Functional Connectivity Analysis with Voxel-Based Morphometry for Diagnosis of Mild Cognitive Impairment

Kim, JungHoe; Lee, Jong‐Hwan

doi:10.1007/978-3-642-24955-6_37

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Given these considerations, the approach of measuring mean cortical thickness to reflect neurodegeneration can also be viewed critically, since the impact of cortical atrophy on FC may vary for different regions. Age-dependent cortical atrophy has been observed in several studies (Fjell et al, 2009;Azevedo et al, 2019) and could already be linked to FC (Kim and Lee, 2011;Van Tol et al, 2014). Cortical thickness has also been associated with white matter lesions (Mayer et al, 2020) and conceptualized as mechanism underlying this association, secondary cortical degeneration through white matter tracts damaged by WMH (Thong et al, 2013) was suggested.…”

Section: Variablesmentioning

confidence: 99%

Association of Age and Structural Brain Changes With Functional Connectivity and Executive Function in a Middle-Aged to Older Population-Based Cohort

Schulz

Mayer

Schlemm

et al. 2022

Front. Aging Neurosci.

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Aging is accompanied by structural brain changes that are thought to underlie cognitive decline and dementia. Yet little is known regarding the association between increasing age, structural brain damage, and alterations of functional brain connectivity. The aim of this study was to evaluate whether cortical thickness and white matter damage as markers of age-related structural brain changes are associated with alterations in functional connectivity in non-demented healthy middle-aged to older adults. Therefore, we reconstructed functional connectomes from resting-state functional magnetic resonance imaging (MRI) (rsfMRI) data of 976 subjects from the Hamburg City Health Study, a prospective population-based study including participants aged 45–74 years from the metropolitan region Hamburg, Germany. We performed multiple linear regressions to examine the association of age, cortical thickness, and white matter damage quantified by the peak width of skeletonized mean diffusivity (PSMD) from diffusion tensor imaging on whole-brain network connectivity and four predefined resting state networks (default mode, dorsal, salience, and control network). In a second step, we extracted subnetworks with age-related decreased functional connectivity from these networks and conducted a mediation analysis to test whether the effect of age on these networks is mediated by decreased cortical thickness or PSMD. We observed an independent association of higher age with decreased functional connectivity, while there was no significant association of functional connectivity with cortical thickness or PSMD. Mediation analysis identified cortical thickness as a partial mediator between age and default subnetwork connectivity and functional connectivity within the default subnetwork as a partial mediator between age and executive cognitive function. These results indicate that, on a global scale, functional connectivity is not determined by structural damage in healthy middle-aged to older adults. There is a weak association of higher age with decreased functional connectivity which, for specific subnetworks, appears to be mediated by cortical thickness.

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