Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

Alder, Arne; Wilcke, Louisa; Pietsch, Emma; Thien, Heidrun von; Pažický, Samuel; Löw, Christian; Mesén-Ramírez, Paolo; Bachmann, Anna; Burda, Paul‐Christian; Kunick, Conrad; Sondermann, Holger; Wilson, Danny W.; Gilberger, Tim-Wolf

doi:10.1016/j.jbc.2022.102360

Cited by 3 publications

(1 citation statement)

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“…The piggyBac disruption of SAM in our mutant could result in derepression of the sexual master regulator and a subsequent hyperproducer gametocyte phenotype. While the exact role of another hyperproducer, PF3D7_1316000 (PfGSK3α), needs to be investigated, its isoform, PfGSK3β, was recently shown to be essential for gametocyte development and maturation ( 67 ).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

et al. 2023

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The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei

Jia,

Wang,

Wang

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Schwarzer,

Skorokhod

2024

IJMS

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Post-translational modifications (PTMs) are essential for regulating protein functions, influencing various fundamental processes in eukaryotes. These include, but are not limited to, cell signaling, protein trafficking, the epigenetic control of gene expression, and control of the cell cycle, as well as cell proliferation, differentiation, and interactions between cells. In this review, we discuss protein PTMs that play a key role in the malaria parasite biology and its pathogenesis. Phosphorylation, acetylation, methylation, lipidation and lipoxidation, glycosylation, ubiquitination and sumoylation, nitrosylation and glutathionylation, all of which occur in malarial parasites, are reviewed. We provide information regarding the biological significance of these modifications along all phases of the complex life cycle of Plasmodium spp. Importantly, not only the parasite, but also the host and vector protein PTMs are often crucial for parasite growth and development. In addition to metabolic regulations, protein PTMs can result in epitopes that are able to elicit both innate and adaptive immune responses of the host or vector. We discuss some existing and prospective results from antimalarial drug discovery trials that target various PTM-related processes in the parasite or host.

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Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

Cited by 3 publications

References 75 publications

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

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