Functional MRI of pain application in youth who engaged in repetitive non-suicidal self-injury vs. psychiatric controls

Osuch, Elizabeth A.; Ford, Kristen A.; Wrath, Andrew J.; Bartha, Robert; Neufeld, Richard W. J.

doi:10.1016/j.pscychresns.2014.05.003

Cited by 103 publications

(71 citation statements)

References 34 publications

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“…Similar limbic hyperactivity has been reported among self-injuring patients during processing of emotional stimuli in prior research (Davis et al, 2014; Osuch et al, 2014; Plener et al, 2012). Prior research suggests amygdala activation is more reliably elicited by negative stimuli (Dickstein and Leibenluft, 2006; Phillips et al, 2003a) or threatening experiences (Ochsner et al, 2012), though this region is active during processing of highly relevant or emotionally salient stimuli, regardless of emotional valence (Cunningham and Brosch, 2012).…”

Section: Discussionsupporting

confidence: 84%

The neurobiology of self-knowledge in depressed and self-injurious youth

Quevedo

Martin

Scott

et al. 2016

Psychiatry Research: Neuroimaging

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There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, the salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests the neural basis of social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: NSSI plus depression diagnosis (NSSI), depression only (DEP), healthy controls (HC). In the scanner, participants completed an Interpersonal Self-Processing task by taking direct (own) and indirect (mothers’, best friends’, or classmates’) perspectives regarding self-characteristics. Across all perspectives, NSSI showed higher BOLD activation in limbic areas, and anterior and posterior cortical midline structures versus DEP and HC, while HC showed greater activity in rostrolateral, frontal pole and occipital cortex than NSSI and DEP youth. Moreover, NSSI youth showed heightened responses in amygdala, hippocampus, parahippocampus, and fusiform when taking their mothers’ perspective, which were negatively correlated with self-reports of the mother’s support of adolescents’ emotional distress in the NSSI group. NSSI youth also yielded greater precuneus and posterior cingulate cortex activity during indirect self-processing from their classmates’ perspective. Findings suggest a role for disruptions in self- and emotion-processing, and conflicted social relationships in the neurobiology of NSSI among depressed adolescents.

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Section: Discussionsupporting

confidence: 84%

The neurobiology of self-knowledge in depressed and self-injurious youth

Quevedo

Martin

Scott

et al. 2016

Psychiatry Research: Neuroimaging

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“…Furthermore, because ǵ9-tetrahydrocannabinol (THC) has analgesic properties (Borgelt et al, 2013), as do the endocannabinoids (Woodhams et al, 2015), which interface with THC during neurotransmitter signaling, it is theoretically possible that early exposure to THC modifies pain perception and contributes directly to the risk for NSSI, although given the typically low frequency of cannabis use before age 17 years in this sample, we consider this improbable. Functional neuroimaging research also provides evidence for alteration of neural pathways associated with pain processing among individuals reporting NSSI and borderline personality disorder, of which NSSI is a prominent feature (Kluetsch et al, 2012;Osuch et al, 2014). However, we are skeptical about positing potential causal effects with these cross-sectional data.…”

Section: Discussionmentioning

confidence: 99%

Cannabis Involvement and Nonsuicidal Self-Injury: A Discordant Twin Approach

Few

Grant

Nelson

et al. 2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Cannabis use, particularly at an early age, has been linked to suicidal thoughts and behavior, but minimal work has examined the association between cannabis use and lifetime nonsuicidal self-injury (NSSI). The current study aims to characterize the overlap between lifetime and early cannabis use and NSSI and to examine genetic and environmental mechanisms of this association. Method: Adult male and female twins from the Australian Twin Registry (N = 9,583) were used to examine the odds of NSSI associated with lifetime cannabis use and early cannabis use (i.e., <17 years of age). These associations were also examined within monozygotic (MZ) twins discordant for cannabis use and MZ twins discordant for early cannabis use. Analyses were replicated in an independent sample of female twins (n = 3,787) accounting for the age at onset of cannabis use and NSSI. Conclusions:Results suggest that NSSI is associated with cannabis involvement via differing mechanisms. For lifetime cannabis use, the lack of association in discordant pairs suggests the role of shared genes and family environment. However, in addition to such shared familial influences, person-specific and putatively causal factors contribute to the relationship between early cannabis use and NSSI. Therefore, delaying the onset of cannabis use may reduce exposure to influences that exacerbate vulnerabilities to NSSI. (J. Stud. Alcohol Drugs, 77, 873-880, 2016)

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“…One study in adolescents with BPD showed elevated pain thresholds [52]. In another study in youth (aged 16–24) with comparable rates of BPD in both the NSSI and the clinical control group, no differentiation with regard to pain threshold or processing of physical pain was shown [53]. However, differences during pain offset were shown in behavioral data (higher reported feelings of relief), as well as in neuroimaging data (in reward-related areas [53]).…”

Section: Etiology and Risk Factorsmentioning

confidence: 99%

“…In another study in youth (aged 16–24) with comparable rates of BPD in both the NSSI and the clinical control group, no differentiation with regard to pain threshold or processing of physical pain was shown [53]. However, differences during pain offset were shown in behavioral data (higher reported feelings of relief), as well as in neuroimaging data (in reward-related areas [53]). Pain offset relief (i.e., the removal of physical pain) has been associated with a simultaneous beneficial effect on emotions [54].…”

Section: Etiology and Risk Factorsmentioning

confidence: 99%

Non-suicidal Self-Injury in Adolescence

Brown

Plener

2017

Curr Psychiatry Rep

321

187

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Purpose of ReviewNon-suicidal self-injury (NSSI) is a common mental health threat among adolescents. This review aims to present the current literature on epidemiology, etiology, and therapeutic approaches with a focus on the period of adolescence.Recent FindingsNSSI is widespread among adolescents both in community as well as in clinical settings with lifetime prevalence rates between 17 and 60% in recent studies. It is influenced by multiple factors including social contagion, interpersonal stressors, neurobiological background, as well as emotional dysregulation and adverse experiences in childhood.SummaryThere is still a lack of studies regarding the psychotherapeutic as well as the psychopharmacological treatment of NSSI in adolescence. Furthermore, sufficient evidence for prevention programs is missing.

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Functional MRI of pain application in youth who engaged in repetitive non-suicidal self-injury vs. psychiatric controls

Cited by 103 publications

References 34 publications

The neurobiology of self-knowledge in depressed and self-injurious youth

The neurobiology of self-knowledge in depressed and self-injurious youth

Cannabis Involvement and Nonsuicidal Self-Injury: A Discordant Twin Approach

Non-suicidal Self-Injury in Adolescence

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