Functional properties of dually modified sago starch/κ-carrageenan films: An alternative to gelatin in pharmaceutical capsules

Oladzadabbasabadi, Nazila; Ebadi, Shokoufeh; Nafchi, Abdorreza Mohammadi; Karim, A.A.; Kiahosseini, Seyed Rahim

doi:10.1016/j.carbpol.2016.12.042

Cited by 59 publications

(23 citation statements)

References 32 publications

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“…Aiming to mimic the nanofibrous architecture of the extracellular matrix (ECM) of biological tissues, gelatin has been successfully electrospun into nanofibrous membranes. In light of its non-toxicity, biodegradability, biocompatibility, formability and low-cost commercial availability [20], gelatin has been excessively used as building block for the design of smart wound dressing and healing materials [21,22], pharmaceuticals [23], personal care [24] and food industry products [25], as well as drug delivery systems [26][27][28] and scaffolds for tissue engineering [29]. However, electrospun gelatin typically present uncontrollable water-induced swelling and dissolution, and display weak mechanical strength in the hydrated state, which substantially limit long-term fibre performance [30].…”

Section: Introductionmentioning

confidence: 99%

A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly(ɛ-caprolactone) dimethacrylate co-network by scalable free surface electrospinning

Bazbouz

Tronci

2018

Materials Science and Engineering: C

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Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. Crosslinking of electrospun fibres from gelatin is required to prevent dissolution in water, to retain the original nanofibre morphology after immersion in water, and to improve the thermal and mechanical properties, although this is still challenging to accomplish in a controlled fashion. In this study, we have investigated the scalable manufacture and structural stability in aqueous environment of a UV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES) of aqueous solutions containing vinylbenzylated gelatin and poly(ɛ-caprolactone) dimethacrylate (PCL-DMA). Vinylbenzylated gelatin was obtained via chemical functionalisation with photopolymerisable 4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase in electrospun fibres were integrated in a covalent UV-cured co-network at the molecular scale, rather than being simply physically mixed. Aqueous solutions of acetic acid (90 vol%) were employed at room temperature to dissolve gelatin-4VBC (G-4VBC) and PCL-DMA with two molar ratios between 4VBC and DMA functions, whilst viscosity, surface tension and electrical conductivity of resulting electrospinning solutions were characterised. Following successful FSES, electrospun nanofibrous samples were UV-cured using Irgacure I2959 as radical photo-initiator and 1-Heptanol as water-immiscible photo-initiator carrier, resulting in the formation of a water-insoluble, gelatin/PCL covalent co-network. Scanning electron microscopy (SEM), attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC), tensile test, as well as liquid contact angle and swelling measurements were carried out to explore the surface morphology, chemical composition, thermal and mechanical properties, wettability and water holding capacity of the nanofibrous membranes, respectively. UV-cured nanofibrous membranes did not dissolve in water and showed enhanced thermal and mechanical properties, with respect to as-spun samples, indicating the effectiveness of the photo-crosslinking reaction. In addition, UV-cured gelatin/PCL membranes displayed increased structural stability in water with respect to PCL-free samples and were highly tolerated by G292 osteosarcoma cells. These results therefore support the use of PCL-DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water-insoluble, mechanical-competent gelatin membranes for healthcare applications.

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Section: Introductionmentioning

confidence: 99%

A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly(ɛ-caprolactone) dimethacrylate co-network by scalable free surface electrospinning

Bazbouz

Tronci

2018

Materials Science and Engineering: C

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“…The other previous study shows that dually modified sago starch using hydrolyzed-hydroxypropylated add with carrageenan can increase the solubility because of the reduction of the molecular weight of starch. [32]…”

Section: Solubility Of Sago Starchmentioning

confidence: 99%

Structural and rheological properties of modified sago starch (Metroxylon sagu) using treatment of steam explosion followed by acid-hydrolyzed as an alternative to produce maltodextrin

