Functional Ingredients and Medicinal Prospects of Ethanol Extract from Macrocybe lobayensis

Khatua, Somanjana; Acharya, Krishnendu

doi:10.5530/pj.2018.6.197

Cited by 15 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the radicals were permitted to react with the complexes at variable doses in 200 μL of the reaction mixture in a 96-well plate. The plate was kept shaking at moderate speed for about 10 s and absorbance was perceived at 750 nm (Bio–Rad iMarkTM Microplate Reader, USA) . For a positive control, ascorbic acid was used.…”

Section: Methodsmentioning

confidence: 99%

“…The plate was kept shaking at moderate speed for about 10 s and absorbance was perceived at 750 nm (Bio−Rad iMarkTM Microplate Reader, USA). 51 For a positive control, ascorbic acid was used. The activities of both complexes and standard were denoted by the EC 50 value or concentration required to obtain 50% antioxidant effect as determined by regression analysis.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

See 1 more Smart Citation

Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities

Chowdhury

Dasgupta

Khatua

et al. 2020

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Six zinc(II) complexes, namely, [Zn(HL 1 H)Cl 2 ] (1), [Zn(HL 1 H)Br 2 ] (2), [Zn 2 (HL 1 H) 2 (OH)I 2 ]•I (3), [Zn(HL 2 )-Cl] (4), [Zn 2 (HL 2 )Br 3 ] (5), and [Zn(HL 2 )I] (6) have been manufactured by using two homologous Schiff base ligands H 2 L 1 and H 2 L 2 for the purpose of perlustrating their phosphatase-like activity, antioxidant activity, and antibacterial activity. Complexes 1, 2, 4, and 5 have been reported earlier by us, whereas complexes 3 and 6 have been synthesized and structurally characterized by regular physicochemical methods The hydrolytic property of the six complexes has been evaluated by checking the hydrolysis of the P−O bond of a widely used substrate, namely, disodium salt of (para-nitrophenyl)phosphate (PNPP) in 97.5% (v/v) mixture of N,N-dimethylformamide and water (DMF−water). Complexes 2− 5 have profound efficiency toward hydrolysis of phosphate ester bonds, and complexes 1 and 6 were noted to be inactive toward hydrolysis. Complex 3 displayed the highest efficacy among the six complexes. Additionally, antioxidant and antibacterial activities of the complexes were studied thoroughly. A detailed study of their antioxidant property revealed that complex 3 manifested superior radical scavenging activity, thus exhibiting the highest antioxidant property. The antibacterial activity was tested using four investigating bacteria, specifically Listeria monocytogenes ATCC19111, Staphylococcus aureus ATCC 700699, Salmonella typhimurium ATCC 23564, and Escherichia coli ATCC 25922 by determining minimum inhibitory concentration (MIC) values using the microdilution method. Here as well, complex 3 exhibited the highest activity to both Gram positive and Gram negative bacteria. The chemistry behind these experimental findings has been manifested by shedding light upon the structural features of the complexes. The suitable choice of ligand H 2 L 1 where one methylene group is less than its homologous ligand and metal precursor (ZnI 2 ) imparts a unique hydroxo-bridged molecular geometry and 2D hydrogen bonding network which in turn probably enhances the hydrolytic and biological activities of complex 3.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities

Chowdhury

Dasgupta

Khatua

et al. 2020

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, owing to increasing demands for natural bioactive compounds in the pharmaceutical and food industries, it is imperative to use the mycelia of this fungus as a source of natural antioxidants. In Macrocybe lobayensis, an wild edible mushroom from the same locality, similar flavonoids content (10.95±0.89 μg QtE/mg) was observed, while the total phenol content in the same was way less (12.58 ±0.89 μg GAE/mg) like any other mushroom [42].…”

Section: Discussionmentioning

confidence: 64%

Isaria tenuipes Peck, an entomopathogenic fungus from Darjeeling Himalaya: Evaluation of in-vitro antiproliferative and antioxidant potential of its mycelium extract

