Functional results after treatment of retinoblastoma

Familial retinoblastoma: fundus screening schedule impact and guideline proposal. A retrospective study

“…Other authors also reported visual acuities better than 0.5 in more than 88% of screened children. 4 Older series are not comparable, because of the frequent use of EBRT and its well-known functional complications described above compromising VA. 16,17 To our knowledge, this is the first study comparing the outcome in NS children and in children screened according to different strategies. Despite the limitations owing to the retrospective nature of the study, our standardized screening schedules tailored according to the risk and according to the genetic testing along with well-established treatment protocols based on the chemoreduction paradigm ensure comparability of the groups and thus enable to isolate the specific role of screening.…”

Risk of Cataract Extraction Among Adult Retinoblastoma Survivors

“…One of the most common adverse effects of EBRT to the orbit has been the induction of cataracts (5). Ionizing radiation has been associated with the formation of posterior subcapsular cataract (PSC) through protein superficial lens opacification (6), and time to development of a PSC has been inversely related to radiation dose (7). Other risk factors for PSC include aging, corticosteroid use, gender, ultraviolet radiation, metabolic disorders, diabetes, and hypertension, and possibly education, cigarette smoking, increased alcohol consumption, and increased body mass (8, 9).…”

“…Most previous investigations of cataracts after EBRT for Rb had relatively small sample sizes, short follow-up periods of less than 15 years, and no information on other potential risk factors resulting in large variability in risk estimates (6, 7, 10–14). This report presents long-term follow-up of one of the largest cohorts of adult Rb survivors to investigate the risk for cataract extraction associated with therapeutic exposure of ionizing radiation to the lens of the eye.…”

Electrophysiological evaluation of retinal function after systemic and superselective intra-arterial chemotherapy for retinoblastoma

“…Доказаны не-благоприятные для зрения последствия вовлечения маку-лярной области в опухолевый рост [14,15]. Но до настоя-щего времени остаются неясными масштабы последствий системной химиотерапии в отношении потери зрения, а опубликованные результаты функциональных исследова-ний неоднозначны.…”

“…Но до настоя-щего времени остаются неясными масштабы последствий системной химиотерапии в отношении потери зрения, а опубликованные результаты функциональных исследова-ний неоднозначны. Одни авторы пишут, что макулоди-строфия осложняется после химиотерапии [15], другие отмечают, что в большинстве случаев можно получить удовлетворительные результаты по остроте зрения [16][17][18][19].…”