Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study

Deng, Gary; Hou, Bob L.; Holodny, Andrei I.; Cassileth, Barrie R.

doi:10.1186/1472-6882-8-37

Cited by 81 publications

(61 citation statements)

References 35 publications

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“…11 A recent functional MRI study showed central nervous system imaging changes during acupuncture for xerostomia. 12 There are methodological problems with the existing literature. Standardisation is often not possible due to the common practice of using differing points in each patient; this prevents validation and creates variation between practitioners and subjects.…”

mentioning

confidence: 99%

Group Acupuncture to Relieve Radiation Induced Xerostomia: A Feasibility Study

Simcock¹,

Fallowfield

Jenkins

2009

Acupunct Med

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Background A distressing complication of radiotherapy treatment for head and neck cancer is xerostomia (chronic oral dryness). Xerostomia is difficult to treat conventionally but there are reports that acupuncture can help. We conducted a feasibility study to examine the acceptability of a standardised group acupuncture technique and adherence to group sessions, together with acceptability of the objective and subjective measurements of xerostomia. Methods 12 males with established radiation induced xerostomia were treated in three groups of four. Each received eight weekly sessions of acupuncture using four bilateral acupuncture points (Salivary Gland 2; Modified Point Zero; Shen Men and one point in the distal radial aspect of each index finger (LI1)). Sialometry and quality of life assessments were performed at baseline and at the end of treatment. A semi-structured interview was conducted a week after completing the intervention. Results Adherence to and acceptability of the treatment and assessments was 100%. There were objective increases in the amounts of saliva produced for 6/12 patients post intervention and the majority also reported subjective improvements. Mean quality of life scores for domains related to salivation and xerostomia also showed improvement. At baseline 92% (11/12) patients reported experiencing a dry mouth “quite a bit/very much” as compared to 42% (5/12) after the treatment. Qualitative data revealed that the patients enjoyed the sessions. Conclusion The pilot study shows that a standardised group technique is deliverable and effective. The tools for objective and subjective assessment are appropriate and acceptable. Further examination in a randomised trial is now warranted.

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confidence: 99%

Group Acupuncture to Relieve Radiation Induced Xerostomia: A Feasibility Study

Simcock¹,

Fallowfield

Jenkins

2009

Acupunct Med

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“…Neuroimaging signal change areas of acupuncture at LI-2 correlated to saliva production (Deng et al, 2008). …”

Section: Introductionmentioning

confidence: 99%

Activation of different cerebral functional regions following acupuncture at Bot H Taixi and Taichong acupoints and taixi acupointalone: An fMRI study

Wanga¹,

Zhenga²,

Gf³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…Deng et al used this sham acupuncture device in their study. 25 In the study, unilateral manual acupuncture stimulation at Erjian (LI-2), a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum, and sham acupuncture at an adjacent site induced neither activation nor deactivation. The results demonstrated that true acupuncture induced more saliva production than sham acupuncture.…”

Section: Appropriate Control Setting For Trials Of Acupuncturementioning

confidence: 99%

“…23 Acupuncture has been used to deal with xerostomia caused by various etiologies. It has been shown that acupuncture can increase salivary flow in healthy volunteers, 24,25 patients with Sjogren's syndrome, 26 and those with radiation-induced salivary gland damage. [27][28][29] Acupuncture may be a useful therapy for the treatment of radiation-induced xerostomia.…”

Section: Introductionmentioning

confidence: 99%

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

et al. 2012

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Background. Methods currently available to prevent and manage xerostomia which caused by radiotherapy in patients with head and neck caner have limited efficacy. Some studies suggest that acupuncture may be beneficial. Objectives. The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer. Methods. PUBMED, EMBASE, Cochrane Library, CBM, CAJD, Wan Fang database, and VIP Database for Chinese Technical Periodicals were electronically searched, in conjunction with further manual search for relevant articles. Studies that met the inclusion criteria were systematically evaluated. Results. Three randomized controlled trials (RCTs) investigating the therapeutic effect of acupuncture were included. One RCT on the preventive effect of acupuncture was found. Because of the considerable variation among included studies, meta-analysis was not possible. Two included RCTs used placebo controls, and both observed significant improvement in the salivary flow rates between acupuncture and control groups. However, no significant differences were found. Three included RCTs suggested that acupuncture for radiation-induced xerostomia can improve patients' subjective symptoms. The only study evaluating the preventive effect of acupuncture for radiation-induced xerostomia showed positive changes in salivary flow rates (both unstimulated and stimulated) and dry mouth -related symptoms. Acupuncture treatment was well tolerated by all patients and no severe adverse effects were seen. Conclusions. Insufficient evidence is available to judge whether acupuncture is safe and whether it is effective in preventing or treating radiation-induced xerostomia. Significant research remains to be done before acupuncture can be recommended for routine use in radiation-induced xerostomia.

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Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study

Abstract: Background: Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses.

Cited by 81 publications

References 35 publications

Group Acupuncture to Relieve Radiation Induced Xerostomia: A Feasibility Study

Group Acupuncture to Relieve Radiation Induced Xerostomia: A Feasibility Study

Activation of different cerebral functional regions following acupuncture at Bot H Taixi and Taichong acupoints and taixi acupointalone: An fMRI study

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

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