2009
DOI: 10.1016/j.placenta.2009.03.009
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Functional Expression of the Human Neonatal Fc-receptor, hFcRn, in Isolated Cultured Human Syncytiotrophoblasts

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Cited by 18 publications
(7 citation statements)
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“…This pH-dependent hFcRn-Fc(IgG) interaction is responsible for transcytotic and protective functions of hFcRn. The human neonatal Fc receptor is a key protein involved in the transport of maternal IgG to the fetus, providing protective immunity to the newborn [ 17 ]. The second important role of hFcRn is the protection of IgG from catabolism and the maintenance of IgG and albumin homeostasis [ 18 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…This pH-dependent hFcRn-Fc(IgG) interaction is responsible for transcytotic and protective functions of hFcRn. The human neonatal Fc receptor is a key protein involved in the transport of maternal IgG to the fetus, providing protective immunity to the newborn [ 17 ]. The second important role of hFcRn is the protection of IgG from catabolism and the maintenance of IgG and albumin homeostasis [ 18 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Both hFcRn subunits have been co-localized in endosomes in villous STB in situ [17] and in STB in culture [18]. While hFcRn expression in the STB is generally accepted, contradictory data have been reported on the expression and potential function of hFcRn in fetal endothelial cells [19][20][21].…”
Section: Hfcrn Expression In Placental Terminal Villimentioning
confidence: 99%
“…On syncytiotrophoblasts and on placental endothelial cells the neonatal Fc receptor (FcRn) is expressed [82][83][84][85] and involved in the transfer of IgG. The immunoglobulins in the fetus consist almost totally of maternal IgG and are transferred across the placenta by means of a large number of different receptors.…”
Section: The Placenta -A Barrier?mentioning
confidence: 99%
“…The immunoglobulins in the fetus consist almost totally of maternal IgG and are transferred across the placenta by means of a large number of different receptors. The binding of IgG to the FcRn is pH-dependent: At pH of 6.0 there is high affinity for IgG; at neutral pH, as in maternal blood, the affinity of the FcRn is 100-fold lower for IgG [83,85]. On syncytiotrophoblasts and on placental endothelial cells the neonatal Fc receptor (FcRn) is expressed [82][83][84][85] and involved in the transfer of IgG.…”
Section: The Placenta -A Barrier?mentioning
confidence: 99%
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