2013
DOI: 10.1016/j.pain.2013.05.001
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Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn

Abstract: SummaryNeurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the spinal cord differ in their receptor expression pattern and responses to noxious stimuli.

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Cited by 86 publications
(103 citation statements)
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“…For example, Polgar et al recently reported that mechanical, thermal and chemical noxious inputs activate a large number of GAL and NPY-expressing neurons (monitored by phosphorylation of extracellular signal-regulated kinase (ERK), but very few nNOS-expressing inhibitory interneurons (Polgar et al, 2013). Furthermore, there is evidence that the sst2A somatostatin receptor is expressed by virtually all GAL-positive and nNOS-positive neurons, but few NPY-expressing and none of the PV-positive neurons.…”
Section: Introductionmentioning
confidence: 99%
“…For example, Polgar et al recently reported that mechanical, thermal and chemical noxious inputs activate a large number of GAL and NPY-expressing neurons (monitored by phosphorylation of extracellular signal-regulated kinase (ERK), but very few nNOS-expressing inhibitory interneurons (Polgar et al, 2013). Furthermore, there is evidence that the sst2A somatostatin receptor is expressed by virtually all GAL-positive and nNOS-positive neurons, but few NPY-expressing and none of the PV-positive neurons.…”
Section: Introductionmentioning
confidence: 99%
“…Both class B excitatory and inhibitory neurons can be further subdivided into molecularly distinct subtypes marked by the expression of peptides, transmitter receptors, and signaling molecules (summarized in Fig. 4a) 4349 . Developmentally, Tlx3 acts as a selective gene that is required to specify most known features associated with class B excitatory neurons, including glutamatergic and peptidergic transmitters 42, 44, 45 .…”
Section: Developmental Ontogeny Of Spinal Neuronsmentioning
confidence: 99%
“…inhibitory interneurons which play important roles in processing nociception from peripheral to the central structures [9]. Several lines of evidence show that diverse interneurons have specific morphological and physiological features [12], and interneurons in the dorsal horn superficial laminae (I-III) play distinct roles [9,20,22]. However, it was impossible to causally implicate the contribution of specific neurons.…”
Section: Introductionmentioning
confidence: 99%
“…Finally, we examined the modulation of GABA release by presynaptic GABA B receptor activation. Because lamina II of the dorsal horn, which is also known as the substantia gelatinosa (SG), mainly consists heterogeneous populations of cells, including PV interneurons [1,9,14,20], our present data were predominantly collected from neurons within the SG.…”
Section: Introductionmentioning
confidence: 99%