Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy

Liu, Kuijie; Yao, Hongliang; Wen, Yu; Zhao, Hua; Zhou, Nanjiang; Lei, Sanlin; Li, Xiong

doi:10.1016/j.bbadis.2018.05.020

Cited by 61 publications

(60 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More and more studies have suggested that lncRNAs pose important impacts on tumor onset and development during the past years (Clark and Mattick, 2011; Orly and Chang, 2011; Liu et al, 2018; Xiao et al, 2018). A number of reports have also revealed some dysregulated lncRNAs that play a part in OC progression, such as lncRNA HOXD‐AS1 promoting cell proliferation and invasion of epithelial OC (Zhang et al, 2017), and lncRNA EWSAT1 promoting OC progression by regulating miR‐330‐5p expression (Fu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Long non‐coding RNAs (lncRNAs) are a group of RNA transcripts short of obvious protein‐coding capacities and are 200 bases in length (Cheetham et al, 2013). Through the past decades, increasing studies have illustrated that lncRNAs are promising biological markers in tumor development, regulating a variety of cellular functions such as proliferation, migration, invasion, and apoptosis (Clark and Mattick, 2011; Orly and Chang, 2011; Liu et al, 2018; Xiao et al, 2018). The implication of lncRNAs in OC has also been delineated by mounting reports.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

Wang

Tan

2020

Cell Biology International

View full text Add to dashboard Cite

The role of long non‐coding RNAs (lncRNAs) in tumorigenesis and development of ovarian cancer (OC) has caught the attention of scientists. UNC5B antisense RNA 1 (UNC5B‐AS1) is a newly identified carcinogenic lncRNA in thyroid papillary carcinoma, but its role in OC remains unclear. This study is proposed to investigate the function and mechanism of UNC5B‐AS1 in OC. UNC5B‐AS1 expression in OC samples was obtained from gene expression profiling interactive analysis (GEPIA) based on The Cancer Genome Atlas data. Gene expressions were detected by quantitative real‐time polymerase chain reaction (RT‐qPCR) and western blot. Biological functions of UNC5B‐AS1 were assessed by cell counting kit‐8, colony formation, and caspase‐3 analysis. GEPIA revealed the UNC5B‐AS1 upregulation in OC samples. RT‐qPCR assay confirmed the upregulation of UNC5B‐AS1 in OC cells. Functionally, depletion of UCN5B‐AS1 hindered proliferation and prompted apoptosis in OC cells. Mechanistically, we found that UNC5B‐AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N‐myc downstream regulated gene‐2 (NDRG2) promoter and epigenetically repressed NDRG2. Rescue assay indicated the participation of NDRG2 in the regulation of UNC5B‐AS1 on OC progression. Together, we first illustrated that UNC5B‐AS1 promoted OC progression by regulating the H3K27me on NDRG2 via EZH2, indicating UNC5B‐AS1 as a potential molecular target for OC treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

Wang

Tan

2020

Cell Biology International

View full text Add to dashboard Cite

show abstract

“…Therefore, the downstream target gene of miRNA is one of the important components of the ceRNA network. For example, LINC01234 inhibits GC cell proliferation mainly through mucus adsorption of miR‐204‐5p, thereby affecting the expression of miR‐204‐5p downstream target genes . There are also reports that the long non‐coding RNA NEAT1‐2 adsorbs miR‐106b‐5p through the sponge, thereby up‐regulating the expression of the ATAD2 gene in PTC to promote tumorigenesis and progression .…”

Section: Discussionmentioning

confidence: 99%

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

Cao

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Long non‐coding RNA (lncRNA) is one of the important regulators of many malignancies. However, the biological function and clinical significance of a large number of lncRNAs in gastric cancer remain unclear. Therefore, we analysed the TCGA data to find that LINC01303 is significantly up‐regulated in gastric cancer tissues. However, the biological function of LINC01303 in GC remains unknown. In our study, we found that the expression of LINC01303 was significantly higher in GC tissues than in adjacent tissues by real‐time quantitative PCR. We can significantly inhibit the malignant proliferation, migration and invasion of GC cells by silencing LINC01303 expression. In addition, LINC01303 knockdown can also inhibit GC growth in vivo. After the bioinformatics analysis, we found that LINC01303 can be used as a miR‐101‐3p sponge to competitively adsorb miR‐101‐3p with EZH2. Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR‐101‐3p activity and promotes GC progression. In summary, in this study, we demonstrated for the first time that the LINC01303/miR‐101‐3p/EZH2 axis promotes GC progression.

show abstract

“…[1][2][3] Increasing reports showed that colon adenocarcinoma has received great attention from researchers and been studied with ever more advanced molecular biology methods. [1][2][3] Increasing reports showed that colon adenocarcinoma has received great attention from researchers and been studied with ever more advanced molecular biology methods.…”

Section: Introductionmentioning

confidence: 99%

E2F1‐mediated MNX1‐AS1‐miR‐218‐5p‐SEC61A1 feedback loop contributes to the progression of colon adenocarcinoma

Wang

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

The long noncoding RNA MNX1‐AS1 has been reported to facilitate the progression of glioblastoma and ovarian cancer. Nevertheless, the biological roles and underlying mechanisms of MNX1‐AS1 in colon adenocarcinoma have not been studied until now. In the current study, MNX1‐AS1 was upregulated in colon adenocarcinoma. JASPAR prediction tool showed that E2F1 could bind to the promoter region of MNX1‐AS1. The chromatin immunoprecipitation assay and luciferase reporter assay were used to verify the interactions between MNX1‐AS1 and E2F1. Then functional assays revealed that downregulation of MNX1‐AS1 decreased cell proliferation, migration, and invasion in colon adenocarcinoma, but upregulation of E2F1 reversed the effects. Moreover, subcellular fractionation assay manifested that MNX1‐AS1 was enriched in the cytoplasm of colon adenocarcinoma cells, thus we speculated whether MNX1‐AS1 could function as a competing endogenous RNA (ceRNA) to play roles in colon adenocarcinoma. Bioinformatics analysis and luciferase reporter assay indicated that MNX1‐AS1 could sponge microRNA‐218‐5p (miR‐218‐5p). Furthermore, we discovered that SEC61A1 was downstream target of miR‐218‐5p, and MNX1‐AS1 acted as a ceRNA to upregulate the expression of SEC61A1 through sponging miR‐218‐5p. Finally, rescue assays confirmed that MNX1‐AS1 facilitated the progression of colon adenocarcinoma through regulating miR‐218‐5p/SEC61A1 axis. Taken together, we concluded that E2F1‐mediated MNX1‐AS1‐miR‐218‐5p‐SEC61A1 feedback loop contributed to the progression of colon adenocarcinoma.

show abstract

Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy

Cited by 61 publications

References 39 publications

UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

E2F1‐mediated MNX1‐AS1‐miR‐218‐5p‐SEC61A1 feedback loop contributes to the progression of colon adenocarcinoma

Contact Info

Product

Resources

About