Functional Outcomes of Single-Stage Ossiculoplasty in Chronic Otitis Media With or Without Cholesteatoma*

Park, Seongbin; Lim, Kang Hyeon; Lim, Sung Jin; Park, Dong Heun; Rah, Yoon Chan; Choi, June

doi:10.5152/iao.2022.21360

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Titanium showed more favorable hearing outcomes, but it could not obtain the statistical significance in comparison with Polycel ® . 9 In the aforementioned study using BCCG, the audiological outcomes of Polycel ® and titanium were suggested. However, there also was a limitation to obtain significances in the comparison; Polycel® was implemented in 213 subjects, while titanium was only in 20.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Because it is light, easy to handle, and free of autoimmune reaction, this prosthesis is still applied in the reconstruction. [8][9][10][11] Then, in the 1990s, titanium prostheses were introduced. 12 Titanium has ferromagneticity with high biocompatibility and biostability and is useful as a sound conductor because of its light and rigid nature.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16][17][18][19] However, according to the literature comparing the 2 materials, both were effective in hearing outcome; there was no conclusion that either was particularly superior. [8][9][10]20 Factors that are known to affect the surgical outcome are the presence of stapes suprastructure, types of TM (canal wall up or down), diagnosis (COM, cholesteatoma, or congenital anomaly), the status of the middle ear mucosa, and the Eustachian tube function. [21][22][23] The determination of the graft material is important because it is the only factor that a surgeon can decide arbitrarily, whereas others have already been defined even before the reconstruction.…”

Section: Introductionmentioning

confidence: 99%

“…13 -19 However, according to the literature comparing the 2 materials, both were effective in hearing outcome; there was no conclusion that either was particularly superior. 8 -10,20…”

Section: Introductionmentioning

confidence: 99%

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Which is Better for Ossiculoplasty Following Tympanomastoidectomy: Polycel® or Titanium?

Kim

Choo

et al. 2023

Ann Otol Rhinol Laryngol

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Objectives: The purpose of this study was to compare the surgical outcomes of Polycel® and titanium in ossiculoplasty following tympanomastoidectomy (TM). Methods: A total of 221 patients underwent ossiculoplasty following TM by a single surgeon using either Polycel® or titanium as prosthesis. Hearing was tested preoperatively and postoperatively at 6 months by pure-tone audiometry. Successful surgery was defined if postoperative air-bone gap (ABG) was <20 dB, the gain in air conduction (AC) hearing was >15 dB HL, or postoperative AC was <30 dB HL. Multiple linear regression was conducted to identify the factors associated with the surgical outcomes. Results: In canal wall up mastoidectomy (CWUM), both Polycel® and titanium showed favorable successful rates if partial ossicular replacement prosthesis (PORP) was used (64.3% of Polycel® and 67.6% in titanium). If total ossicular replacement prosthesis (TORP) was used, both represented similar outcomes (54.5% of Polycel® and 75.0% in titanium). In canal wall down mastoidectomy (CWDM), significant ABG reductions were observed only in the titanium group (5.2 ± 14.7 dB of Polycel® [ P = .083] and 7.0 ± 14.2 dB of titanium [ P = .002] in PORP; 4.6 ± 13.5 dB of Polycel® [ P = .097] and 9.5 ± 11.2 dB of titanium [ P < .001] in TORP). In multivariate analysis, titanium had a positive effect on the reduction of postoperative AC thresholds (B: −4.772; 95% CI: −8.706-−0.838). Conclusions: Both Polycel® and titanium showed favorable surgical outcomes for ossiculoplasty following CWUM. Titanium prosthesis is recommended for surgery after CWDM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…13 -19 However, according to the literature comparing the 2 materials, both were effective in hearing outcome; there was no conclusion that either was particularly superior. 8 -10,20…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Which is Better for Ossiculoplasty Following Tympanomastoidectomy: Polycel® or Titanium?

