Functional Significance of Cardiac Rehabilitation-Regulated Expression of Circulating MicroRNA-423-5p in Hypertensive Patients with Heart Failure with a Moderately Reduced Ejection Fraction

Abstract

Background Hypertension is a vital risk factor for heart failure, while cardiac rehabilitation can effectively improve cardiac function of heart failure patients. This study aimed to determine the impact of cardiac rehabilitation on microRNA-423-5p in hypertensive patients with heart failure with a moderately reduced ejection fraction. Methods Sixty hypertensive patients with heart failure with a moderately reduced ejection fraction were randomly divided into cardiac rehabilitation group and positive control group with 30 cases per group, while 30 hypertensive patients without heart failure were recruited as negative control group. The cardiac rehabilitation group and positive control group were treated with 1-month cardiac rehabilitation combined with the routine treatment and routine treatment only, respectively. The New York Heart Association classification, 6-minute walking test, and color Doppler echocardiography were adopted to detect cardiac function. Meanwhile, the expression of microRNA-423-5p and N-terminal pro-B-type natriuretic peptide was determined via Real-Time Fluorescence Quantitative PCR and electrochemiluminescence immunoassay. The diagnostic potential of microR-423-5p and N-terminal pro-B-type natriuretic peptide was assessed by ROC curve analysis and multivariate linear regression model. Results Patients in cardiac rehabilitation group displayed significantly lower expression of microR-423-5p and better results of New York Heart Association classification, 6-minute walking test, and color Doppler echocardiography than those in positive control group ( P < .05). ROC analysis showed that microR-423-5p (AUC = 0.785; 95% CI: 0.686-0.865; sensitivity = 73.33%; specificity = 73.33%) had better specificity and accuracy than N-terminal pro-B-type natriuretic peptide (AUC = 0.721; 95% CI: 0.617-0.811; sensitivity = 81.67%; specificity = 63.33%). Conclusion MicroR-423-5p was implicated in left ventricular hypertrophy and might be a potential biomarker for assessing the therapeutic effect of cardiac rehabilitation on hypertensive patients with heart failure with a moderately reduced ejection fraction.

Circulating MicroRNA-423-5p in Hypertensive Patients with Heart Failure: Correspondence

“…We would like to share ideas on the publication “Functional significance of cardiac rehabilitation-regulated expression of circulating MicroRNA-423-5p in hypertensive patients with heart failure with a moderately reduced ejection fraction.” 1 MicroR-423-5p has been linked to left ventricular hypertrophy and could be used to measure the therapeutic efficacy of cardiac rehabilitation in hypertensive patients with heart failure and a modestly reduced ejection fraction, according to Huang et al 1 Based on the current findings, we agree that microRNA-423-5p could be a valuable biomarker. We should, however, be aware of other factors that can affect the level of microRNA-423-5p.…”

Diagnostic and prognostic value of microRNA423-5p in patients with heart failure

“…In studies related to HF, the presence of the microRNA423-5p [5], along with microRNA-21 [6] and microRNA-132 [7], has been identi ed in patients. Aberrant alterations in the levels of various molecules, including microRNA423-5p, have been implicated in the initiation of myocardial cell apoptosis through the regulation of the PI3K/AKT pathway and the inhibition of O-type N-acetyl glucosyltransferase (OGT), with its expression levels being associated with cardiac rehabilitation outcomes [13]. The strong correlation of microRNA423-5p with prognosis underscores the signi cance of investigating its role in the diagnosis and prognosis of HF.…”

Value of Echocardiography and Cardiac Magnetic resonance in assessing left ventricular function in breast and gastric cancer patients after Anthracycline Chemotherapy

“…MRI is a non-invasive imaging technology that can observe various large blood vessels, pericdial disease and cardiomyopathy, such as primary cardiomyopathy, hypertension, aortic valve lesions, aneurysms, constrictive pericarditis and so on [ 12 ]. Previous studies [ 19 – 21 ] demonstrated that ECHO and cardiac MRI had equivalent values in the diagnosis of ventricular function. Liu et al [ 14 ] found a good correlation and consistency between the two methods in terms of left ventricular systolic function evaluation.…”