Chhetri

Shahi

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: Isaria tenuipes is one of the potent species in the members of the genus Isaria, which is well reported to possess multiple bioactive substances of therapeutic importance. Therefore, an in vitro experimental study was carried to evaluate the bioactivities of the crude methanolic extract from the mycelium of this fungus. Methods: The fungus was authenticated through morphological characters and the species discrepancy was resolved using the nuclear rDNA ITS sequence. The methanolic extract was fingerprinted by FTIR. The antioxidant components in terms of total phenols and flavonoids were determined as gallic acid and quercetin equivalents respectively. Antioxidant activities of the methanolic extract was assessed using 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2, 2 /-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) radical cation (ABTS 0+), Fe 2+ chelating activity, and hydroxyl radical scavenging assays. Cytotoxicity of the extract was determined by [3-(4, 5-dimethylthiazol-2-yl)-2, 5diphenyltetrazolium bromide] (MTT) assay on three cancer cell lines: HeLa, HepG2, and PC3. Apoptosis was further studied by propidium iodide (PI) and Annexin-V/PI staining flow cytometric analysis. Anti-proliferation capacity was studied by colony-forming assay.

show abstract

“…5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-6-(3,4,5-trihydroxyoxan-2-yl)chromen-4-one named as isoxiafota glycoside has inhibitory effects on Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus , and Enterococcus faecalis ( 24 ). Farrerol can inhibit the growth of Staphylococcus aureus ( 25 ); however, pyrogallol and demethylwedelolactone (norwedelide) not only can inhibit the growth of Staphylococcus aureus but also can prevent the growth of Escherichia coli and Salmonella ( 26 , 27 ). Kaempferide, gallic acid, and taxifolin have good antibacterial effects on Staphylococcus aureus, Escherichia coli, dysentery bacilli, Pseudomonas aeruginosa , and Streptococcus ( 28 – 30 ).…”

Section: Discussionmentioning

confidence: 99%

Preparation, Antibacterial Potential, and Antibacterial Components of Fermented Compound Chinese Medicine Feed Additives

Zou

Huang²,

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

This experiment was conducted to compare the antibacterial ability and to identify the antibacterial components of different fermented compound Chinese medicine feed additives in order to develop one fermented compound Chinese medicine feed additive product that can effectively alleviate metritis, vaginitis, and mastitis of sows. The Oxford cup method and double dilution method were used to compare the antibacterial ability of three fermented compound Chinese medicine feed additives (A, B, and C). UHPLC-QE-MS-based untargeted metabolomics was used to identify the antibacterial components of fermented compound Chinese medicine feed additives. Results showed that among fermented compound Chinese medicine feed additives A, B, and C, additive A had the strongest ability to inhibit the growth of Staphylococcus aureus, Salmonella cholerae suis, Escherichia coli, and Streptococcus agalactiae. The MIC and MBC of additive A were the lowest for Staphylococcus aureus compared to that for the other three pathogens. The concentrations of 23 Chinese medicine ingredients (ellagic acid, guanine, camphor, L-valine, sinapine, dipropylphthalate, 3-hydroxy-5-isopropylidene-3,8-dimethyl-2,3,3a,4,5,8a-hexahydro-6(1H)-azulenone, 7-dihydroxy-2-(4-hydroxyphenyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-6-(3,4,5-trihydroxyoxan-2-yl)chromen-4-one, acetylcholine, farrerol, pyrogallol, ethyl gallate, demethylwedelolactone, methyl gallate, kaempferide, gallic acid, eriodictyol, threonic acid, inositol, 3′,4′,7-trihydroxyflavanone, taxifolin, asiatic acid, and isorhamnetin) in additive A were significantly (p < 0.05 or p < 0.01) higher than those in additive B, respectively. It is concluded that the mixture composed of 23 active components in fermented compound Chinese medicine feed additive A plays an important role in inhibiting the growth of Staphylococcus aureus, Salmonella cholerae suis, Escherichia coli, and Streptococcus agalactiae.

show abstract

Functional Ingredients and Medicinal Prospects of Ethanol Extract from Macrocybe lobayensis

Cited by 15 publications

References 22 publications

Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities

Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities

Isaria tenuipes Peck, an entomopathogenic fungus from Darjeeling Himalaya: Evaluation of in-vitro antiproliferative and antioxidant potential of its mycelium extract

Preparation, Antibacterial Potential, and Antibacterial Components of Fermented Compound Chinese Medicine Feed Additives

Contact Info

Product

Resources

About