Kim

Choo

et al. 2023

Ann Otol Rhinol Laryngol

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show abstract

“…This tight clinical-surgical correlation has stimulated the development of many strategies for disease eradication and hearing rehabilitation over the years, including approaches that bypass ME sound conduction [18]. On the other hand, among the surgical solutions intended to restore a mechano-acoustic coupling between the tympanic membrane and the stapes footplate, the synthetic ME prostheses still play a prominent role in modern ME otosurgery, since they mimic the natural mechanics of sound wave transmission at this level [19]. Titanium is reported to be an excellent material for synthetic ME prostheses because of its intrinsic properties: it is light, rigid, non-ferromagnetic, easy to handle during surgery, and it is a good sound wave conductor.…”

Section: Discussionmentioning

confidence: 99%

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Mosconi,

Carlotto,

Caliogna

et al. 2023

JFB

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Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular middle ear replacement prostheses, to overcome extrusion while preserving acoustic properties. This in vitro study aims to explore, for the first time in current literature, the feasibility of a biohybrid middle ear prosthesis, composed of titanium surrounded by a bone extracellular matrix as bio-coating. We have hereby studied the adhesion and proliferation of human adipose-derived mesenchymal stem cells (hASC) on titanium scaffolds in vitro. Moreover, we identified the osteogenic differentiation of hASC using an immunofluorescence assay to analyze osteoblasts’ gene expression profiles (Alp, Runx2, Col1a1, Osx, and Bglap), and we counted the presence of collagen as a marker of hASC’s ability to secrete an extracellular matrix. We utilized scanning electron microscopy to evaluate the presence of an extracellular matrix on the scaffolds. Our preliminary data demonstrated the titanium’s ability to support human adipose-derived mesenchymal stem cell colonization, proliferation, and osteoblastic differentiation, in order to obtain a biohybrid device. Our experience seems encouraging; thus, we advocate for further in vivo research to corroborate our results regarding bone transplantation.

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Conductive Hearing Loss Associates With Dementia, and Middle Ear Reconstruction Mitigates This Association: A Multinational Database Study

Urdang,

Jain,

et al. 2024

Otol Neurotol

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Objective To test the hypothesis that conductive hearing loss (CHL) is associated with dementia, and that middle ear reconstruction (MER) associates with improved outcomes for these measures in a multinational electronic health records database. Study Design Retrospective cohort study with propensity-score matching (PSM). Setting TriNetX is a research database representing about 110 million patients from the United States, Taiwan, Brazil, and India. Patients Subjects older than 50 years with no HL and any CHL (ICD-10: H90.0–2). Subjects of any age with and without any MER (CPT: 1010174). Main Outcome Measures Odds ratios (ORs) and hazard ratios with 95% confidence intervals (95% CIs) for incident dementia (ICD-10: F01, F03, G30). Results Of 103,609 patients older than 50 years experiencing any CHL, 2.74% developed dementia compared with 1.22% of 38,216,019 patients with no HL (OR, 95% CI: 2.29, 2.20–2.37). Of patients experiencing CHL, there were 39,850 who received MER. The average age was 31.3 years, with 51% female patients. A total of 343,876 control patients with CHL were identified; 39,900 patients remained in each cohort after 1:1 PSM for HL- and dementia-related risk factors. Matched risk for developing dementia among MER recipients was 0.33% compared with 0.58% in controls (OR: 0.58, 0.46–0.72). Conclusions CHL increases the odds for dementia, and MER improves the odds for incident dementia. This study represents the first population study on the topic of CHL, MER, and dementia.

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Functional Outcomes of Single-Stage Ossiculoplasty in Chronic Otitis Media With or Without Cholesteatoma*

Cited by 5 publications

References 17 publications

Which is Better for Ossiculoplasty Following Tympanomastoidectomy: Polycel® or Titanium?

Which is Better for Ossiculoplasty Following Tympanomastoidectomy: Polycel® or Titanium?

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Conductive Hearing Loss Associates With Dementia, and Middle Ear Reconstruction Mitigates This Association: A Multinational Database Study

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