Functional hair follicle regeneration: an updated review

Ji, Shuaifei; Zhu, Ziying; Sun, Xiaoyan; Fu, Xiaobing

doi:10.1038/s41392-020-00441-y

Cited by 130 publications

(93 citation statements)

References 148 publications

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“…Hence, the activation and stability of the hair regeneration cycle are key factors in achieving an intact HF. However, HF loss is often accompanied by the termination and/or dysregulation of the hair regeneration cycle, such as a shortened anagen phase or a failed transition from the telogen to anagen phase ( Ji et al, 2021). The activity of HFSCs and DPCs is the main driving force for the continuous hair regeneration cycle and is regulated by various signaling molecules (Rahmani et al, 2014;Chen et al, 2020a).…”

Section: Discussionmentioning

confidence: 99%

“…During hair regeneration, HFSCs proliferate and differentiate into HF components, and DPCs, which are now considered a reservoir of multipotent stem cells, regulate HF development and growth (Rahmani et al, 2014;Ji et al, 2021). HFSCs and DPCs undergo rapid proliferation to fuel the initial stage of hair growth that supports the prolonged growth of the hair (Rahmani et al, 2014;Ji et al, 2021). Based on the inhibited hair regeneration observed in the Fpr2 KO mice, we examined the activation of HFSCs and DPCs by assessing the specific activation markers for each cell type.…”

Section: Deletion Of Fpr2 Decreases Activation Of Hair Follicle Stem Cells (Hfscs) and Dermal Papilla Cells (Dpcs)mentioning

confidence: 99%

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Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice

Han¹,

Lee²,

Jung³

2021

Dev. Reprod.

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Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

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Section: Discussionmentioning

confidence: 99%

Section: Deletion Of Fpr2 Decreases Activation Of Hair Follicle Stem Cells (Hfscs) and Dermal Papilla Cells (Dpcs)mentioning

confidence: 99%

Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice

Han¹,

Lee²,

Jung³

2021

Dev. Reprod.

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“…Hair loss is a significant concern of human disorder regardless of age and gender. This can be attributed to aging, environmental reasons, stress, or the lack of hair follicle recovery due to poor tissue regeneration of injured tissues ( 88 ). Hair follicle is an ectodermal organ composed of two main parts, including the epithelium of keratinocytes and the mesenchyme of dermal papilla (DP) cells ( 89 ).…”

Section: Hair Follicle Regenerationmentioning

confidence: 99%

Biomaterials-assisted spheroid engineering for regenerative therapy

Lee

Bayaraa

Zechu

et al. 2021

BMB Rep

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Cell-based therapy is a promising approach in the field of regenerative medicine. As cells are formed into spheroids, their survival, functions, and engraftment in the transplanted site are significantly improved compared to single cell transplantation. To improve the therapeutic effect of cell spheroids even further, various biomaterials (e.g., nano- or microparticles, fibers, and hydrogels) have been developed for spheroid engineering. These biomaterials not only can control the overall spheroid formation (e.g., size, shape, aggregation speed, and degree of compaction), but also can regulate cell-to-cell and cell-to-matrix interactions in spheroids. Therefore, cell spheroids in synergy with biomaterials have recently emerged for cell-based regenerative therapy. Biomaterials-assisted spheroid engineering has been extensively studied for regeneration of bone or/and cartilage defects, critical limb ischemia, and myocardial infarction. Furthermore, it has been expanded to pancreas islets and hair follicle transplantation. This paper comprehensively reviews biomaterials-assisted spheroid engineering for regenerative therapy.

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“…All hair follicles periodically undergo a hair cycle that consists of anagen (growth), catagen (regression) and telogen (rest) ( Ji et al, 2021 ). Many recent studies have reported that hair cycle is regulated by the interaction between mesenchymal cells and epithelial cells in hair follicles, and the proliferation of dermal papilla (DP) cells by the activation of PI3K/Akt/Wnt/β-catenin pathway may be the key factor ( Botchkarev and Kishimoto, 2003 ; Kang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Kim

Jang

Kim

et al. 2022

Front. Cell Dev. Biol.

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Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss.

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Functional hair follicle regeneration: an updated review

Cited by 130 publications

References 148 publications

Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice

Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice

Biomaterials-assisted spheroid engineering for regenerative therapy

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

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