Functional One‐Dimensional Nanomaterials: Applications in Nanoscale Biosensors

Chopra, Nitin; Gavalas, Vasilis G.; Hinds, Bruce J.; Bachas, Leonidas G.

doi:10.1080/00032710701567170

Cited by 94 publications

(50 citation statements)

References 184 publications

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“…The nanostructures of metal oxide semiconductors are attractive and important for nanosensors research because of their practical and theoretical importance in biological, environmental science and analytical chemistry applications [28][29][30][31]. The semiconducting, piezoelectric and pyroelectric properties of one dimension metal oxide NSs are very important.…”

Section: Metal Oxide Semiconductor Nanostructuresmentioning

confidence: 99%

“…The most popular research areas of these nanostructures are optoelectronics [31], sensors [32], and actuators [33]. Metal oxide NSs have a high surface area to volume ratio, low toxicity, are environment-friendly, have chemical stability and biocompatibility.…”

Section: Metal Oxide Semiconductor Nanostructuresmentioning

confidence: 99%

“…So metal oxide NSs also show fast electron transfer properties required to improve nanomaterials performance when used as a biomimetic membrane that will detect e.g. proteins and retain their activity [29,31,32]. [35,36], electrochemical deposition (ED) [37], and hydrothermal methods [38,39].…”

Section: Metal Oxide Semiconductor Nanostructuresmentioning

confidence: 99%

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Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Khun¹

2015

Linköping Studies in Science and Technology. Dissertations

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Research on nanomaterials has been revolutionized in the last few years because of the attractive properties they have in comparison to the bulk phase of similar materials. These properties are physical, chemical, catalytic and optical. Among these nanomaterials, the metal oxide nanostructures have become of particular interest to scientists for the development of different optical, biochemical and biomedical nanodevices. In the present research work using the advantageous features of nanotechnology, high performance nanodevices for optoelectronics with a wide band gap compound nanostructure and highly sensitive sensor devices have been demonstrated. The nanotechnology is used to fabricate sensitive and precise nanodevices based on nanomaterials for the application of sensing.Among metal oxide nanostructures, ZnO, CuO and NiO are attractive materials because of their unique properties; their high surface area to volume ratio, their energy band gap of 3.37 eV, 1.2 eV and 3.7 eV, respectively, biocompatibility, high electron mobility, fast electron transfer rate and they are environmental-friendly in many applications. When used in sensor devices, nanomaterials have indicated high selectivity for possible use to detect the various analytes even in small volumes. Metal oxide nanostructures have shown to be good for optoelectronic nanodevices because of their electrical characteristics, high optical absorption and low-processing temperature.In this thesis, the synthesis of different morphologies of metal oxide semiconductor nanostructures and their composite using the hydrothermal method are demonstrated for various applications. This thesis is divided into three parts:In the first part of this research work, the fabrication of well-aligned ZnO nanorods using different concentrations of composite seed layer of inorganic and organic materials when using the hydrothermal growth method is presented. The effect of the composite seed layer on the i Abstract alignment, density and optical properties of the grown ZnO nanorods is investigated (paper I).Utilizing the advantage of ZnO nanostructure, a comparative study of ZnO nanorods and thin films for chemical and biosensing application was carried out. The ZnO nanorods and thin films were functionalized with strontium ionophore membrane, immobilized the galactose oxidase and lactate oxidase for determining the strontium ions, D-galactose and L-lactic acid, respectively (paper II).In the second part, the effects of different urea concentrations on the morphology of CuO nanostructures is studied as described in paper III. Moreover, CuO nanoflowers were functionalized with cadmium ion ionophore for the detection of Cd ions, while CuO nanosheets were grown by the low temperature growth method and were used for the development of a nonenzymatic glucose sensor, respectively (Paper IV).In the last part of this thesis, composite nanostructures of CuO/ZnO and NiO/ZnO were applied to develop dopamine sensor and fast sensitive UV photodetector, respectively. A nanohybrid of C...

