Functional disorders of motor activity of the digestive tract and their osteopathic correction in patients with celiac disease

Оrеshkо, A. Yu.; Орешко, Л. С.; Селиверстов, П. В.; Семенова, Е. А.; Мохов, Д. Е.; Трегубова, Е. С.

doi:10.31146/1682-8658-ecg-162-2-36-44

Cited by 3 publications

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“…Мотилин расширяет сосуды желудка, способствует запуску желудочных мигрирующих моторных комплексов, регулирует моторику желудочно-кишечного тракта в перерывах между приемами пищи [21,22]. Он является полипептидом, содержащим 22 аминокислоты [23], и секретируется в период голодания энтерохромафинными клетками, расположенными в толще слизистой антрального отдела желудка, двенадцатиперстной, тощей и сигмовидной кишок [24,25]. Изменения в количественном и качественном составе секретирующих мотилин клеток в слизистой оболочке желудочно-кишечного тракта коррелируют с клинической симптоматикой при функциональной гастроинтестинальной патологии [26].…”

Section: резюмеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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Purpose of the study: to clarify the effect of the concentration of motilin in the blood on the clinical symptoms of functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22,3±0,17 years was carried out, divided into 3 groups: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. All subjects were questioned according to the GSRS questionnaire, and the concentration of motilin in their blood was determined before and after the drinking test. Statistical processing included the calculation of mean values, their errors, Student’s t-test, Pearson’s correlation test, factor analysis. Results. In patients with PDS, the intensity of abdominal pain (2,47±0,38 points) does not differ from healthy ones (2,19±0,22 points), in patients with EPS it is higher (4,33±0,51 points). Dyspeptic syndrome is more typical for patients with PDS (2,07±0,12 points) than for EPS (1,10±0,04 points). The concentration of motilin in the blood on an empty stomach with PDS (9605,47±167,64 pg/ml) is higher than with EPS (8780,67±232,27 pg/ml). After the drinking test, the level of motilin in the blood of patients with EPS increased to 9367,33±145,78 pg/ml, the PDS decreased to 9323,33±239,04 pg/ml. With PDS, the severity of reflux syndrome directly correlates with the concentration of motilin in the blood. In EPS, the initial level of motilin correlates inversely with the severity of reflux syndrome, constipation syndrome, and the volume of water drunk. After the drinking test, there is an inverse correlation between the level of motilin and the severity of diarrheal and dyspeptic syndromes, and a direct correlation with the intensity of abdominal pain. The initial level of motilin in the blood brings the greatest factor load into the “factor of motor disorders”. Conclusion. The initial level of motilin and its dynamics during water load play an essential role in the formation of the clinical picture of functional dyspepsia.

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Section: резюмеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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“…В последние годы в терапевтической гастроэнтерологии находит применение метод оценки моторики верхних отделов органов пищеварения с помощью периферической электрогастроэнтерографии (ПЭГЭГ), основанный на регистрации электрической активности желудка, двенадцатиперстной кишки и кишечника. Метод позволяет оценить двигательную активность (общий тонус, ритмичность, мощность, координацию сокращений) в две фазы (натощак и после пищевой стимуляции) [12]. При этом полученная электрогастроэнтерограмма дает представление о электрофизиологической активности исследуемых отделов ЖКТ, но не передает информацию об объемах желудочного содержимого.…”

Section: Introductionunclassified

Magnetic resonance imaging with a stress drinking test as a method of assessing the evacuation function of the stomach

Shklyaev

Максимов

Panteleev

2023

jour

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Aim: to study opportunity of research the evacuation function of the stomach in young people by magnetic resonance imaging with a stress drinking test. Materials and methods: the study group included 20 young people (10 men and 10 women aged 23 ± 1,12 years). At the time of the study, each test person excluded organic and functional pathologies of the gastroduodenal zone. A method of magnetic resonance imaging of the stomach with a stress drinking test (still drinking water at room temperature with a volume of 1000.0 ml) was used. The examination lasted 30 minutes, scanning was carried out every 5 minutes, a total of 7 scans. Based on the obtained three-dimensional images of the DICOM format using the HorosMobile™ application (DICOM medical image viewer), the volumes of fluid in the stomach in dynamics were calculated for each test person in the study group according to the time intervals of the scans performed by the magnetic resonance imaging machine. Systematization and data processing were carried out a Microsoft Excel. A single graph was built for the study group in the Pages graphical editor (iWork productivity suite) based on the obtained data, reflecting the reference volumes of gastric contents relative to the time scale with possible deviations from the average. Results: regardless of the type of physique and shape of the stomach in the studied subjects, the evacuation of a larger volume of fluid (81,53-82,54%) occurred by the 15th minute of the study. Complete evacuation of gastric contents occurs between 25 and 30 minutes of the study. Conclusions: the results obtained by MRI studies of the stomach with a stress drinking test give an idea of the options for normal physiological evacuation of gastric contents in young people, in the absence of organic and functional pathology of the gastroduodenal zone.

