Functional Imaging of Hypoxia: PET and MRI

Perez, Ryan C.; Kim, Dae–Hee; Maxwell, Aaron W.P.; Camacho, Juan C.

doi:10.3390/cancers15133336

Cited by 6 publications

(3 citation statements)

References 208 publications

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“…Contrast-enhanced ultrasonography has demonstrated promise in its utilization for the prediction and assessment of liver tumor response after therapy [ 39 ]. Additionally, there are rapidly emerging techniques that utilize the injected microbubbles as either a carrier or therapeutic agent capable of facilitating the treatment and/or radio sensitization of tumors [ 40 ].…”

Section: Methods To Measure Hypoxiamentioning

confidence: 99%

“…Specifically, hydrophilic small molecule contrast agents like Gd-DTPA have been shown to diffuse past blood vessel walls and distribute within a tumor’s extracellular space as a function of blood perfusion, vascular density, tissue permeability, and extracellular volume fraction [ 48 ]. In other words, tumor Gd-DTPA T1 enhancement, including for liver tumors, is indirectly associated with increased tumor tissue oxygenation and can be used as a prognostic/assessment tool for treatment [ 40 , 49 ].…”

Section: Methods To Measure Hypoxiamentioning

confidence: 99%

“…Utilizes systemically injected microbubbles to assess perfusion within a tissue, which can then be correlated with tissue hypoxia. [19,[38][39][40]…”

Section: Physiologic Hypoxia Measurementmentioning

confidence: 99%

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Impact of Hypoxia on Radiation-Based Therapies for Liver Cancer

Villalobos,

Lee,

Westergaard

et al. 2024

Cancers

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Background: Hypoxia, a state of low oxygen level within a tissue, is often present in primary and secondary liver tumors. At the molecular level, the tumor cells’ response to hypoxic stress induces proteomic and genomic changes which are largely regulated by proteins called hypoxia-induced factors (HIF). These proteins have been found to drive tumor progression and cause resistance to drug- and radiation-based therapies, ultimately contributing to a tumor’s poor prognosis. Several imaging modalities have been developed to visualize tissue hypoxia, providing insight into a tumor’s microbiology. Methods: A systematic literature search was conducted in PubMed, EMBASE, Cochrane, and Google Scholar for all reports related to hypoxia on liver tumors. All relevant studies were summarized. Results: This review will focus on the impact of hypoxia on liver tumors and review PET-, MRI-, and SPECT-based imaging modalities that have been developed to predict and assess a tumor’s response to radiation therapy, with a focus on liver cancers. Conclusion: While there are numerous studies that have evaluated the impact of hypoxia on tumor outcomes, there remains a relative paucity of data evaluating and quantifying hypoxia within the liver. Novel and developing non-invasive imaging techniques able to provide functional and physiological information on tumor hypoxia within the liver may be able to assist in the treatment planning of primary and metastatic liver lesions.

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Section: Methods To Measure Hypoxiamentioning

confidence: 99%