Hartiningsih

Pranoto

Supriyanto

2020

International Journal of Food Properties

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The effects of steam explosion (SE) treatment, acid hydrolysis (AH), and the combination of steam explosion and acid hydrolysis treatment (SE+AH) on structural and rheological properties of sago starch were investigated. Steam explosion (SE) is a hydrothermal pre-treatment in high-pressure which caused the expansion of water vapor and hydrolyzing the material into low molecular weight. It is a potential method for changing the structural and functional properties by hydrolyzing the starch with low cost and environmentally friendly. Sago starch and distilled water (1:12) were added into a cylinder of SE reactor at 140°C. The slurry was exploded when the temperature reached. And then sago starch was hydrolyzed in hydrochloric acid at 50°C, 60°C, 70°C for 1, 1.5, 2 h. The solubility, dextrose equivalent, hygroscopicity, viscosity, crystallinity, and rheological properties of acid-hydrolyzed sago starches (AH) were analyzed. Steam explosion (SE) treatment increased the solubility up to 40.1%; meanwhile, the combination of SE+AH increased the solubility up to 70.8%. While the viscosity decreased with increasing degree of acid hydrolysis (i.e. from 2155 cP to 27 cP). The results showed that combination SE+AH could be an effective method to produce maltodextrin. The combination of SE+AH at 70°C for 2 h has dextrose-equivalent value was increased up to 11.97 almost similar to the dextrose equivalent of maltodextrin. It changed the morphology and decreased the crystallinity up to 9.6%. Thus, SE+AH methods could be used to modify properties of starch for a specific product such as maltodextrin.

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“…[24] and 8000 [23] + MgSO 4 Figure 3. LLE data for systems composed of PEG 300, 400, 600, 4000 [25], and 6000 [26] Figure 5 shows the effects of salting out of the cation (i.e. aluminum, magnesium, and zinc cations) in two-phase systems of PEG 300 and sulfate salts.…”

Section: Binodal Curvementioning

confidence: 99%

“…PEG and its chemical derivatives of low molecular weights differ significantly from those PEG s of higher molecular weights in their physicochemical properties, biological effects on cell permeability and their absorption and excretion, as well as their higher toxicity and possibly genotoxicity [24]. One important point of application of these systems is in complexed biopolymers for nanoencapsulation purposes [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Effects of the polymer molecular weight and type of cation on phase diagrams of polythylene glycol + sulfate salts aqueous two-phase systems

Parmoon

Nafchi

Pirdashti

2019

Hem Ind

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Phase diagrams and liquid-liquid equilibrium (LLE) data for aqueous two-phase systems (ATPSs) containing zinc sulfate, magnesium sulfate or aluminium sulfate and polyethylene glycols PEG 300, 400 and 600 have been determined at 298.15 K. It was attempted to show how the PEG molecular weight and the type of cation influence the binodal curve, tie line length (TLL) and slope of the tie line (STL). The results have shown that as the PEG molecular weight increases, the two-phase region becomes extended and the binodal curve shifts to the origin. The refractive index and density of ternary (PEG 300,400 and 600 + zinc sulfate/magnesium sulfate/aluminium sulfate + water) systems have been measured to achieve the phase composition and the tie lines. Finally, the effective excluded volume (EEV) model was applied to describe the salting-out ability of the systems. The LLE data from this research may be potentially used for recovering biological molecules like proteins.

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Functional properties of dually modified sago starch/κ-carrageenan films: An alternative to gelatin in pharmaceutical capsules

Cited by 59 publications

References 32 publications

A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly(ɛ-caprolactone) dimethacrylate co-network by scalable free surface electrospinning

A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly(ɛ-caprolactone) dimethacrylate co-network by scalable free surface electrospinning

Structural and rheological properties of modified sago starch (Metroxylon sagu) using treatment of steam explosion followed by acid-hydrolyzed as an alternative to produce maltodextrin

Effects of the polymer molecular weight and type of cation on phase diagrams of polythylene glycol + sulfate salts aqueous two-phase systems

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