Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation

Abstract

With an ever-growing emphasis on sustainable synthesis, aerobic C–H activation (the use of oxygen in air to activate C−H bonds) represents a highly attractive conduit for the development of novel...

Catalyst-free photo-induced aerobic radical synthesis of lactams from N-alkenyl trichloroacetamides in 2-methyltetrahydrofuran as the radical initiator under violet light

“…6) was established in the functionalisation of ethereal-based saturated heterocycles at 80 °C. 22 On the basis of the above-mentioned experiments and our own control experiments we decided to investigate the behaviour of THF and 2-MeTHF alone under violet light. Thus, when both solvents were irradiated separately overnight, after concentration, the residue contained mainly peroxides B which NMR data were identical to those reported previously.…”

“…First, as it was reported in the literature (see ref. 22), oxygen under violet light irradiation interact with THF or 2-MeTHF to generate radical species A that acts as radical initiators 23 generating (carba-moyl)dichloromethyl radical I which evolves into radical II through cyclization.…”

A new candidate of smart drug synthesis via silver (I)-NHC complexes

“…Among these compounds, compound 3a showed the best performance against both gram-positive and gram-negative bacteria [34]. The structures of all synthesized NHC complexes were examined with spectroscopic techniques such as 1 H-NMR, 13 C-NMR [35], conductivity analysis [36], FT-IR spectra [37], elemental analysis [38], LC-Mass spectra [39], UV-vis spectra [40], TGA-DTA analysis [41] and XRD spectra [42]. Activity tests for Ag(I)-NHC complexes against grampositive and gram-negative bacteria and fungi were performed.…”

Roles of Oxygen Vacancies in CeO2 Nanostructures for Catalytic Aerobic Cyclohexane Oxidation

“…The oxidation of hydrocarbons into value-added chemical products, especially alkanes that are much more difficult to utilize without active functional groups, is of great importance in the chemical industry. − Cyclohexane oxidation is a typical hydrocarbon resource high-value utilization process, and in this process, the oxidation products including cyclohexanol, cyclohexanone (referred to as KA oil), and adipic acid are important organic intermediates for nylon-6 and nylon-66 in the nylon industry. ,− For the details of cyclohexane oxidation, the widely accepted oxidation process of cyclohexane includes the activation of cyclohexane to a cyclohexyl radical, the transition to KA oil, the further oxidation to adipic acid, and the over oxidation to glutaric acid, succinic acid, and other byproducts, as described in Scheme (b). − As a complex radical oxidation reaction, it is a great challenge to activate the C–H bond and to generate active radicals under proper conditions due to the strong and inert C–H bonds, and on the other hand, it is also an important issue to investigate in order to control the oxidation process to realize the production of target products under high selectivity and avoid over oxidations. − …”