Functional Impact of<i>ZEB1</i>Mutations Associated With Posterior Polymorphous and Fuchs' Endothelial Corneal Dystrophies

Chung, Duk-Won D.; Frausto, Ricardo F.; Ann, Lydia; Jang, Michelle; Aldave, Anthony J.

doi:10.1167/iovs.14-15247

Cited by 32 publications

(34 citation statements)

References 40 publications

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“…The first reports of Phytomonas infections of plants initially described the host plants as exhibiting poor growth and wilt [ 9 ]. Subsequent observations in Euphorbia segetalis and Euphorbia peplus agreed that infection with Phytomonas was deleterious to the plant [ 11 ], and reported that infected plants exhibited a depletion of starch granules from the latex and surrounding parenchyma and a reduction in the viscosity of the latex [ 12 ]. However, in contrast to this, other authors stated that infections in different Euphorbiaceae produced no detectable effects on plant growth or yield.…”

Section: Phytomonas : Endophytes and Pathogensmentioning

confidence: 99%

Phytomonas: Trypanosomatids Adapted to Plant Environments

et al. 2015

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Over 100 years after trypanosomatids were first discovered in plant tissues, Phytomonas parasites have now been isolated across the globe from members of 24 different plant families. Most identified species have not been associated with any plant pathology and to date only two species are definitively known to cause plant disease. These diseases (wilt of palm and coffee phloem necrosis) are problematic in areas of South America where they threaten the economies of developing countries. In contrast to their mammalian infective relatives, our knowledge of the biology of Phytomonas parasites and how they interact with their plant hosts is limited. This review draws together a century of research into plant trypanosomatids, from the first isolations and experimental infections to the recent publication of the first Phytomonas genomes. The availability of genomic data for these plant parasites opens a new avenue for comparative investigations into trypanosomatid biology and provides fresh insight into how this important group of parasites have adapted to survive in a spectrum of hosts from crocodiles to coconuts.

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Section: Phytomonas : Endophytes and Pathogensmentioning

confidence: 99%

Phytomonas: Trypanosomatids Adapted to Plant Environments

et al. 2015

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“…FECD is a complex multifactorial inheritance disease with a variable expression rate and incomplete penetrance [41]. FECD-related genes include TCF4, COL8A2, ZEB1, AGBL1, SLC4A11, DMPK, LOXHD1, LAMC1, ATP1B1, and KANK4 [42][43][44], and environmental factors (especially UVA) also play an important role [45]. Due to its function and anatomical location, the corneal endothelial layer suffers from UVA exposure every day.…”

Section: Fuchs' Endothelial Corneal Dystrophy (Fecd)mentioning

confidence: 99%

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Wang

Zhao

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.

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“…The affected genes TCF4 and TCF8 express the transcription factors E2-2 and ZEB1 respectively, which are known to promote EMT 157,158 . TCF8 also alters the expression of Collagen IV, which is abundant in DM 159 .…”

Section: Dysfunction Of the Corneal Endotheliummentioning

confidence: 99%

Biomechanical relationships between the corneal endothelium and Descemet's membrane

Ali

Raghunathan

et al. 2016

Experimental Eye Research

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The posterior face of the cornea consists of the corneal endothelium, a monolayer of cuboidal cells that secrete and attach to Descemet’s membrane, an exaggerated basement membrane. Dysfunction of the endothelium compromises the barrier and pump functions of this layer that maintain corneal deturgesence. A large number of corneal endothelial dystrophies feature irregularities in Descemet’s membrane, suggesting that cells create and respond to the biophysical signals offered by their underlying matrix. This review provides an overview of the bidirectional relationship between Descemet’s membrane and the corneal endothelium. Several experimental methods have characterized a richly topographic and compliant biophysical microenvironment presented by the posterior surface of Descemet’s membrane, as well as the ultrastructure and composition of the membrane as it builds during a lifetime. We highlight the signaling pathways involved in the mechanotransduction of biophysical cues that influence cell behavior. We present the specific example of Fuchs’ Corneal Endothelial Dystrophy as a condition in which a dysregulated Descemet’s membrane may influence the progression of disease. Finally, we discuss some disease models and regenerative strategies that may facilitate improved treatments for corneal dystrophies.

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Functional Impact ofZEB1Mutations Associated With Posterior Polymorphous and Fuchs' Endothelial Corneal Dystrophies

Cited by 32 publications

References 40 publications

Phytomonas: Trypanosomatids Adapted to Plant Environments

Phytomonas: Trypanosomatids Adapted to Plant Environments

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Biomechanical relationships between the corneal endothelium and Descemet's membrane

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