Functional genetic variability at promoters of pro‐(IL‐18) and anti‐(IL‐10) inflammatory affects their mRNA expression and survival in prostate carcinoma patients: Five year follow‐up study

Abstract

Genetic variants of pro-inflammatory IL-18 which showed higher relative mRNA expressions have better survival. Genetic variants of anti-inflammatory IL-10 with higher relative mRNA expression showed decreased chances of survival.

Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

“…On the other hand, the anti-angiogenic property of IL-10 may inhibit microvasculature formation and tumor growth. Previous studies have found that serum level of IL-10 was significantly elevated in urologic cancer, and it was closely correlated with tumor progression and metastasis (Stearns et al 1999; Uwatoko et al 2002; Dwivedi et al 2015a, b), which suggested that IL-10 may play a vital role in the development of urologic cancer.…”

“…For IL - 10 −592C>A polymorphism, a total of 14 studies including 5899 urologic cancer patients and 6181 control subjects were investigated (Dluzniewski et al 2012; Dwivedi et al 2015a, b; Eder et al 2007; Faupel-Badger et al 2008; Liu et al 2010; VanCleave et al 2010; Wang et al 2009; Winchester et al 2015; Xu et al 2005; Zabaleta et al 2008; Basturk et al 2005; Cozar et al 2007; Chang et al 2016; Chen et al 2013). HWE test for the control group of each included studies demonstrated that only 1 study deviated from HWE (see Table 1).…”

“…A total of 13 studies with 4655 cancer cases and 6344 healthy controls were enrolled to evaluate the association between IL - 10 −819C>T polymorphism and urologic cancer risk (Dwivedi et al 2015a, b; Faupel-Badger et al 2008; Liu et al 2010; VanCleave et al 2010; Winchester et al 2015; Zabaleta et al 2008; Basturk et al 2005; Cozar et al 2007; Chang et al 2016; Chen et al 2013; Kesarwani et al 2009; Michaud et al 2006; Ahirwar et al 2009). HWE test for the control group of eligible studies revealed that 4 studies violated HWE (see Table 2).…”

Prospects of Molecular Biotechnology in Diagnostics: Step Towards Precision Medicine

“…The AP-1 transcription factor is a regulator of processes essential for normal growth and development as well as carcinogenesis. Similarly, pro-inflammatory and anti-inflammatory interleukin's genotypes and gene expression have established their role in survival of prostate cancer patients [3][4][5]. Thus molecular diagnostics is going to swing the whole paradigm of screening and treatment.…”

Analytic and Dynamic Secretory Profile of Patient-Derived Cytokine-lnduced Killer Cells

“…IL-10 exerts positive homeostatic effects by downmodulating global immune response, thus preventing tissue damage and chronic inflammation; however, many reports have shown that IL-10 impairs cytotoxic responses of immune cells against tumors (49). Accordingly, elevated IL-10 concentration in serum and cerebrospinal fluid has been linked to poor prognosis in different tumors (50)(51)(52)(53), and inhibition of IL-10-mediated signaling increases T cell infiltration and responses against mouse tumors (54). However, recent findings demonstrated that IL-10 in combination with oncolytic virotherapy can enhance pancreatic cancer rejection (55).…”