Functional inhibition of erectile process in rats by indomethacin

Senbel, Amira

doi:10.1007/s00345-010-0600-0

Cited by 11 publications

(26 citation statements)

References 25 publications

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“…In the penile erectile process, PGI 2 and PGE 1 can bind to the endothelial PGI receptor (IP) [ 13 , 21 , 22 ] and PGE receptor (EP, mainly EP 2 /EP 4 ), [ 1 , 24 , 25 ] respectively, which activates Gs protein-coupled receptor. This will initiate adenylyl cyclase to increase intracellular cyclic adenosine monophosphate (cAMP) levels.…”

Section: Pgsmentioning

confidence: 99%

“…The elevated cAMP can finally stimulate protein kinase A (PKA) to induce cascade of phosphorylation and inhibit myosin light chain kinase, with a result of trabecular smooth muscle relaxation and vasodilation. [ 1 , 13 ] For this relaxant ability, PGI 2 has been regarded as a valid candidate for ED treatment, [ 13 ] whereas repeated intracavernous or intraurethral PGE 1 injection can increase neuronal and endothelial NOS proteins [ 25 , 26 ] to improve ED. [ 22 , 25 ] PGD 2 also produced modest relaxation of penile arteries via interaction with EP 2 and other receptors.…”

Section: Pgsmentioning

confidence: 99%

“…[ 1 , 13 ] For this relaxant ability, PGI 2 has been regarded as a valid candidate for ED treatment, [ 13 ] whereas repeated intracavernous or intraurethral PGE 1 injection can increase neuronal and endothelial NOS proteins [ 25 , 26 ] to improve ED. [ 22 , 25 ] PGD 2 also produced modest relaxation of penile arteries via interaction with EP 2 and other receptors. [ 22 ] Except the relaxant PGs, PGH 2 can also convert to TXA 2 and PGF 2α , which stimulate TXA [ 13 , 21 ] and PGF receptors, [ 25 ] respectively, to mediate contraction in human penile smooth muscle cells and arteries in various pathophysiological conditions.…”

Section: Pgsmentioning

confidence: 99%

“…[ 22 , 25 ] PGD 2 also produced modest relaxation of penile arteries via interaction with EP 2 and other receptors. [ 22 ] Except the relaxant PGs, PGH 2 can also convert to TXA 2 and PGF 2α , which stimulate TXA [ 13 , 21 ] and PGF receptors, [ 25 ] respectively, to mediate contraction in human penile smooth muscle cells and arteries in various pathophysiological conditions. [ 13 , 21 , 25 ] Meanwhile, hypercoagulability subsequent to the elevated TXA 2 plays a key initiating role in aging impotence [ 23 ] (Fig.…”

Section: Pgsmentioning

confidence: 99%

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Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Wu²,

Fu³

et al. 2018

Medicine

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Objective:There are various etiologies of erectile dysfunction (ED), including endothelial dysfunction, atherosclerosis, and chronic inflammation. Aspirin has a protective role against endothelial dysfunction and atherosclerosis, whease all non-steroidal anti-inflammatory drugs (NSAIDs) are known for their anti-inflammatory properties. However, association between the use of aspirin or non-aspirin NSAIDs and ED is controversial. Therefore, we reviewed this relationship.Methods:We systematically reviewed the pathophysiology of ED, physiological effect of prostaglandins, pharmacological action of NSAIDs, and clinical and basic research studies that evaluated the effect of aspirin or non-aspirin NSAIDs on ED.Results:The research studies that assessed association between aspirin or non-aspirin NSAIDs are limited, and only 12 articles have been published. One clinical and three basic studies have claimed that aspirin or non-aspirin NSAIDs are beneficial for ED by preserving nitric oxide synthase impairment or penile blood hypercoagulability. One basic and two clinical studies considered them as risk factors because they interfered with prostaglandin production. By contrast, four clinical studies showed irrelevant results after controlling various medical indications. In addition, the mechanical effect of aspirin or non-aspirin NSAIDs on the nitric oxide pathway is still controversial.Conclusions:The available research studies revealed that association between aspirin or non-aspirin NSAIDs and ED is controversial. Considering the high frequency of drug use, further clinical and basic investigations should be conducted to clarify their exact relationship.

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Section: Pgsmentioning

confidence: 99%

Section: Pgsmentioning

confidence: 99%

Section: Pgsmentioning

confidence: 99%

Section: Pgsmentioning

confidence: 99%

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Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Wu²,

Fu³

et al. 2018

Medicine

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“…In a recent report, ASA improved endothelium‐dependent vasorelaxation through increased bioavailability of NO (Tauseef et al ., ). On the other hand, indomethacin and diclofenac as nonsteroidal anti‐inflammatory drugs negatively affected the erectile process in rats due to reduction in the plasma level of NO (Senbel, ). nNOS is localised in penile autonomic nerves and arterioles.…”

Section: Introductionmentioning

confidence: 99%

Acetylsalicylic acid protects erectile function in diabetic rats

et al. 2013

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We aimed to evaluate the effect of acetylsalicylic acid (ASA) treatment on diabetes-induced erectile dysfunction. Adult male Sprague-Dawley rats were divided into four groups as follows: (i) control (C), (ii) diabetic (D), (iii) ASA-treated control (C+ASA) and (iv) ASA-treated diabetic (D+ASA) groups. In groups 2 and 4, diabetes was induced by injection of 35 mg kg(-1) streptozotocin. ASA (100 mg kg(-1) day(-1) , orally) was administrated to rats in groups 3 and 4 for 8 weeks. Both intracavernosal pressure (ICP) and mean arterial blood pressure (MAP) were measured in in vivo studies. In organ bath, the relaxation responses to acetylcholine (ACh), electrical field stimulation (EFS) and sodium nitroprusside were tested in corpus cavernosum (CC) strips. The mRNA expression for neuronal nitric oxide synthase (nNOS) was calculated using reverse transcription polymerase chain reaction technique. In in vivo experiments, diabetic rats displayed reduced ICP/MAP values, which were normalised with ASA treatment. The relaxant response to high-dose ACh and EFS at low frequencies (1-8 Hz) in CC strips from the D+ASA group were significantly higher when compared to the D group. Treatment with ASA normalised the raised mRNA expressions of nNOS in diabetic penile tissues. ASA may be involved in mRNA of protein synthesis of NO released from nonadrenergic and noncholinergic cavernosal nerve in diabetes.

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Evaluation of some prostaglandins modulators on rat corpus cavernosum in-vitro: Is relaxation negatively affected by COX-inhibitors?

Bassiouni

Daabees

Louedec

et al. 2019

Biomedicine & Pharmacotherapy

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Functional inhibition of erectile process in rats by indomethacin

Abstract: Indomethacin, and to a lower extent diclofenac, may adversely affect erectile responses in rats.

Cited by 11 publications

References 25 publications

Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Acetylsalicylic acid protects erectile function in diabetic rats

Evaluation of some prostaglandins modulators on rat corpus cavernosum in-vitro: Is relaxation negatively affected by COX-inhibitors?

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