Functional MRI response and correlated electrophysiological changes during posterior hypothalamic nucleus deep brain stimulation

Young, Calvin K.; Brown, Andrew R.; Robinson, Jordan H.B.; Tuor, Ursula I.; Dunn, Jeff F.; Bland, Brian H.; Teskey, G. Campbell

doi:10.1016/j.neuroimage.2011.02.023

Cited by 23 publications

(16 citation statements)

References 69 publications

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“…Although average results suggested a small increase, no significant short-term (up to 9 min; Fig.6a) or long-term (up to 60 min; Fig.6b) effects were observed of turning on the stimulation. This is in apparent contrast to our previous results with cFos and also to a number of previously reported increases in BOLD or CBV responses in brain areas distant from various DBS (Albough et al, 2016;Chao et al, 2014;Lai et al, 2013;Van Den Berge et al, 2017;Young et al, 2011). However, we must…”

Section: Discussioncontrasting

confidence: 99%

Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice

Bazzu

Serra

Hamelink

et al. 2019

Journal of Neuroscience Methods

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Section: Discussioncontrasting

confidence: 99%

Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice

Bazzu

Serra

Hamelink

et al. 2019

Journal of Neuroscience Methods

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“…In many animal models and clinical treatments, bilateral DBS is widely used in the treatment of movement disorders and psychiatric diseases (Martinez-Rivera et al, 2016;Wade et al, 2016;Zhou et al, 2011), while several clinical reports and imaging studies suggested that unilateral DBS would exert bilateral effects and had a similar successful results (Huff et al, 2010;Taba et al, 2010;Young et al, 2011). So we would like to choose the unilateral NAc DBS for ease of operation.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention

Zhang

Cui

Wang

et al. 2017

Experimental Neurology

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“…Correspondence and material requests should be addressed to Andreas Horn (andreas.horn@charite.de). Table S1: Studies on DBS-induced modulation of resting-state functional connectivity in PD (Gratwick e et al , 2018), (Mueller et al , 2018), (Saenger et al , 2017), (Holi ga et al, 2015), (Knight et al, 2015), (Jos hua Kahan et al, 2014), (Mueller et al , 2013), (Jech et al ., 2012), (J osh Kahan et al , 2012), (Phillips et al , 2006), (Hesselm ann et al , 2004), (Stefur ak et al, 2003), (J ech et al, 2001), (Mi n et al, 2014), (Min et al, 2012), (Lee et al, 2011), (Lai et al ., 2015), (C hao et al , 2014), , , (Lai et al , 2014), (Young et al , 2011) 1-3 days post lead implantation STN-DBS induced higher interconnectedness (i.e., EC) of left and right motor cortex and increased connectivity of these regions with thalamus and cerebellum in seed-based analysis.…”

Section: Author Contributionsmentioning

confidence: 99%

Modulating the human functional connectome using deep brain stimulation

Horn

Wenzel

Irmen

et al. 2019

Preprint

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Neuroimaging has seen a paradigm shift from a formal description of local activity patterns toward studying distributed brain networks. The recently defined framework of the 'human connectome' allows to globally analyse parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with severe movement disorders aiming to retune abnormal brain network activity by local high frequency stimulation of the basal ganglia. Beyond clinical utility, DBS represents a powerful research platform to study functional connectomics and the modulation of distributed brain networks in the human brain. We acquired resting-state functional MRI in twenty Parkinson's disease (PD) patients with subthalamic DBS switched ON and OFF. An age-matched control cohort of fifteen subjects was acquired from an open data repository. DBS lead placement in the subthalamic nucleus (STN) was localized using a state-of-the art pipeline that involved brain shift correction, multispectral image registration and use of a precise subcortical atlas. Based on a realistic 3D model of the electrode and surrounding anatomy, the amount of local impact of DBS was estimated using a finite element method approach. On a global level, average connectivity increases and decreases throughout the brain were estimated by contrasting ON and OFF DBS scans on a voxel-wise graph comprising eight thousand nodes. Local impact of DBS on the motor STN explained half the variance in global connectivity increases within the motor network (R = 0.711, p < 0.001). Moreover, local impact of DBS on the motor STN could explain the degree of how much voxel-wise average brain connectivity normalized toward healthy controls (R = 0.713, p < 0.001). Finally, a network based statistics analysis revealed that DBS attenuated specific couplings that are known to be pathological in PD. Namely, coupling between motor thalamus and motor cortex was increased and striatal coupling with cerebellum, external pallidum and STN was decreased by DBS.Our results show that rs-fMRI may be acquired in DBS ON and OFF conditions on clinical MRI hardware and that data is useful to gain additional insight into how DBS modulates the functional connectome of the human brain. We demonstrate that effective DBS increases overall connectivity in the motor network, normalizes the network profile toward healthy controls and specifically strengthens thalamo-cortical connectivity while reducing striatal control over basal ganglia and cerebellar structures.

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Functional MRI response and correlated electrophysiological changes during posterior hypothalamic nucleus deep brain stimulation

Cited by 23 publications

References 69 publications

Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice

Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice

RETRACTED: Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention

Modulating the human functional connectome using deep brain stimulation

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