) in contrast to patients with overweight (44%) has been revealed during therapy with pitavastatin 2 mg for 8 weeks; besides an increase of hepatic transaminases has not been detected, which means that the abolition of the drug was not required.

Vascular endothelial growth factor as a marker of endothelial dysfunction in poly- and comorbidity: focus on hypertension, type 2 diabetes mellitus and subclinical hypothyroidism

“…In recent years studies have convincingly proved an important and independent role of the endothelium in the development of cardiovascular (CV) diseases. It plays an extremely important role in the development of atherosclerotic changes in the vascular wall, vessel remodeling and angiogenesis [1,2]. Endothelial dysfunction (ED) has proved to be associated with a large number of different factors and pathological conditions such as age, postmenopause, hypercholesterolemia and hypertriglyceridemia, diabetes mellitus, smoking, and arterial hypertension (HT).…”

“…There is no doubt that the mechanisms of ED development in comorbid pathology are complicated and insufficiently studied [1]. Of particular interest is the study of comorbid conditions, each of which is characterized by the presence of ED in the pathogenesis and factors that exacerbate it, which may manifest itself in the enhancement of VEGF-A expression and obviously play an important role in understanding the commonality of pathogenetic processes and developing more effective preventive and therapeutic measures.…”