Functional Magnetic Resonance Imaging of the Effects of Low-frequency Transcutaneous Electrical Nerve Stimulation on Central Pain Modulation

Koçyiğit, Figen; Akalin, Elif; Gezer, Naciye Sinem; Orbay, Özge; Koçyi̇ği̇t, Ali̇; Ada, Emel

doi:10.1097/ajp.0b013e31823c2bd7

Cited by 34 publications

(22 citation statements)

References 24 publications

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“…Electroanalgesia finds its theoretical underpinnings in the GCT . One study evaluated the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) in alleviating shoulder pain . Subjects were monitored via functional MRI while TENS was administered .…”

Section: Electrical Modulation Of Pain (Electroanalgesia)mentioning

confidence: 99%

“…7,71 One study evaluated the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) in alleviating shoulder pain. 72 Subjects were monitored via functional MRI while TENS was administered. 72 Researchers found a statistically significant decrease in perceived pain intensity and pain-specific activation of pain processing structures.…”

Section: Electrical Modulation Of Pain (Electroanalgesia)mentioning

confidence: 99%

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Therapeutic Basis of Clinical Pain Modulation

Kirkpatrick

McEntire

Hambsch

et al. 2015

Clinical Translational Sci

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Pain is a hallmark of almost all bodily ailments and can be modulated by agents, including analgesics and anesthetics that suppress pain signals in the central nervous system. Defects in the modulatory systems, including the endogenous pain-inhibitory pathways, are a major factor in the initiation and chronicity of pain. Thus, pain modulation is particularly applicable to the practice of medicine. This review summarizes the existing literature on pain modulation. Here, we critically reviewed the literature from PubMed on pain modulation published primarily within last 5 years in high impact journals. Specifically, we have discussed important anatomical landmarks of pain modulation and outlined the endogenous networks and underlying mechanisms of clinically relevant pain modulatory methods. The Gate Control Theory is briefly presented with discussion on the capacity of pain modulation to cause both hyper- and hypoalgesia. An emphasis has been given to highlight key areas in pain research that, because of unanswered questions or therapeutic potential, merit additional scientific scrutiny. The information presented in this article would be helpful in developing novel therapies, metrics, and interventions for improved patient management.

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Section: Electrical Modulation Of Pain (Electroanalgesia)mentioning

confidence: 99%

Section: Electrical Modulation Of Pain (Electroanalgesia)mentioning

confidence: 99%

Therapeutic Basis of Clinical Pain Modulation

Kirkpatrick

McEntire

Hambsch

et al. 2015

Clinical Translational Sci

View full text Add to dashboard Cite

show abstract

“…This suggests that fMRI can provide a means of identifying the brain mechanisms associated with TENS pain relief. In two recent studies of post-TENS effects in patients with carpal tunnel syndrome and subacromial impingement syndrome (Kara et al, 2010;Kocyigit et al, 2012), activations of the sensory cortex, caudal anterior cingulate cortex and parahippocampal cortex were decreased after TENS application. In two recent studies of post-TENS effects in patients with carpal tunnel syndrome and subacromial impingement syndrome (Kara et al, 2010;Kocyigit et al, 2012), activations of the sensory cortex, caudal anterior cingulate cortex and parahippocampal cortex were decreased after TENS application.…”

Section: Introductionmentioning

confidence: 96%

Brain mechanisms of pain relief by transcutaneous electrical nerve stimulation: A functional magnetic resonance imaging study

Choi

Kim

Kang

et al. 2015

European Journal of Pain

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“…[21,22] A common feature of these techniques is direct manipulation of the lesion site. All of these techniques have been used with varying degrees of success in the management of chronic shoulder pain.…”

Section: Discussionmentioning

confidence: 99%

Comparing complementary alternative treatment for chronic shoulder pain of myofascial origin

Pan

Hsu²,

Wong

et al. 2016

Medicine

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The aim of this study was to compare the short-term outcomes between 2 different treatments for unilateral chronic shoulder pain of myofascial origin, that is, local tender area related meridians (LTARMs) treatment and collateral meridian therapy (CMT), which were performed 6 times over a period of 4 weeks.Seventy patients with unilateral shoulder pain of chronic myofascial origin were enrolled. The patients were randomly assigned to 2 different treatment groups: 1 group received CMT (n = 35) and the other received LTARM (n = 35). Before and after the 2 treatment processes, all patients rated their overall pain intensity on a visual analogue scale (VAS) and a validated 13-question shoulder pain and disability index (SPADI) questionnaire was used to measure shoulder pain and functional impairment after therapy for 4 weeks.After CMT, the pain intensity was reduced after CMT. VAS score is reduced from 5.90 ± 2.07 (a mean of 5.90 and standard deviation of 2.07) to 3.39 ± 1.2. This was verified by the SPADI pain subscale scores (from 0.58 ± 0.193 to 0.33 ± 0.14). The pain-relief effect of CMT was significantly better than that of LTARM (VAS score from 5.78 ± 1.64 to 4.58 ± 1.40; P < 0.005; SPADI pain subscale score from 0.58 ± 0.16 to 0.45 ± 0.14, P < 0.001). In addition, the VAS scores of patients changed considerably in the CMT group after 4 weeks of treatment, where 63% of patients felt no or mild pain, whereas the VAS scores for moderate pain were even higher in the LTARM group in 75% of patients (P < 0.001). Moreover, the SPADI disability subscale scores improved significantly in the CMT group because of their greater mobility associated with shoulder impairment (disability score: from 0.58 ± 0.20 to 0.35 ± 0.14) than those in the LTARM group (disability score: from 0.55 ± 0.17 to 0.44 ± 0.14, P < 0.001).CMT may be more effective in reducing chronic shoulder pain of myofascial origin than the LTARM treatment, where treatment with the former resulted in better functional recovery after 4 weeks than the latter.

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Functional Magnetic Resonance Imaging of the Effects of Low-frequency Transcutaneous Electrical Nerve Stimulation on Central Pain Modulation

Abstract: We suggest that a 1-session low-frequency TENS may induce analgesic effect through modulation of discriminative, affective, and motor aspects of central pain perception.

Cited by 34 publications

References 24 publications

Therapeutic Basis of Clinical Pain Modulation

Therapeutic Basis of Clinical Pain Modulation

Brain mechanisms of pain relief by transcutaneous electrical nerve stimulation: A functional magnetic resonance imaging study

Comparing complementary alternative treatment for chronic shoulder pain of myofascial origin

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