Functional connectivity disruption of the substantia nigra associated with cognitive impairment in acute mild traumatic brain injury

Lu, Liangliang; Li, Fengfang; Ma, Yuehong; Chen, Huiyou; Wang, Peng; Peng, Mingyang; Chen, Yu‐Chen; Yin, Xindao

doi:10.1016/j.ejrad.2019.03.002

Cited by 12 publications

(18 citation statements)

References 27 publications

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“…and disrupted functional connectivity of a.i. with other brain regions in mTBI patients during the acute stage (Li et al 2019;Lu et al 2019). All these results indicated the vital role of a.i.…”

Section: Introductionmentioning

confidence: 63%

“…We have previously observed that the functional connectivity of a.i. with other brain regions is impaired in mTBI patients during the acute stage (Li et al 2019;Lu et al 2019). However, the connectivity patterns of insula subdivisions to other brain regions within mTBI patients as compared to healthy controls have not been further studied.…”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence consistently highlighted that a.i. is in response for cognitive function (Taylor et al 2009;Chand et al 2017;Peng et al 2018;Lu et al 2019). Additionally, we have previously shown decreased grey matter volumes of a.i.…”

Section: Introductionmentioning

confidence: 87%

“…However, growing findings showed that the insula plays a crucial role in response for salience events and mediates the control of cognition (Uddin et al 2014). Our previous work observed that the gray matter volume was significantly reduced in the insula in acute mTBI patients and the functional connectivity of insula with other brain regions was impaired in mTBI patients during the acute stage (Li et al 2019;Lu et al 2019). Following mTBI, previous neuroimaging studies have shown structural and functional connectivity abnormalities in the insula, such as smaller volume, decreased regional homogeneity (ReHo) and cerebral blood flow (CBF), and these alterations were related to cognitive scores.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, parcellation studies using resting state fMRI (rs-fMRI) data revealed that the human insula can be subdivided into the anterior insula (a.i.) and the posterior insula (PI) which are involved in a wide range of cognitive processes, especially in restoring the cognitive functions (Iaria et al 2008;Taylor et al 2009;Lu et al 2019). Recent evidence consistently highlighted that a.i.…”

Section: Introductionmentioning

confidence: 99%

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Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Chen

et al. 2020

Brain Imaging and Behavior

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Purpose This study aimed to investigate the early functional connectivity alterations between insula subdivisions and other cortical regions in patients with acute mild traumatic brain injury (mTBI) and subsequently to explore the relationship between functional connectivity changes of insula subdivisions with other cortical regions and cognitive function. Methods Fifty-three mTBI patients and 37 age-, gender-and education level-matched healthy controls were included in this study. All participants obtained resting state functional magnetic resonance imaging (rs-fMRI) and clinical and neuropsychological evaluations (Montreal cognitive assessment, MoCA) at the acute stage. Functional connectivity alterations of insula subdivisions and correlations with MoCA were further explored by seed-voxel functional connectivity. Results Compared with healthy controls, patients with acute mTBI showed significantly decreased functional connectivity between the L-vAI and the left middle temporal gyrus and right superior frontal gyrus and significantly decreased functional connectivity between the R-vAI and the right middle frontal gyrus and right hippocampus. While significantly decreased functional connectivity were observed between the L-dAI and the right superior frontal gyrus. In addition, significantly increased functional connectivity was observed between the R-PI and the left inferior frontal gyrus. Furthermore, the mTBI group demonstrated positive correlations between performances in orientation and insula and middle temporal gyrus and superior frontal gyrus and middle frontal gyrus functional connectivities. Abstraction scores for mTBI patients positively correlated with functional connectivity between insula and middle frontal gyrus. Conclusions The present study demonstrated functional connectivity dysfunction of insula subdivisions and correlations between these alterations and cognitive performance, which provide a novel insight into the neurophysiological mechanism of cognitive impairment in patients with mTBI at the acute stage.

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Section: Introductionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Chen

et al. 2020

Brain Imaging and Behavior

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Atypical resting state functional connectivity in mild traumatic brain injury

et al. 2021

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Objectives: This study aimed to investigate changes in three intrinsic functional connectivity networks (IFCNs; default mode network [DMN], salience network [SN], and task-positive network [TPN]) in individuals who had sustained a mild traumatic brain injury (mTBI).Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 27 mTBI patients with persistent postconcussive symptoms, along with 26 age-and sex-matched controls. These individuals were recruited from a Level-1 trauma center, at least 3 months after a traumatic episode. IFCNs were established based on seed-to-voxel, region-of-interest (ROI) to ROI, and independent component analyses (ICA). Subsequently, we analyzed the relationship between functional connectivity and postconcussive symptoms.Results: Seed-to-voxel analysis of rs-fMRI demonstrated decreased functional connectivity in the right lateral parietal lobe, part of the DMN, and increased functional connectivity in the supramarginal gyrus, part of the SN. Our TPN showed both hypoand hyperconnectivity dependent on seed location. Within network hypoconnectivity was observed in the visual network also using group comparison. Using an ICA, we identified altered network functional connectivity in regions within four IFCNs (sensorimotor, visual, DMN, and dorsal attentional). A significant negative correlation between dorsal attentional network connectivity and behavioral symptoms score was also found. Conclusions:Our findings indicate that rs-fMRI may be of use clinically in order to assess disrupted functional connectivity among IFCNs in mTBI patients. Improved mTBI diagnostic and prognostic information could be especially relevant for athletes looking to safely return to play, as well for individuals from the general population with persistent postconcussive symptoms months after injury, who hope to resume activity.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

Lunkova

Guberman

Ptito

et al. 2021

Human Brain Mapping

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Mild traumatic brain injury (mTBI), frequently referred to as concussion, is one of the most common neurological disorders. The underlying neural mechanisms of functional disturbances in the brains of concussed individuals remain elusive. Novel forms of brain imaging have been developed to assess patients postconcussion, including functional magnetic resonance imaging (fMRI), susceptibility‐weighted imaging (SWI), diffusion MRI (dMRI), and perfusion MRI [arterial spin labeling (ASL)], but results have been mixed with a more common utilization in the research environment and a slower integration into the clinical setting. In this review, the benefits and drawbacks of the methods are described: fMRI is an effective method in the diagnosis of concussion but it is expensive and time‐consuming making it difficult for regular use in everyday practice; SWI allows detection of microhemorrhages in acute and chronic phases of concussion; dMRI is primarily used for the detection of white matter abnormalities, especially axonal injury, specific for mTBI; and ASL is an alternative to the BOLD method with its ability to track cerebral blood flow alterations. Thus, the absence of a universal diagnostic neuroimaging method suggests a need for the adoption of a multimodal approach to the neuroimaging of mTBI. Taken together, these methods, with their underlying functional and structural features, can contribute from different angles to a deeper understanding of mTBI mechanisms such that a comprehensive diagnosis of mTBI becomes feasible for the clinician.

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Functional connectivity disruption of the substantia nigra associated with cognitive impairment in acute mild traumatic brain injury

Cited by 12 publications

References 27 publications

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury

Atypical resting state functional connectivity in mild traumatic brain injury

Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

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