Functional magnetic resonance imaging in a single schizophrenia patient with voluntary control over auditory verbal hallucinations

Wei, Yarui; Wang, Xiaoxiao; Wang, Yanming; Qiu, Bensheng; Xia, Haisen; Zhang, Xulai; Li, Huawei; Wang, Ming; Chen, Lin

doi:10.1016/j.schres.2019.09.002

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…This heterogeneity poses a significant challenge to the characterization of the psychological and biological processes underlying the development of control over voice-hearing experiences. For example, non-engagement-based approaches, characterized by diverting attention away from voice-hearing, are likely to be subserved by very different neural mechanisms from engagementbased approaches, which directly manipulate the occurrence of voice-hearing events themselves 8,15,16 . The ability to measure these subtypes reliably is crucial for the identification of their neural substrates and the development of new treatments based upon this advancing knowledge.…”

Section: Introductionmentioning

confidence: 99%

Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales

Mourgues

Hammer

Fisher

et al. 2022

Schizophrenia Bulletin

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Auditory verbal hallucinations (AVH) frequently cause significant distress and dysfunction, and may be unresponsive to conventional treatments. Some voice-hearers report an ability to fully control the onset and offset of their AVH, making them significantly less disruptive. Measuring and understanding these abilities may lead to novel interventions to enhance control over AVH. Fifty-two voice-hearers participated in the pilot study. 318 participants with frequent AVH participated in the validation study. A pool of 59 items was developed by a diverse team including voice-hearers and clinicians. After the pilot study, 35 items were retained. Factorial structure was assessed with exploratory (EFA, n = 148) and confirmatory (CFA, n = 170) factor analyses. Reliability and convergent validity were assessed using a comprehensive battery of validated phenomenological and clinical scales. CFA on the final 18 items supported two factors for a Methods of Control Scale (5 items each, average ω = .87), and one factor for a Degree of Control Scale (8 items, average ω = .95). Correlation with clinical measures supported convergent validity. Degree of control was associated with positive clinical outcomes in voice-hearers both with and without a psychosis-spectrum diagnosis. Degree of control also varied with quality of life independently of symptom severity and AVH content. The Yale control over perceptual experiences (COPE) Scales robustly measure voice-hearers’ control over AVH and exhibit sound psychometric properties. Results demonstrate that the capacity to voluntarily control AVH is independently associated with positive clinical outcomes. Reliable measurement of control over AVH will enable future development of interventions meant to bolster that control.

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Section: Introductionmentioning

confidence: 99%

Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales

Mourgues

Hammer

Fisher

et al. 2022

Schizophrenia Bulletin

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“…The AVH group showed abnormal interhemispheric and/or intrahemispheric dFCD variability in the left MTG, left IFG, right ITG, and AN of the right thalamus. The upper regions are the pivotal components of auditory and language pathways (Acheson & Hagoort, 2013 ; Nauchi & Sakai, 2009 ; Opitz et al, 2002 ; Wahl et al, 2008 ) and highly associate with the neural mechanism of AVHs (Shergill et al, 2004 ; Silbersweig et al, 1995 ; Vercammen et al, 2011 ; Wei et al, 2020 ). Abnormal activations and connectivity in auditory and language pathways have highly linked to schizophrenia patients with AVHs (Benetti et al, 2015 ; Chang et al, 2017 ; Lavigne & Woodward, 2018 ; Steinmann et al, 2019 ; Xie et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug‐naïve first‐episode schizophrenia patients with auditory verbal hallucinations

Wei

Han

Chen

et al. 2022

Human Brain Mapping

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Numerous studies indicate altered static local and long‐range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown in schizophrenia patients with AVHs. We analyzed resting‐state functional magnetic resonance imaging data for drug‐naïve first‐episode schizophrenia patients, 50 with AVHs and 50 without AVH (NAVH), and 50 age‐ and sex‐matched healthy controls. Whole‐brain functional connectivity was decomposed into ipsilateral and contralateral parts, and sliding‐window analysis was used to calculate voxel‐wise interhemispheric and intrahemispheric dynamic functional connectivity density (dFCD). Finally, the correlation analysis was performed between abnormal dFCD variance and clinical measures in the AVH and NAVH groups. Compared with the NAVH group and healthy controls, the AVH group showed weaker interhemispheric dFCD variability in the left middle temporal gyrus ( p < .01; p < .001), as well as stronger interhemispheric dFCD variability in the right thalamus ( p < .001; p < .001) and right inferior temporal gyrus ( p < .01; p < .001) and stronger intrahemispheric dFCD variability in the left inferior frontal gyrus ( p < .001; p < .01). Moreover, abnormal contralateral dFCD variability of the left middle temporal gyrus correlated with the severity of AVHs in the AVH group ( r = −.319, p = .024). The findings demonstrate that abnormal temporal variability of interhemispheric and intrahemispheric dFCD in schizophrenia patients with AVHs mainly focus on the temporal and frontal cortices and thalamus that are pivotal components of auditory and language pathways.

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Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations

Perez-Rando,

García-Martí,

Escarti

et al. 2024

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Functional magnetic resonance imaging in a single schizophrenia patient with voluntary control over auditory verbal hallucinations

Cited by 5 publications

References 6 publications

Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales

Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales

Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug‐naïve first‐episode schizophrenia patients with auditory verbal hallucinations

Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations

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