Functional Organization of the Internal Medullary Lamina in Man

Sano, Keiji; Yoshioka, Minoru; Sekino, Hiroaki; Mayanagi, Yoshiaki; Yoshimasu, Norio; Tsukamoto, Youichi

doi:10.1159/000103440

Cited by 15 publications

(3 citation statements)

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“…It is interesting to note that the location of the larger lesion with pulvi nar extention is similar to that of thalamolaminotomy by Sano et al [8,9] although the direction of the approach to the target is different. The re sults of this comparative study suggests that an extensive lesion from the CM nucleus into the pulvinar is more promising, at least for controlling intractable pain due to malignancies.…”

Section: Resultsmentioning

confidence: 56%

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Evaluation of Stereotactic Thalamotomies for Pain Relief with Reference to Pulvinar Intervention

Mayanagi¹,

Bouchard²

1976

Stereotact Funct Neurosurg

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Stereotactic thalamotomies were carried out in 51 cases of malignant tumors and 9 cases of other painful conditions. The patients were divided into two groups – those with a relatively small lesion created in the basal part of the CM nucleus and those with a larger lesion extending into the pulvinar. In total, 50% of the cases showed complete pain relief, 20% partial relief and 30% no effect. The group with pulvinar intervention showed better results, especially those with malignancies.

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Section: Resultsmentioning

confidence: 56%

“…However, the question of the most suitable struc ture in the thalamus for surgical intervention seems still controversial. The lamina medullaris interna, including the CM nucleus or the postero medial basal thalamic nuclei, have been favorite targets [4,[8][9][10]. How ever, the effectiveness of the medial pulvinar lesion has also been reported [7,11].…”

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confidence: 99%

Evaluation of Stereotactic Thalamotomies for Pain Relief with Reference to Pulvinar Intervention

Mayanagi¹,

Bouchard²

1976

Stereotact Funct Neurosurg

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“…The receptive fields of these cells, and of those responding to innocuous stimuli, are large and often bilateral, suggesting that these thalamic nuclei play little or no role in discriminative processes. Lesions involving the PO and intralaminar region, however, have been reported to relieve intractable pain in man (HASSLER 1960, MARK et al 1963, SANO 1967 and markedly attenuate pain responses in cats (MITCHELL & KAELBER 1966). In the patients, there is no apparent loss of discriminative capacity, so the effect has been attributed to a loss of the affective component of pain.…”

Section: Jvondiscriminative Systemsmentioning

confidence: 99%

Neural Mechanisms of Pain: an Overview

Casey

1982

Acta Anaesthesiol Scand

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Prolonged unit responses in thalamic reticular, ventral, and posterior nuclei following lateral hypothalamic and midbrain reticular stimulation

Keene

1975

J of Neuroscience Research

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In unanesthetized postcollicular cerveau isole rats, prolonged responses over 10 sec periods following intracranial stimulation (0.2 sec, 100 Hz, 0.5 msec. 600 muA cathodal pulses) were studied with extracellular recordings of 150 nucleus reticularis and 122 ventral and posterior thalamic units. After medial forebrain bundle (MFB) or midbrain reticular (RET) stimulation, most nucleus reticularis units showed significantly decreased firing, and the MFB and RET effects converged on 64%. None was excited. In ventral and posterior thalamus, however, long-lasting unit responses were mixed. MFB and RET stimuli elicited significantly increased firing in 17% and 20% of the units, respectively, and decreased firing in 21% and 16%, respectively. Convergence of MFB- and RET-elicited responses occurred in 25% of the cells, but none showed convergence of opposite responses which might reflect believed motivational differences between the stimuli. Similar stimuli delivered to ventral medial thalamus evoked pronounced excitation of nucleus reticularis discharge, contrasting the MFB and RET effects and confirming previous reports by others. The substantial responses elicited by MFB and RET stimuli in nucleus reticularis fulfill previously proposed criteria for definition of an arousal dimension in terms of single cell activity. The similarity of MFB and RET effects in the posterior nucleus of thalamus raises questions regarding its role in nociception.

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Functional Organization of the Internal Medullary Lamina in Man

Cited by 15 publications

References 0 publications

Evaluation of Stereotactic Thalamotomies for Pain Relief with Reference to Pulvinar Intervention

Evaluation of Stereotactic Thalamotomies for Pain Relief with Reference to Pulvinar Intervention

Neural Mechanisms of Pain: an Overview

Prolonged unit responses in thalamic reticular, ventral, and posterior nuclei following lateral hypothalamic and midbrain reticular stimulation

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