Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia‐Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions

Nguyen, Thuy T.; Duong, Hien T. T.; Basuki, Johan Sebastian; Montembault, Véronique; Pascual, Sagrario; Guibert, Clément de; Fresnais, Jérôme; Boyer, Cyrille; Whittaker, Michael R.; Davis, Thomas P.; Fontaine, Laurent

doi:10.1002/anie.201306724

Cited by 136 publications

(99 citation statements)

References 64 publications

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“…For example, in the following study, the authors have designed a magnetic nanocarrier for thermo-chemotherapy composed of an iron oxide core functionalised with a ligand allowing the release of drug through a combination of click reactions. 175 The ligand contains a phosphonic acid group which gives a strong binding to the NPs, an alkyne group which allows a copper catalyzed 1,3-dipolar cycloaddition (CuAAC) with an azide. This reaction is used to link an azide terminated poly(ethylene oxide) monomethyl ether which provides biocompatibility, stability and antifouling property to the NPs.…”

Section: Core/shell Nanoparticlesmentioning

confidence: 99%

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

2014

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Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.

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Section: Core/shell Nanoparticlesmentioning

confidence: 99%

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

2014

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“…The metallic nature of the cores offers versatile combinations of minimal invasive therapy approaches, like photothermal ablation by exploiting the absorbance of light by the gold and magnetic hyperthermia by utilizing the superparamagnetic behavior of iron oxide [12,[25][26][27][28].…”

Section: A N U S C R I P Tmentioning

confidence: 99%

A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles

et al. 2015

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Au@Fe3O4 Janus particles (JPs) are heteroparticles with discrete domains defined by different materials. Their tunable composition and morphology confer multimodal and versatile capabilities for use as contrast agents and drug carriers in future medicine. Au@Fe3O4 JPs have colloidal properties and surface characteristics leading to interactions with proteins in biological fluids. The resulting protein adsorption layer ("protein corona") critically affects their interaction with living matter. Although Au@Fe3O4 JPs displayed good biocompatibility in a standardized in vitro situation, an in-depth characterization of the protein corona is of prime importance to unravel underlying mechanisms affecting their pathophysiology and biodistribution in vitro and in vivo. Here, we comparatively analyzed the human plasma corona of Au-thiol@Fe3O4-SiO2-PEG JPs (NH2-functionalized and non-functionalized) and spherical magnetite (Fe3O4-SiO2-PEG) particles and investigated its effects on colloidal stability, biocompatibility and cellular uptake. Label-free quantitative proteomic analyses revealed that complex coronas including almost 180 different proteins were formed within only one minute. Remarkably, in contrast to spherical magnetite particles with surface NH2 groups, the Janus structure prevented aggregation and the adhesion of opsonins. This resulted in an enhanced biocompatibility of corona sheathed JPs compared to spherical magnetite particles and corona-free JPs.

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“…N’Guyen et al (2013), made use of the thermoreversible Diels-Alder (rDA) reaction to achieve magnetically triggered drug release from iron oxide NPs. [50] Of note, the rDA is too slow below 90–110°C, but conjugated to the MNPs they saw release of their fluorescent probe with minimal increase in temperature in the medium, suggesting a greater local thermal effect. [50] Saint-Cricq et al (2015) used mesoporous silica nanoparticles with an iron oxide core and coated with a thermodegradable polymer that breaks with an elevation in temperature.…”

Section: Can Nanoscale Thermal Phenomena In the Vicinity Of Magnetmentioning

confidence: 99%

“…[50] Of note, the rDA is too slow below 90–110°C, but conjugated to the MNPs they saw release of their fluorescent probe with minimal increase in temperature in the medium, suggesting a greater local thermal effect. [50] Saint-Cricq et al (2015) used mesoporous silica nanoparticles with an iron oxide core and coated with a thermodegradable polymer that breaks with an elevation in temperature. [51] The polymer was conjugated with rhodamine 6G and they saw an increase in fluorescence signal.…”

Section: Can Nanoscale Thermal Phenomena In the Vicinity Of Magnetmentioning

confidence: 99%

Nanoscale Thermal Phenomena in the Vicinity of Magnetic Nanoparticles in Alternating Magnetic Fields

Chiu‐Lam

Rinaldi

2016

Adv Funct Materials

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Magnetic nanoparticles can be made to dissipate heat to their immediate surroundings in response to an applied alternating magnetic field. This property, combined with the biocompatibility of iron oxide nanoparticles and the ability of magnetic fields to penetrate deep in the body, makes magnetic nanoparticles attractive in a range of biomedical applications where thermal energy is used either directly to achieve a therapeutic effect or indirectly to actuate the release of a therapeutic agent. Although the concept of bulk heating of fluids and tissues using energy dissipated by magnetic nanoparticles has been well accepted and applied for several decades, many new and exciting biomedical applications of magnetic nanoparticles take advantage of heat effects that are confined to the immediate nanoscale vicinity of the nanoparticles. Until recently the existence of these nanoscale thermal phenomena had remained controversial. In this short review we summarize some of the recent developments in this field and emerging applications for nanoscale thermal phenomena in the vicinity of magnetic nanoparticles in alternating magnetic fields.

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Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia‐Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions

Cited by 136 publications

References 64 publications

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles

Nanoscale Thermal Phenomena in the Vicinity of Magnetic Nanoparticles in Alternating Magnetic Fields

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