Functional variants in the promoter region of macrophage migration inhibitory factor rs755622 gene (MIF G173C) among patients with heart failure: Association with echocardiographic indices and disease severity

El‐Mahdy, Reham I; Saleem, Tahia H.; Essam, Osman M.; Algowhary, Magdy

doi:10.1016/j.hrtlng.2020.07.015

Cited by 5 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The included studies assessed different genetic components. Twenty-four studies involved the assessment of single-nucleotide polymorphism (SNP) [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 39 , 40 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 67 , 69 , 72 , 74 ], eight studies were on the transcriptome [ 23 , 29 , 36 , 41 , 46 , 54 , 61 , 71 ], twenty-three studied microRNA (miRNA) [ 14 , 15 , 16 , 22 , 23 , 24 , 29 , 30 , 31 , 32 , 37 , 38 , 44 , 55 , 56 , 57 , 58 , 61 , 65 , 66 , 68 , …”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four of the included studies reported the association of polymorphisms of specific genes in HF [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 39 , 40 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 67 , 69 , 72 , 74 ]. These genes included HDC [ 18 ], VDR [ 19 ], ADA [ 20 ], HRH3 [ 21 ], IL-17A/IL-17RA [ 26 ], i [ 28 ], MHRT [ 33 ], HSPB7 and FRMD4B [ 39 ], CLCNKA [ 40 ], TGFBR3 [ 42 ], TNF-α [ 47 ], IL-4 [ 48 ], IL-1 [ 49 ], IL-2 [ 50 ], IL-10 and TGF-β1 [ 51 ], KCNE1 [ 52 ], AGTR1 [ 62 ], MYBPC3 [ 63 ], MIF [ 67 ], LEP [ 69 ], AGT and ACE [ 74 ]. All of these studies involved the examination of SNPs in peripheral blood.…”

Section: Resultsmentioning

confidence: 99%

“…All of these studies involved the examination of SNPs in peripheral blood. When compared to other genetic modifications that involved the cardiac tissue, the number of samples examined in these studies was generally greater, from n = 150 [ 67 ] to n = 977,323 [ 72 ]. All of these studies have reported the allelic/genotype frequency of the SNPs under investigation.…”

Section: Resultsmentioning

confidence: 99%

“…Six of them also showed the multivariate analysis for SNPs and the risk of HF [ 18 , 20 , 21 , 26 , 28 , 52 ]. Among the included studies, seventeen studies showed the results of haplotype distribution analysis [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 47 , 48 , 49 , 50 , 51 , 62 , 63 , 67 , 69 , 74 ]. In He et al, the clinical associations of polymorphisms in HRH2 , HRH3 , DAO , and HNMT with chronic heart failure (CHF) were investigated [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were published between 2007 and 2021. Twenty-three studies were conducted in China ; ten in the United States [37][38][39][40][41][42][43][44][45][46]; five in Iran [47][48][49][50][51]; four in Italy [52][53][54][55]; three in the Netherlands [56][57][58]; three in Germany [59][60][61]; two in Taiwan [62,63]; two in Australia [64,65]; and one each in New Zealand [66], Egypt [67], Japan [68], Czech Republic [69], Ireland [70], Hong Kong [71], the United Kingdom [72], Singapore [73], and Canada [74], respectively. All of the included studies are observational cohort studies and/or genome-wide association studies (GWASs).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review

Chan

Waye

Liu

et al. 2021

IJERPH

View full text Add to dashboard Cite

Patients with heart failure (HF) often present with signs and symptoms that are often nonspecific and with a wide differential diagnosis, making diagnosis and prognosis of HF by clinical presentation alone challenging. Our knowledge on genetic diversity is rapidly evolving with high-throughput DNA sequencing technology, which makes a great potential for genetic biomarker development. The present review attempts to provide a comprehensive review on the modification of major genetic components in HF patients and to explore the potential application of these components as clinical biomarkers in the diagnosis and in monitoring the progress of HF. The literature search was conducted using six databases, resulting in the inclusion of eighteen studies in the review. The findings of these studies were summarized narratively. An appraisal of the reporting quality of the included studies was conducted using a twelve-item checklist adapted from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The findings showed that changes in genetic components in patients with HF compared to healthy controls could be noninvasive diagnostic or prognostic tools for HF with higher specificity and sensitivity in comparison with the traditional biomarkers. This review provided evidence for the potential of developing genetic biomarkers of HF.

show abstract