Functional TiO<sub>2</sub> nanocoral architecture for light-activated cancer chemotherapy

Yadav, Hemraj M.; Thorat, Nanasaheb D.; Yallapu, Murali M.; Tofail, Syed A. M.; Kim, Jung-Sik

doi:10.1039/c6tb02324j

Cited by 36 publications

(15 citation statements)

References 40 publications

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“…In this study, we selected DOX as the model drug to test the feasibility of Au@TiO 2 core-shell NPs as a drug delivery carrier. The conjugation was confirmed by zeta potential, UV-vis spectra and fluorescence spectra 38. The zeta potential of Au@TiO 2 core-shell NPs changed from -18.9 to -1.2 mV (Figure S4A-B) after DOX loading, indicating that the negatively charged Au@TiO 2 core-shell NPs bonded with positively charged DOX (Figure S4C).…”

Section: Resultsmentioning

confidence: 81%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO 2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy. Methods : In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO 2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO 2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO 2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn 2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs were able to provide enhanced contrast under T 1 - or T 2 -weighted magnetic resonance imaging (MRI). Results : The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs. Conclusions : As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

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Section: Resultsmentioning

confidence: 81%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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“…The developed photosensitive material demonstrated improved antimicrobial properties under UV light due to decreased size of TiO 2 NPs and therefore increased surface area and greater amount of released toxic ROS [135]. In another study, Yadav et al [136] realised the combined cancer therapy using coral-shaped TiO 2 NPs loaded with anticancer drug DOX. The increased surface area of TiO 2 NPs resulted in increased payload of DOX onto the NPs.…”

Section: Titanium Dioxide Npsmentioning

confidence: 99%

“…The increased surface area of TiO 2 NPs resulted in increased payload of DOX onto the NPs. The developed delivery systems provided synergetic cytotoxic effect in cancer MCF7 cells from the released DOX (under biological stimuli inside cells) and generation of ROS from the TiO 2 NPs (under UV-light irradiation) [136]. From clinical perspective, the photoactivation of TiO 2 NPs with UV light has several limitations, such as low tissue penetration depth [137], and UV-mediated ROS production lasts for a short time and is not enough to provide a sustained and prolonged tumour destruction [138].…”

Section: Titanium Dioxide Npsmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

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Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

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“…100 Yadav et al evaluated the biocompatibility of multimodal methoxy PEG (mPEG) TiO 2 nanocoral structures (TiO 2 NCs) for chemotherapeutic drug delivery. 101 They assessed the efficiency of these drug loaded TiO 2 NCs for tunable drug release of doxorubicin (DOX, mPEG-DOX-TiO 2 NCs) in cancer chemotherapy, especially under UV light. In vitro toxicity and drug release studies were performed by exposing L929 and MCF-7 (breast cancer cell line) cells to bare TiO 2 NCs and mPEG-DOX-TiO 2 NCs and the level of ROS production in MCF-7 cells was measured using the 5-(and-6)-chloromethyl-2,7-dichloro-dihydrofluorescein diacetate-acetyl ester (H 2 DCFDA) assay.…”

Section: Titanium Oxide Nanomaterialsmentioning

confidence: 99%

Redox-active nanomaterials for nanomedicine applications

et al. 2017

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Nanomedicine utilizes the remarkable properties of nanomaterials for the diagnosis, treatment, and prevention of disease. Many of these nanomaterials have been shown to have robust antioxidative properties, potentially functioning as strong scavengers of reactive oxygen species. Conversely, several nanomaterials have also been shown to promote the generation of reactive oxygen species, which may precipitate the onset of oxidative stress, a state that is thought to contribute to the development of a variety of adverse conditions. As such, the impacts of NMs on biological entities are often associated with and influenced by their specific redox properties. In this review, we overview several classes of nanomaterials that have been or projected to be used across a wide range of biomedical applications, with discussion focusing on their unique redox properties. Amongst the nanomaterials examined include iron, cerium, and titanium metal oxide nanoparticles, gold, silver, and selenium nanoparticles, and various nanoscale carbon allotropes such as graphene, carbon nanotubes, fullerenes, and their derivatives/variations. Principal topics of discussion include the chemical mechanisms by which the nanomaterials directly interact with biological entities and the biological cascades that are thus indirectly impacted. Selected case studies highlighting the redox properties of nanomaterials and how they affect biological responses are used to exemplify the biologically-relevant redox mechanisms for each of the described nanomaterials.

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Functional TiO₂ nanocoral architecture for light-activated cancer chemotherapy

Abstract: To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG).

Cited by 36 publications

References 40 publications

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Optically responsive delivery platforms: from the design considerations to biomedical applications

Redox-active nanomaterials for nanomedicine applications

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Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy

Abstract: To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG).

Cited by 36 publications

References 40 publications

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Optically responsive delivery platforms: from the design considerations to biomedical applications

Redox-active nanomaterials for nanomedicine applications

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Product

Resources

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Functional TiO₂ nanocoral architecture for light-activated cancer chemotherapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy