2013
DOI: 10.7196/samj.6336
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Functional MRI language mapping in pre-surgical epilepsy patients: Findings from a series of patients in the Epilepsy Unit at Mediclinic Constantiaberg

Abstract: Background. Functional magnetic resonance imaging (fMRI) is commonly applied to study the neural substrates of language in clinical research and for neurosurgical planning. fMRI language mapping is used to assess language lateralisation, or determine hemispheric dominance, and to localise regions of the brain involved in language. Routine fMRI has been introduced in the Epilepsy Unit at Mediclinic Constantiaberg to contribute to the current functional mapping procedures used in pre-surgical planning. Method. I… Show more

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Cited by 6 publications
(12 citation statements)
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“…It would therefore appear that the language network is particularly vulnerable to chronic epileptic activity. Moreover, an inter-hemispheric dissociation of frontal and temporal language regions in patients with focal epilepsy has also been described [10,11,20,42-44]. In a previous study, 29 (20.1%) out of 144 patients with medically intractable complex-partial seizures showed bilateral language representation after intracarotid amobarbital test assessment [10] and more importantly, 4 (2.8%) of these patients -2 of them with TLE- had strong evidence of an interhemispheric dissociation of expressive and receptive language functions.…”
Section: Discussionmentioning
confidence: 99%
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“…It would therefore appear that the language network is particularly vulnerable to chronic epileptic activity. Moreover, an inter-hemispheric dissociation of frontal and temporal language regions in patients with focal epilepsy has also been described [10,11,20,42-44]. In a previous study, 29 (20.1%) out of 144 patients with medically intractable complex-partial seizures showed bilateral language representation after intracarotid amobarbital test assessment [10] and more importantly, 4 (2.8%) of these patients -2 of them with TLE- had strong evidence of an interhemispheric dissociation of expressive and receptive language functions.…”
Section: Discussionmentioning
confidence: 99%
“…Surprisingly, only a few studies of epilepsy sufferers have used pure passive tasks such as listening to standard speech [11,20,21]. Passive listening paradigms reliably activate the receptive language cortex [22] making it possible to determine hemispheric dominance and identify the areas involved in language processing of TLE patients, which is of the utmost importance in pre-surgical language mapping [10,11].…”
Section: Introductionmentioning
confidence: 99%
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