Functional Disintegration of the Default Mode Network in Prodromal Alzheimer’s Disease

Dillen, Kim; Jacobs, Heidi I.L.; Kukolja, Juraj; Richter, Nils; Reutern, Boris von; Onur, Oezguer A.; Langen, Karl‐Josef; Fink, Gereon R.

doi:10.3233/jad-161120

Cited by 91 publications

(88 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disruption of functional coupling between the anterior and posterior parts of the DMN has been previously described in AD [39, 40] and might be explained by an alteration of anatomical connections between these regions [39]. The second result is con sistent with the findings of Agosta et al [18], showing a decreased mean functional connectivity in the LFPN in AD patients compared to controls, and tends to highlight a similar pattern of functional connectivity loss in AD and DLB.…”

Section: Discussionmentioning

confidence: 99%

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Chabran

Roquet

Gounot

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Aims: Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB patients compared with Alzheimer disease (AD) patients and healthy elderly control subjects. Methods: Twenty-six DLB, 29 AD, and 22 healthy subjects underwent a detailed clinical and neuropsychological examination along with a functional MRI during the different conditions of a visuoperceptual paradigm. Functional images were analyzed using group-level spatial independent component analysis and seed-based connectivity analyses. Results: While the DLB patients scored well and did not differ from the control and AD groups in terms of functional activity and connectivity during the task conditions, they showed decreased functional connectivity in visuoperceptual regions during the resting state condition, along with a temporal impairment of the default-mode network activity. Functional connectivity disturbances were also found within two attentional-executive networks and between these networks and visuoperceptual regions. Conclusion: We found a specific functional profile in the switching between task and resting state conditions in DLB patients. This result could help better characterize functional impairments in DLB and their contribution to several core symptoms of this pathology such as visual hallucinations and cognitive fluctuations.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Chabran

Roquet

Gounot

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…The DMN is a major resting state network affected by AD and a site where Aβ deposition, hypometabolism and regional atrophy converge (Buckner, et al, 2008). In particular, reduced efficacy in long-distance functional connections between anterior and posterior parts of the DMN is a prominent feature of AD (Badhwar, et al, 2017; Dillen, et al, 2017; Sanz-Arigita, et al, 2010). The “network degeneration hypothesis” suggests that AD-related pathology initiates in and propagates along specific neuronal populations that follow the trajectory of intrinsic structural or functional brain networks (Palop, et al, 2006; Seeley, et al, 2009; Tahmasian, et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Decoupling of inter-regional functional connectivity and regional neural activity in Alzheimer Disease

Maleki-Balajoo

Rahmani²,

Khosrowabadi

et al. 2019

Preprint

View full text Add to dashboard Cite

199/200)Alzheimer's disease (AD) and mild cognitive impairment (MCI) are characterized by aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). It is, however, poorly understood how changes in regional neural activity and inter-regional FC interact in AD and MCI. Here, we investigated the link between regional neural activity and nodal topological measures of FC through simultaneous PET/MR measurement in 20 patients with MCI, 33 patients with AD, and 26 healthy individuals. First, we assessed regional glucose metabolism identified through FDG-PET (rFDG) (as a proxy of regional neural activity), and regional FC topology through clustering coefficient (CC) and degree centrality (DC) (as surrogates of local segregation and global connectivity, respectively). Next, we examined the potential moderating effect of disease status (AD or MCI) on the link between rFDG and FC topology using hierarchical moderated multiple regression analysis. Alterations in rFDG, CC, and DC were widespread in patients, and AD alters physiological coupling between regional metabolism and functional connectivity particularly in the inferior temporal gyus and supplementary motor areas. While rFDG correlated with CC in healthy subjects, this correlation was lost in AD patients. We suggest that AD pathology decouples the normal association between regional neural activity and functional segregation.

show abstract

“…Electroencephalography, on the other hand, is a promising tool to assess the AD-related functional disintegration of large scale brain networks such as the default mode network during resting state (Dillen et al, 2017;Horn, Ostwald, Reisert, & Blankenburg, 2014).…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging markers of global cognition in early Alzheimer's disease: A magnetic resonance imaging–electroencephalography study

et al. 2018

View full text Add to dashboard Cite

IntroductionMagnetic resonance imaging (MRI) and electroencephalography (EEG) are a promising means to an objectified assessment of cognitive impairment in Alzheimer's disease (AD). Individually, however, these modalities tend to lack precision in both AD diagnosis and AD staging. A joint MRI–EEG approach that combines structural with functional information has the potential to overcome these limitations.Materials and MethodsThis cross‐sectional study systematically investigated the link between MRI and EEG markers and the global cognitive status in early AD. We hypothesized that the joint modalities would identify cognitive deficits with higher accuracy than the individual modalities. In a cohort of 111 AD patients, we combined MRI measures of cortical thickness and regional brain volume with EEG measures of rhythmic activity, information processing and functional coupling in a generalized multiple regression model. Machine learning classification was used to evaluate the markers’ utility in accurately separating the subjects according to their cognitive score.ResultsWe found that joint measures of temporal volume, cortical thickness, and EEG slowing were well associated with the cognitive status and explained 38.2% of ifs variation. The inclusion of the covariates age, sex, and education considerably improved the model. The joint markers separated the subjects with an accuracy of 84.7%, which was considerably higher than by using individual modalities.ConclusionsThese results suggest that including joint MRI–EEG markers may be beneficial in the diagnostic workup, thus allowing for adequate treatment. Further studies in larger populations, with a longitudinal design and validated against functional‐metabolic imaging are warranted to confirm the results.

show abstract

Functional Disintegration of the Default Mode Network in Prodromal Alzheimer’s Disease

Cited by 91 publications

References 116 publications

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Decoupling of inter-regional functional connectivity and regional neural activity in Alzheimer Disease

Neuroimaging markers of global cognition in early Alzheimer's disease: A magnetic resonance imaging–electroencephalography study

Contact Info

Product

Resources

About