Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities

D'Sa-Eipper, Cleta; Chinnadurai, G.

doi:10.1038/sj.onc.1201851

Cited by 68 publications

(57 citation statements)

References 32 publications

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“…37 Bfl-1 has also been shown to lack the anti-proliferative capacity that has been reported for bcl-2. 41 In B-CLL cells, the role of bfl-1 has not been well studied, but its mRNA was found to be upregulated, together with mcl-1 and bcl-2 by sIgM engagement, which promoted survival of leukemic cells. 42 Interestingly, within the rB-CLL group, although the number of patients in our study is small, we observed that patients with lower bfl-1 expression had high bcl-2 expression, so that bfl-1 and bcl-2 expression seem to be complementary to each other.…”

Section: Discussionmentioning

confidence: 99%

High expression of Bfl‐1 contributes to the apoptosis resistant phenotype in B‐cell chronic lymphocytic leukemia

Morales

Olsson

Celsing

et al. 2004

Intl Journal of Cancer

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In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and compared between 2 groups of B-CLL patients with either nonprogressive, indolent, previously untreated disease and with leukemic cells sensitive to in vitro fludarabine-induced apoptosis, referred to as sensitive B-CLL (sB-CLL) or with progressive, chemotherapy refractory disease and with leukemic cells resistant to in vitro fludarabine-induced apoptosis, referred to as resistant B-CLL (rB-CLL). By performing a supervised clustering of genes that most strongly discriminated between rB-CLL vs. sB-CLL a small group of genes was identified, where bfl-1 was the strongest discriminating gene (p < 0.05), with higher expression in rB-CLL. A group of apoptosis-regulating genes were modulated during induction of apoptosis by serum deprivation in vitro in a similar manner in all cases studied. However, bfl-1 was preferentially downregulated in sB-CLL as compared to rB-CLL (p < 0.05). We conclude that bfl-1 may be an important regulator of B-CLL apoptosis, which could contribute to disease progression and resistance to chemotherapy, and as such represent a future potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

High expression of Bfl‐1 contributes to the apoptosis resistant phenotype in B‐cell chronic lymphocytic leukemia

Morales

Olsson

Celsing

et al. 2004

Intl Journal of Cancer

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“…42 Figure 6 illustrates that the conditioned medium from the HS-MSCs clearly reduced the expression of Bfl-1 in the tumor cells. This result implies that tumor cell progression might be markedly weakened by the contents released from the HS-MSCs, and suggests that identification of these contents may provide novel candidates for targeted cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia‐treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line

Cho

Park

Kim

et al. 2009

Cancer

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“…A1 prevents cell death as a downstream effector of NF-κB signaling [26][27][28][29]. A1/Bfl-1 has been identified as a transcriptional target of pre-TCR signal.…”

Section: Anti-apoptotic Bh1-4 Subfamilymentioning

confidence: 99%

The role of apoptosis in the development and function of T lymphocytes

et al. 2005

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Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.

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Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities

Cited by 68 publications

References 32 publications

High expression of Bfl‐1 contributes to the apoptosis resistant phenotype in B‐cell chronic lymphocytic leukemia

High expression of Bfl‐1 contributes to the apoptosis resistant phenotype in B‐cell chronic lymphocytic leukemia

Hyperthermia‐treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line

The role of apoptosis in the development and function of T lymphocytes

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