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Section: Metal Oxide Semiconductor Nanostructuresmentioning

confidence: 99%

Section: Metal Oxide Semiconductor Nanostructuresmentioning

confidence: 99%

See 1 more Smart Citation

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Khun¹

2015

Linköping Studies in Science and Technology. Dissertations

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“…Metal nano particles possess high surface area, chemical stability and shows fast electron communication features [15]. The high electron communication features, high surface to volume ratio and electro-catalytic activity of the nanosized materials make them ideal as immobilization matrices, as transduction platform and/or mediators.…”

Section: Introductionmentioning

confidence: 99%

Development of Nanoprobe for the Determination of Blood Cholesterol

Jeyashanthi-Navamani¹

2012

J Biosens Bioelectron

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Measurements of serum cholesterol levels are important in the diagnosis and classification of hyper lipoproteinemias. Elevated cholesterol levels may occur with hypothyroidism, nephrotic syndrome, diabetes, and various liver diseases. The present investigation was carried out for the development of rapid, highly sensitive and economic cholesterol biosensor for the determination of blood cholesterol. The PVP encapsulated ZnS nanoparticals have been synthesized and characterized by Fourier Transform InfraRed (FTIR) spectroscopy, UV-visible spectroscopy, and Atomic force microscopy techniques in the present investigation. The size of the nanoparticles is found to be ranging between 21-22 nm.The surface morphology of the sensing area of functionalized MWCNT was examined using Scanning Electron Microscopy (SEM). The length of the MWCNTs is found to be approximately 2 microns. In the IR spectrum of functionalized MWCNTs, the presence of bands at 1636 cm -1 and 3434 cm -1 confirmed the presence of carbonyl and hydroxyl moieties of carboxylic acid group.Cholesterol Oxidase was immobilized on to the ZnS nanoparticles and Multiwall Carbon Nanotubes (MWCNTs) which they were placed on a glassy carbon electrode surface using Nafion by LBL assembly technique. Cyclic voltammetric study reveals that the fast electron transfer between electrodes was achieved through the incorporation of ChOx into the Nafion-ZnS-MWCNTs film. ZnS and MWCNTs played an important role in facilitating the electron transfer between the ChOx and the electrode surface.The cholesterol bioelectrode shows detection range of 10-450 mg/dl and good linearity is obtained in 50-450 mg/dl (1.3 -11.6 mM) range with linear regression coefficient 'R2' as 0.986. The Michaelis-Menten constant K m value obtained as 0.84 mM using Lineweaver-Burke plot by plotting 1/V vs 1/Conc. The low K m value 0.84 mM indicates high affinity of immobilized ChOx to cholesterol. It exhibits optimum pH 7.0 and optimum temperature 35°C. Therefore, the bioelectrode fabricated in this study is promising for cholesterol detection in human blood.

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“…Among the broad range of nanomaterials that are currently being investigated for bioapplications, one dimensional (1D) nanostructures have received special attention due to their variable aspect ratio leading to tunable properties [5][6][7]. In particular, nickel nanowires (NiNW) exhibit ferromagnetic properties that allow easy magnetic manipulation at low external magnetic fields, thus appearing as good candidates for several biomedical applications, including cell manipulation and separation [8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

Pinheiro

Sousa

Araújo

et al. 2013

Journal of Colloid and Interface Science

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This work reports research on the development of bimodal magnetic and fluorescent 1D nanoprobes. First, ferromagnetic nickel nanowires (NiNW) have been prepared by Ni electrodeposition in anodic aluminum oxide (AAO) template. The highly ordered self-assembled AAO nanoporous templates were fabricated using a two-step anodization method of aluminum foil. The surface of the NiNW were then modified with polyethyleneimine (PEI) which was previously labeled with an organic dye (fluorescein isothiocyanate: FITC) via covalent bonding. The ensuing functionalized NiNW exhibited the characteristic green fluorescence of FITC and could be magnetically separated from aqueous solutions by using a NdFeB magnet. Finally, the interest of these bimodal NiNW as nanoprobes for in vitro cell separation and biolabeling was preliminary assessed in a proof of principle experiment that involved the attachment of biofunctionalized NiNW to blood cells.

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Functional One‐Dimensional Nanomaterials: Applications in Nanoscale Biosensors

Cited by 94 publications

References 184 publications

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Development of Nanoprobe for the Determination of Blood Cholesterol

Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

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