Functional Variants Associated With CMPK2 and in ASB16 Influence Bovine Digital Dermatitis

Oelschlaegel, Diana; Wensch-Dorendorf, Monika; Kopke, Grit; Jungnickel, Roswitha; Waurich, Benno; Rosner, Frank; Döpfer, Dörte; Brenig, Bertram; Swalve, Hermann H.

doi:10.3389/fgene.2022.859595

Cited by 5 publications

(2 citation statements)

References 68 publications

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“…The authors noticed IL8 expression significantly increased in the M2-M3 stages of the illness, and immunohistochemistry labeling identified keratinocytes as the source, demonstrating a critical role for keratinocytederived IL8 in the pathogenesis of DD. In the same vein, functional variants linked to the CMPK2 and ASB16 genes have been shown to affect bovine digital dermatitis [41]. Additionally, Watts et al [42] noted that beta-defensin is an important indicator of active DD.…”

Section: Discussionmentioning

confidence: 99%

New Insights on Immune and Metabolic Candidate Genes Assessing Resistance/Susceptibility to Digital Dermatitis in Italian Buffaloes (Bubalus bubalis)

Ateya

Al‐Sharif

2023

Egyptian Journal of Veterinary Sciences

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Section: Discussionmentioning

confidence: 99%

New Insights on Immune and Metabolic Candidate Genes Assessing Resistance/Susceptibility to Digital Dermatitis in Italian Buffaloes (Bubalus bubalis)

Ateya

Al‐Sharif

2023

Egyptian Journal of Veterinary Sciences

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“…Several studies identified the potential for genetic selection to decrease the susceptibility for digital dermatitis in cattle (Biemans et al, 2019b;Oelschlaegel et al, 2022). It would be interesting to investigate how these genotypes relate to the phenotypes based on recurrence of M2 lesions (type I, type II, and type III) as identified by Gomez et al (2015).…”

Section: Decreasing the Susceptibility Of The Hostmentioning

confidence: 99%

Diagnosis, treatment, and control of bovine digital dermatitis in dairy cattle

Vanhoudt¹

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This thesis focuses on the detection, prompt effective treatment, and control of digital dermatitis (DD) on dairy herds. In Chapter 2, an overview of the status quo on management of DD on dairy herds is given. In Chapter 3 we demonstrated that experienced scorers are well able to differentiate between photographs of feet affected by DD and photographs feet unaffected by DD. On the other hand, they were less able to identify specific lesion stages, including the M2 and M4 stage which are considered important stages regarding clinical impact and infection reservoir, respectively. In Chapter 4 we concluded that infrared thermography (IRT) is unlikely to be suited for automated identification of feet affected by DD due to the poor associations between maximum temperature of the plantar pastern region and the presence of M2 lesions or DD lesions in general. In Chapter 5 we demonstrated that topical treatment of active, often painful, DD lesions with a copper and zinc chelates gel (coppergel) and bandage outperformed an enzyme alginogel and bandage in M-score improvement, with the majority of lesions transitioning to the chronic, often not painful, state. In contrast, treatment with the alginogel achieved improved wound healing progress compared with the coppergel. However, neither the coppergel nor the alginogel achieved high cure rates to healthy skin. In Chapter 6 we illustrated that a standalone identification of risk factors for DD together with associated advice to control these risk factors is insufficient to decrease the prevalence of DD in dairy herds. Chapter 7 concludes this thesis with a general discussion providing a reflection on insights gained and suggestions for future research on the diagnosis, treatment, and control of digital dermatitis in dairy herds.

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Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches

Yaman,

Kişi,

Şengül

et al. 2024

Sci Rep

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Neonatal diarrhea presents a significant global challenge due to its multifactorial etiology, resulting in high morbidity and mortality rates, and substantial economic losses. While molecular-level studies on genetic resilience/susceptibility to neonatal diarrhea in farm animals are scarce, prior observations indicate promising research directions. Thus, the present study utilizes two genome-wide association approaches, pKWmEB and MLM, to explore potential links between genetic variations in innate immunity and neonatal diarrhea in Karacabey Merino lambs. Analyzing 707 lambs, including 180 cases and 527 controls, revealed an overall prevalence rate of 25.5%. The pKWmEB analysis identified 13 significant SNPs exceeding the threshold of ≥ LOD 3. Moreover, MLM detected one SNP (s61781.1) in the SLC22A8 gene (p-value, 1.85eE-7), which was co-detected by both methods. A McNemar’s test was conducted as the final assessment to identify whether there are any major effective markers among the detected SNPs. Results indicate that four markers—oar3_OAR1_122352257, OAR17_77709936.1, oar3_OAR18_17278638, and s61781.1—have a substantial impact on neonatal diarrhea prevalence (odds ratio: 2.03 to 3.10; statistical power: 0.88 to 0.99). Therefore, we propose the annotated genes harboring three of the associated markers, TIAM1, YDJC, and SLC22A8, as candidate major genes for selective breeding against neonatal diarrhea.

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Functional Variants Associated With CMPK2 and in ASB16 Influence Bovine Digital Dermatitis

Cited by 5 publications

References 68 publications

New Insights on Immune and Metabolic Candidate Genes Assessing Resistance/Susceptibility to Digital Dermatitis in Italian Buffaloes (Bubalus bubalis)

New Insights on Immune and Metabolic Candidate Genes Assessing Resistance/Susceptibility to Digital Dermatitis in Italian Buffaloes (Bubalus bubalis)

Diagnosis, treatment, and control of bovine digital dermatitis in dairy cattle

Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches

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