Functional foods: promising therapeutics for Nigerian Children with sickle cell diseases

Alabi, Oladeji J.; Adegboyega, Fikayo Noah; Olawoyin, Dolapo S.; Babatunde, Oluwakemi Arinola

doi:10.1016/j.heliyon.2022.e09630

Cited by 5 publications

(14 citation statements)

References 115 publications

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“…The implications of apoptosis for SCA progression are multifaceted, contributing to the overall clinical picture and complications associated with the disease. [ 36 ] Apoptosis of sickle red blood cells leads to their premature destruction, a process known hemolysis. [ 37 ] This results in anemia, a hallmark of SCA, characterized by reduced oxygen-carrying capacity and symptoms such as fatigue, weakness, and pallor.…”

Section: Methodsmentioning

confidence: 99%

Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

Obeagu,

Ubosi,

Obeagu

et al. 2024

Medicine

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Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much research has focused on the molecular and cellular mechanisms underlying the pathophysiology of SCA, recent attention has turned to the role of apoptosis, or programmed cell death, in the disease progression. This review aims to elucidate the intricate mechanisms of apoptosis in SCA patients and explore its implications in disease severity, complications, and potential therapeutic interventions. Different research search engines such as PubMed central, Scopus, Web of Science, Google Scholar, ResearchGate, Academia Edu, etc were utilized in writing this paper. Apoptosis, a highly regulated cellular process, plays a crucial role in maintaining homeostasis by eliminating damaged or dysfunctional cells. In SCA, the imbalance between pro-apoptotic and anti-apoptotic signals contributes to increased erythrocyte apoptosis, exacerbating anemia and vaso-occlusive crises. Various factors, including oxidative stress, inflammation, and altered cell signaling pathways, converge to modulate the apoptotic response in SCA. Furthermore, the interaction between apoptotic cells and the vascular endothelium contributes to endothelial dysfunction, promoting the pathogenesis of vasculopathy and organ damage seen in SCA patients. In conclusion, unraveling the complexities of apoptosis in SCA provides valuable insights into the disease pathophysiology and offers novel avenues for therapeutic interventions.

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Section: Methodsmentioning

confidence: 99%

Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

Obeagu,

Ubosi,

Obeagu

et al. 2024

Medicine

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“…In addition, the phytochemicals in the ethanolic and aqueous extracts of F. virosa and K. africana, owing to their antioxidant potential, are thought to target vasocclusion by modulating inflammatory responses to stabilise sickle cell membranes in order to prevent haemolysis-mediated endothelial dysfunction [34] (Figure 5). A phytomedicine based on these compounds could protect the membranes of sickle cell patients by supplementing the enzymatic defence systems of deficient erythrocyte.…”

Section: In Vitro Evaluation Of the Antifalcemic Activitymentioning

confidence: 99%

Phytochemical Characterization and In Vitro Evaluation of the Anti-Sickle Cell Activity of Aqueous and Ethanolic Extracts of Two Medicinal Plants from Niger: Flueggea virosa (Roxb. ex Willd.) Royle and Kigelia africana (Lam.) Benth

Souleymane,

Djibo,

Seyni

et al. 2023

Plants

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Sickle cell anaemia is a hereditary blood disorder that attacks the red blood cells and deforms them, giving them a sickle shape. Sickle cell anaemia is a serious health problem in the West African country of Niger. Moreover, the cost associated with medical care is very high. The main objective of this study is to contribute to the valorisation of Flueggea virosa (Roxb. ex Willd.) Royle (aerial part), Kigelia africana (lam), and Benth (leaves) from Niger were used to treat sickle cell disease using aqueous and ethanolic extracts of phytochemical compounds. To achieve this objective, the evaluation of anti-sickle cell activity was carried out in vitro using the Emmel technique through the normalisation rate. The analyses showed that the aqueous and ethanolic extracts contained various classes of bioactive substances known for their valuable biological activities. The chemical composition rich in bioactive compounds led to very good results in biological assays. Thus, from a dose of 0.05 mg/mL, the ethanolic extracts of the two plants normalised up to 75% of the sickle cells. As the rate of normalisation was shown to be dose-dependent, at a dose of 10 mg/mL, the ethanolic extracts showed the best rates of sickle cell normalisation, with 95% for F. virosa and 93% for K. africana. Phytochemical screening was used to correlate the secondary metabolite and anti-sickle cell activities of the extracts from the two plants. These results may justify the use of these two species in traditional medicine for the treatment of sickle cell disease in Niger. The inclusion of these plants in phytomedicines could provide significant relief to people suffering from sickle cell disease.

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“…The change in amino acid properties (hydrophilic to hydrophobic) within the β-globin chain contributes to the reduced solubility of HbS [ 5 ]. Therefore, the abnormal hemoglobin exhibits insolubility and polymerization in response to factors such as decreased oxygen tension, physical trauma, dehydration, stress, acidosis, or exposure to cold temperatures.…”

Section: Introductionmentioning

confidence: 99%

“…SCD can manifest in various clinical features, including abnormal eye growth in the retina (proliferative retinopathy), tissue death due to blocked blood flow (vascular necrosis), prolonged painful erection (priapism), dilute urine (hyposthenuria), episodes of severely reduced red blood cell production (aplastic crises), kidney problems (nephropathy), and lung disease [ 5 ]. For individuals with SCD, episodes of severe pain caused by blocked blood vessels (vaso-occlusive crisis) are the most frequent reason for emergency department visits and hospital admissions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

Gonçalves,

Smaoui,

Brito

et al. 2024

CIMB

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Sickle cell anemia (SCA), the most common form of sickle cell disease (SCD), is a genetic blood disorder. Red blood cells break down prematurely, causing anemia and often blocking blood vessels, leading to chronic pain, organ damage, and increased infection risk. SCD arises from a single-nucleotide mutation in the β-globin gene, substituting glutamic acid with valine in the β-globin chain. This review examines treatments evaluated through randomized controlled trials for managing SCD, analyzes the potential of functional foods (dietary components with health benefits) as a complementary strategy, and explores the use of bioactive compounds as functional food ingredients. While randomized trials show promise for certain drugs, functional foods enriched with bioactive compounds also hold therapeutic potential. Further research is needed to confirm clinical efficacy, optimal dosages, and specific effects of these compounds on SCD, potentially offering a cost-effective and accessible approach to managing the disease.

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Functional foods: promising therapeutics for Nigerian Children with sickle cell diseases

Cited by 5 publications

References 115 publications

Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

Phytochemical Characterization and In Vitro Evaluation of the Anti-Sickle Cell Activity of Aqueous and Ethanolic Extracts of Two Medicinal Plants from Niger: Flueggea virosa (Roxb. ex Willd.) Royle and Kigelia africana (Lam.) Benth

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

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