Functional Impairment of Protein C Activity during Haemodialysis - A New Mechanism of Extracorporeal Thrombogenesis

Knudsen, Flemming; Sørensen, Per; Nielsen, Arne Høj; Dyerberg, Jørn

doi:10.1159/000169598

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…This inhibitor has been partially characterised [26]. One report has also suggested that haemodialysis membranes may also functionally impair the activity of PC [13].…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in critically ill patients: the effect of haemofiltration

Cardigan

McGloin

Mackie

et al. 1998

Intensive Care Medicine

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“…This inhibitor has been partially characterised [26]. One report has also suggested that haemodialysis membranes may also functionally impair the activity of PC [13].…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in critically ill patients: the effect of haemofiltration

Cardigan

McGloin

Mackie

et al. 1998

Intensive Care Medicine

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“…The controversies related to previous studies in plasma AT III may arise from (a) the difference in assay methods or (b) the possible discrepancy between the immunologi cal and functional activities of these natural coagulant inhibitors in uremia. Functional impairment of PC activ ity during hemodialysis has recently been reported thus suggesting a possible new mechanism of extracorporeal thrombogenesis [23]. Clinical data of turnover of these natural coagulation inhibitors in CAPD patients are limited.…”

Section: Discussionmentioning

confidence: 99%

Protein C, Protein S, and Antithrombin III Levels in Patients on Continuous Ambulatory Peritoneal Dialysis and Hemodialysis

Lai¹,

Yin

Yuen

et al. 1990

Nephron

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Patients undergoing dialysis are subject to risk of thrombotic complications. We studied the plasma levels of natural coagulation inhibitors including protein C (PC), protein S (PS), and antithrombin III (AT III) in 20 patients on hemodialysis and 20 patients on continuous ambulatory peritoneal dialysis (CAPD). Total PS antigen, free PS antigen, immunological and functional activities of PC and AT III were measured. Hemodialysis patients had a higher total PS level but a lower free PS level compared with healthy controls. Both the immunological and functional activities of AT III in hemodialysis patients were significantly lower than those of controls. With the exception of total PS level, CAPD patients had comparable or even higher plasma level of natural coagulation inhibitors compared with healthy controls. Furthermore, the plasma levels of PC, PS, and AT III were significantly lower in hemodialysis patients compared with CAPD patients despite greater daily losses of PC, PS, and AT III through urinary and peritoneal routes in patients on CAPD treatment. Most of the AT III in the peritoneal dialysate was still functionally active but most of the PC was inactive. Our observations suggest an effective turnover and production of these natural coagulation inhibitors in patients on CAPD therapy but a similar compensatory mechanism does not operate efficiently in patients receiving hemodialysis.

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Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S

Clyne

Egberg

Lins

1995

Thrombosis Research

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Functional Impairment of Protein C Activity during Haemodialysis - A New Mechanism of Extracorporeal Thrombogenesis

Cited by 5 publications

References 10 publications

Endothelial dysfunction in critically ill patients: the effect of haemofiltration

Endothelial dysfunction in critically ill patients: the effect of haemofiltration

Protein C, Protein S, and Antithrombin III Levels in Patients on Continuous Ambulatory Peritoneal Dialysis and Hemodialysis

Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S

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