Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression

Wang, B.S.; Liu, Z.; Xu, Wanfeng; Sun, Shan-Liang

doi:10.4238/2014.july.24.22

Cited by 13 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The conclusions of previous meta-analyses for this SNP and HCC susceptibility were contradictory. Some studies reported no association between rs11614913 and HCC risk [29, 30, 33] , whereas 2 recent meta-analyses published by Chen and Zhu showed that the C allele of rs11614913 may contribute to HCC susceptibility [35, 36]. Our results are consistent with those reported by Chen and Zhu.…”

Section: Discussionsupporting

confidence: 91%

“…The inconsistent results may originate from several factors including sample size, source of controls and genotype methods. Several meta-analyses have also explored the association between these 2 SNPs and HCC risk, but the results are inconsistent, while only few have focused specifically on hepatitis virus-related HCC [29-36]. Hence, we performed this updated meta-analysis to improve our understanding of the relationship between miR-146a C>G/miR-196a-2 C>T and hepatitis virus-related HCC risk, hoping to provide guidance for future studies.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, genetic variation of miRNAs may alter the maturation, expression or lead to dysfunction of these molecules and potentially contribute to hepatitis virus-related HCC risk [4, 12, 13]. A number of studies have shown that several SNPs in miRNAs including miR-146a C>G (rs2910164) and miR-196a-2 C>T (rs2910164) are linked to the predisposition for HCC [10, 11, 14-29]. However, the results of these studies are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

Tian

Wang

Zhu

et al. 2017

Aging

View full text Add to dashboard Cite

Previous studies have investigated the role of miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms in hepatocellular carcinoma (HCC) susceptibility, but the results are contradictory and few specifically studied hepatitis virus-related HCC. Therefore, we conducted a meta-analysis to evaluate the association between these two polymorphisms and hepatitis virus-related HCC risk. We performed a systematical search in EMBASE, PubMed, Web of Science, CNKI and Wanfang databases as of 25th November, 2016. Finally, we assessed 14 studies involving 3852 cases and 5275 controls. Our results suggest that rs2910164 has a significant association with increased hepatitis virus-related HCC risk in allelic, homozygous, heterozygous, and dominant models (CG+GG vs. CC: OR=1.22, 95% CI=1.06-1.39, P=0.004), particularly in Chinese and HBV-related HCC subgroups. Conversely, rs11614913 was associated with lower hepatitis virus-related HCC risk in the overall analysis under allelic (T vs. C: OR=0.85, 95% CI=0.74-0.98, P=0.02), homozygous, dominant and recessive models. Subgroup analyses showed decreased risk in Chinese, HBV- and HCV-related HCC. In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population. Further, large-scale studies including other races are required to confirm these findings.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

Tian

Wang

Zhu

et al. 2017

Aging

View full text Add to dashboard Cite

show abstract

“…A statistically significant association of mir-27a A/G with gastric cancer was seen in variant genotype [22] when stratified on the basis of age (older age) and gender (male).In case of miR-499T/C, we found 1.6 folds risk with heterozygous genotype (TC) for RCC risk, while no association was seem in other genotypes or at allelic level. In support of our study, miR-499 is found susceptible to squamous cell carcinoma of head and neck in Chinese population [23]. miR-499T/C was also associated with increased risk to HBV related HCC in Chinese population [24] In a study done in Turkish population by Akkiz et al, miR-499T/C did not played any major role in genetic susceptibility to HCC [25].…”

Section: Discussionsupporting

confidence: 68%

Genetic Variants in miRNAs Associated with Renal Cell Carcinoma (RCC) Risk: A Pilot Study in North Indian Population

et al. 2014

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) is a leading cause of cancer mortality. Characterizing miRNA expression in RCC by targeting pathways involved in the action of miRNAs, may lead to discovery of some novel prognostic as well as diagnostic biomarkers. In the present study, we aimed at finding the association of various aberrations in miRNAs to be associated with risk of RCC. In this study we selected 100 histologically confirmed RCC patients and 225 healthy unrelated controls with frequency matched age and sex. Genotyping was done by PCR-RFLP for hsa-mir146aG/C, hsa-mir-27aA/G, hsa-mir-196a2C/T, hsa-mir-499A/G. However, hsa-mir-125aG/T was genotyped by allelic discrimination Taqman Ò assay. Statistical logistic regression and genetic model was used to find out the genetic effects on the risk of RCC and interactions between polymorphism of all four miRNAs and risk factors. The SNP hsa-mir-196aC/T demonstrated significant high risk for heterozygous genotype (CT; p \ 0.001, OR = 3.206, 95 % CI 1.882-5.462) and variant genotype (TT; p = 0.021, OR = 3.57, 95 % CI 1.209-10.54). Similar pattern was seen in the dominant model (CT?TT; p \ 0.001, OR = 2.992, 95 % CI 1.798-4.978) with similar effects at allelic level, T allele (p \ 0.001, OR = 1.902, 95 % CI 1.335-2.709) also for hsa-mir196aC/T. In case of hsa-mir499T/C SNP, when the three genotypes were compared, the heterozygous genotype (TC) was found to be associated (p = 0.026, OR = 1.61, 95 % CI 1.05-2.45) with RCC risk. Whereas, hsa-mir27aA/G and hsa-mir146aC/G revealed reduced risk to RCC. Our results suggested that the hsa-mir196a2C/T and hsamir499T/C perhaps could be used as a predictive marker for RCC in North Indian population if further validated functionally with varied ethnicities.

show abstract

“…Further analysis revealed that this insertion may disrupt binding of miR-122/miR-378 to IL1A, thereby increasing expression of interleukin-1 alpha (IL-1a; ). Subsequently, several groups have investigated the relationship between this polymorphism and hepatocellular carcinoma (Du et al, 2014;Wang et al, 2014), nasopharyngeal carcinoma (Yang et al, 2011), gastric cancer (Zeng et al, 2014), papillary thyroid carcinoma (Gao et al, 2014), cervical carcinoma (Pu et al, 2014b), and epithelial ovarian cancer (Zhang et al, 2014). However, no study to date has assessed its association with CRC risk.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer

et al. 2015

View full text Add to dashboard Cite

ABSTRACT.Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism 8491 IL1A polymorphism and risk of colorectal cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 8490-8495 (2015) (rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to evaluate the effect of IL1A rs3783553 on CRC risk. CRC patients (N = 339) and healthy control subjects (N = 313) were enrolled and genomic DNA was extracted from peripheral venous blood. The IL1A rs3783553 polymorphism was genotyped using a polymerase chain reaction assay. No significant differences in IL1A rs3783553 genotype frequencies were found between CRC cases and controls in an analysis of the overall data [ins/ del vs del/del: adjusted odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.69-1.34; ins/ins vs del/del: adjusted OR = 0.71, 95%CI = 0.43-1.16; ins vs del: adjusted OR = 0.86, 95%CI = 0.69-1.09], nor when data were stratified according to clinical parameters. These findings indicate that the IL1A rs3783553 polymorphism does not constitute a risk factor for the development of CRC.

show abstract

Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression

Cited by 13 publications

References 37 publications

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

Genetic Variants in miRNAs Associated with Renal Cell Carcinoma (RCC) Risk: A Pilot Study in North Indian Population

Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer

Contact Info

Product

Resources

About