Functional states of antioxidant enzymatic complex of tissues of Mytillus galloprovincialis Lam. under conditions of oxidative stress

Солдатов, А. А.; Gostyukhina, O. L.; Головина, И. В.

doi:10.1134/s0022093014030028

Cited by 22 publications

(6 citation statements)

References 26 publications

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“…24 The study of diabetes as a free radical pathology began relatively recently, but, a single model for assessing the role of oxidative stress in the pathogenesis of diabetes and analysis of the effectiveness of antioxidant therapy does not yet exist. [23][24][25][26][27][28] In our experiment, under conditions of EG we have established in comparison with the following values in the control: 1) a decrease of 1.27 times the number of sperm;…”

Section: The Effect Of Five-time Treatment With Gold Nanocomposites U...mentioning

confidence: 99%

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Kaleynikova

Ukrainska

Sribna

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Given the urgency of the problem of clinical and experimental pathology of diabetes mellitus (DM) and the reproductive function disorders and their correction, the direction of research was determined in the following way: to establish the functional state of testicular cells and appendages under experimental hyperglycemia, and to assess future prospects for gold nanoparticles for clinical trials. The aims to evaluate the effect of five times treatment with gold nanocomposites (gold nanoparticles (AuNPs) in the polymer matrix D-g-PAA(PE) on male reproductive function under conditions of experimental hyperglycemia.Methods: Experiments (two series) have been conducted on 120 (60 males and 60 females) Albino white laboratory mice (weighing 25-30 gm). Experimental hyperglycemia, a model of type 2 diabetes mellitus (DM2) was reproduced by administration of nicotinamide and streptozotocin (internally peritoneally). The treatment of substances was carried out in the following way: D-g-PAA (PE) (10.00 mg/kg), D-g-PAA (PE)/AuNPs (9.78 mg/kg) in the tail vein, in 0.3 ml, once a day, five times, 2 weeks after EG induction once a day, five times.Results: it was established for the first time that there is disorder of male reproductive function under conditions of experimental hyperglycemia and five-fold treatment of gold nanocomposites (D-g-PAA(PE)/AuNPs, namely an increase in the number of abnormal sperm and a decrease in spermatids, as well as an increase in preimplantation mortality of embryos (compared to this value under experimental hyperglycemia).Conclusions: Our new data suggest that treatment with such gold nanocomposites (gold nanoparticles in D-g-PAA (PE) polymer matrix) are not critical for therapeutic use (in photodynamic chemotherapy), even in hyperglycemia when there is diabetes.

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Section: The Effect Of Five-time Treatment With Gold Nanocomposites U...mentioning

confidence: 99%

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Kaleynikova

Ukrainska

Sribna

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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show abstract

“…Los biomarcadores anteriormente mencionados se han empleado en el análisis ecotoxicológico en diferentes bivalvos, como en las almejas Tapes philippinarum (11) Anodonta cygnea (21) , Scrobicularia plana (28) , Ruditapes decussatus (46)(47)(48)75,82) ,…”

Section: Antecedentesunclassified

“…Ruditapes philippinarum (75) , Chlamys islandica (81) , Pecten jacobaeus (16) y Anadara trapezia (82) ; en mejillones Mytilus galloprovincialis (11,48,(79)(80)(81)85) , Mytilus edulis chilensis (30) , Mytilus edulis (25,27) , Mytilus californianus (26) , Perna perna (41) y en el ostión Crassostrea corteziensis (29) y Crassostrea gigas (64) .…”

Section: Antecedentesunclassified

“…En contraste en la época de invierno la actividad de GPx fue más alta en las ostras de Isla Gaviota mostrando diferencia estadísticamente significativa. Los resultados que se obtuvieron en la actividad de GPx en las muestras obtenidas en La Marina en la época de verano podrían estar relacionados con la presencia de diferentes xenobióticos (metales e HAPs) en el sitio, ya que se ha reportado en diferentes trabajos que la presencia de estos contaminantes en los ambientes acuáticos y su interacción con bivalvos causan estrés oxidante a estos organismos, activando así, mecanismos de defensa antioxidante como la actividad de GPx (48,(80)(81)(82)(83) .…”

Section: Comportamiento De Actividad Acetilcolinesterasa En éPoca De unclassified

“…De esta manera el aumento en la actividad de CAT en los organismos expuestos a contaminantes es un indicio de daño oxidante por metales, así como se ha reportado con anterioridad (47) . pueden realizar su actividad de forma independiente (48) . Lo anterior podría explicar el comportamiento de la actividad de SOD en el tejido de la branquia de los organismos experimentales del sitio La Marina.…”

Section: Comportamiento De Actividad Acetilcolinesterasa En éPoca De unclassified

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Functional states of antioxidant enzymatic complex of tissues of Mytillus galloprovincialis Lam. under conditions of oxidative stress

Cited by 22 publications

References 26 publications

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Determinación del estado de salud de dos poblaciones de Pteria sterna presentes en sitios con diferente grado de contaminación mediante la evaluación de biomarcadores bioquímicos y genéticos

Comprehensive assessments of ecological states of Songhua River using chemical analysis and bivalves as bioindicators

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