Tumor microenvironment responsive nanozymes for multimodal imaging of tumors

Charged Gold Nanoparticles for Target Identification–Alignment and Automatic Segmentation of CT Image-Guided Adaptive Radiotherapy in Small Hepatocellular Carcinoma

“…This suggests that gold nanoparticles are well suited for targeted enhanced CT imaging in HCC because of their strong X-ray absorption and excellent biocompatibility. , Additionally, tumor microenvironment-responsive nanozyme technology facilitates nanoprobe creation that activates under specific tumor conditions, such as acidity and high hydrogen peroxide concentration. This induces tumor-specific catalytic reactions elevating or delaying imaging signals. − Leveraging the unique properties of nanozyme technology, the superb X-ray imaging performance of gold nanoparticles, and the acidic tumor microenvironment, our enzyme-modified charged Au NPs significantly extended the adequate imaging time up to 120 h compared with <24 h for the Au NP group. In a previous study, Li et al employed a similar approach to the one described above.…”