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Evaluation of the clinical effectiveness of osteopathic gallbladder drainage techniques

Belash,

Zavadsky,

Zueva

2024

Rossijskij osteopaticheskij zhurnal

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Introduction. In recent decades, a lot of new materials about etiology and pathogenesis of biliary system diseases have been obtained and new effective drugs have been introduced. But, despite this, there remains much unrecognized and controversial in etiopathogenesis and principles of treatment of the disease. Moreover, the frequency of complicated forms of the disease and the overall incidence of biliary pathology continues to grow, which clearly shows the need to search for new approaches to diagnosis and treatment of these conditions. The leading causes of biliary tract pathology formation, actual problems of pharmacotherapy (allergic reactions, side effects, polypragmasy), certain aspects of comorbid pathology make clinicians pay closer attention to non-medicament treatment methods, including osteopathic correction. Previous studies have already demonstrated a good clinical effect of osteopathic correction in the treatment of patients with biliary disorders. At the same time, most studies in osteopathy present an assessment of the possibility of using osteopathic correction in the treatment of certain nosological forms. But no less important, in our opinion, is to conduct studies aimed at evaluating the clinical effectiveness (efficiency) of individual osteopathic approaches and techniques.The aim of the study: to investigate the clinical effectiveness of osteopathic techniques of gallbladder drainage.Materials and methods. The study was conducted in 2022–2023 on the basis of Polyclinic of the Federation of Independent Trade Unions of Russia (Moscow) and City Mariinsky Hospital (St. Petersburg). There were 30 people (9 men and 21 women) aged 18 to 59 years (mean age was 40,4±2,3 years) without pathology of the gastrointestinal tract and gallbladder (biliary tract) who agreed to participate in the study. All participants underwent a fasting gallbladder volume study, followed by a gallbladder volume study one hour after eating a trial breakfast (TB). One week after the first study, the same patients underwent another fasting gallbladder volume study, then a gallbladder volume study after osteopathic correction (OC) techniques. Thus two observation groups were formed: observation 1 (TB) — study of gallbladder function before and after taking a trial breakfast; observation 2 (OC) — study of gallbladder function before and after gallbladder drainage techniques. Participants did not receive other treatments during the study. All respondents underwent clinical osteopathic examination and biliary ultrasound with motor function score (MFS) was performed. Outcomes in this study were defined as changes in gallbladder size and motility.Results. No global level somatic dysfunction was identified in the study participants. Regional biomechanical disorders and separate local somatic dysfunctions were more typical for them. However, it was not possible to identify any predominant dysfunctions, as all of them were detected in single cases. After the exposure was completed, the osteopathic status was re-evaluated. The analysis showed that there were no statistically significant changes in the frequency of detection of the main somatic dysfunctions in both observations (p>0,05). In the observed respondents, no abnormalities in the basic size and volume of the gallbladder at the beginning of the study were revealed. After the conducted stimulation no statistically significant differences in gallbladder size (length and width) both within and between the observation groups were registered (p>0,05), but statistically significant dynamics was obtained in the form of gallbladder volume decrease in response to the effect (p<0,05) both when using TB and after OC. All participants were assessed with a measure of gallbladder motor function (MFS). In case of observation 1 (TB), the MFS value was 0,66±0,09 and observation 2 (OC) was 0,58±0,07, which corresponds to normal gallbladder functional activity. Compared to the use of a trial breakfast, osteopathic correction demonstrated a slightly less pronounced effect on gallbladder motor function, but these differences between the groups were not statistically significant (p>0,05).Conclusion. Osteopathic manipulations on the gallbladder and biliary tract have an effect on the gallbladder volume and motor activity comparable to the effect of the trial breakfast.

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Functional disorders of motor activity of the digestive tract and their osteopathic correction in patients with celiac disease

Cited by 3 publications

References 0 publications

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Magnetic resonance imaging with a stress drinking test as a method of assessing the evacuation function of the stomach

Evaluation of the clinical effectiveness of osteopathic gallbladder drainage techniques

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