Functionalization of mesoporous MCM-41 for the delivery of curcumin as an anti-inflammatory therapy

Atiyah, Nidhal A.; Albayati, Talib M.; Atiya, Mohammed A.

doi:10.1016/j.apt.2021.103417

Cited by 79 publications

(21 citation statements)

References 45 publications

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“…Numerous kinetic models such as the zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixon-Crowell, Peppas-Sahlin, and Weibull models were applied to examine the procedure of DOX release. , Zero‐order model: W t = W 0 + K 0 t First‐order model: log false( 100 − W false) = log ⁡ 100 − K 1 t Higuchi kinetic model: W = K H t 1 / 2 Korsmeyer‐Peppas model: W = M t / M ∞ = K K P t n Hixon‐Cromwell model: W 0 1 / 3 − W t 1 / 3 K H C t Peppas‐Sahlin: M t…”

Section: Methodsmentioning

confidence: 99%

“…To comprehensively understand this phenomenon, the wide-ranging multiplicity of mathematical kinetic models has been developed for fitting experimental data. These kinetic models epitomize the release profiles of the fractional results of the drug released versus time. , Therefore, in the study, several kinetic models were explored to understand the correlation coefficient and diffusion type governing the release of the encapsulated drug.…”

Section: Introductionmentioning

confidence: 99%

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Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Mdlovu

Juang

Lin

et al. 2023

ACS Appl. Nano Mater.

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Engineered nanomaterials have been explored for chemotherapeutic drug delivery systems toward improved therapeutic effects. In this study, magnetic nanospheres consisting of MCM-41 formed onto iron oxide nanoparticles (MIO NPs) to form MMCM with cross-linked shells of Pluronic F127 (PF) and polyethylenimine (PEI) to form (MMFPEI NSs) nanospheres were synthesized. These nanospheres were loaded with doxorubicin (DOX) anticancer drug for drug-controlled release and therapeutic efficacy evaluations in mice. Nanoscale/core–shell MMFPEI NSs were successfully formed as indicated by the TEM analysis. The microstructural analysis revealed the presence of three peaks corresponding to indexed reflections (100), (110), and (200) of MCM-41. The MMFPEI NSs displayed a pH-/thermoresponsive drug release of 84.76% under a simulated tumor microenvironment. Principally, the Peppas-Sahlin, Weibull, and Korsmeyer-Peppas models, respectively, provided the best fitting for our drug delivery system with the highest correlation degree of coefficient (R 2) and the lowest AIC. The kinetics studies for diffusion exponent indicated that the MMFPEI NSs possessed predominantly Fickian diffusion behavior. The growth retardation results of HepG2 cells showed that when compared with free DOX, the MMFPEI-DOX NSs exhibited statistically significant stronger cell inhibition efficacy at the dosages of 2, 5, and 10 μg/mL after 24 and 48 h of incubation. According to the in vivo therapeutic assessments, the tumor sizes upon inoculation with PBS, MMFPEI NSs, PBS-DOX, and MMFPEI-DOX NSs were 1302.7, 1165.6, 830.9, and 382.6 mm3, respectively. Therefore, the formulated nanospheres have great probable for drug delivery in cancer therapy to overcome the limits of traditional chemotherapy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Mdlovu

Juang

Lin

et al. 2023

ACS Appl. Nano Mater.

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“…It is a natural polyphenol exhibiting anti-inflammatory, antioxidant and anticancerogenic activity. Curcumin occurs in the rhizomes of Curcuma longa [ 40 , 108 ]. Curcumin’s effectiveness in reducing inflammation has been shown to be due to its antiplatelet, antiviral and cytoprotective activity.…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

“…With the development of the highly ordered mesoporous silica MCM-41 (Mobile Composition of Matter) in 1992, mesoporous materials have become an intense research focus [ 39 ]. MCM-41 mesoporous silica possessing organized mesoporous structure, a high degree of porosity, narrow pore size distribution, large surface area, hexagonally formed pores, controllable pore volume and biocompatibility has attracted great research interest as a carrier in drug delivery systems (DDSs) [ 40 ]. The exceptional structure of mesoporous materials enables the efficient loading of drugs and their subsequent controlled release.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz

Geszke-Moritz

2022

Pharmaceutics

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Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

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“…Clinical applications of CUR-based anticancer therapy, however, have only found limited success due to CUR’s poor bioavailability caused by its low aqueous solubility [ 3 , 4 ]. CUR-loaded nanoparticles using polymers, lipids, and inorganic materials (e.g., mesoporous silica) as inert carriers represent one of the most effective formulation strategies to enhance CUR’s solubility due to the large specific surface areas afforded by nanoparticles [ 5 , 6 , 7 , 8 ]. Besides the solubility enhancement, CUR-loaded nanoparticles are particularly attractive for anticancer therapy because of the well-known enhanced permeation and retention (EPR) effects of nanoparticles, resulting in higher drug accumulation in the tumor sites [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Lyophilization of Curcumin–Albumin Nanoplex with Sucrose as Cryoprotectant: Aqueous Reconstitution, Dissolution, Kinetic Solubility, and Physicochemical Stability

Chua

Tran

et al. 2022

IJMS

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An amorphous curcumin (CUR) and bovine serum albumin (BSA) nanoparticle complex (nanoplex) was previously developed as a promising anticancer nanotherapy. The CUR-BSA nanoplex had been characterized in its aqueous suspension form. The present work developed a dry-powder form of the CUR-BSA nanoplex by lyophilization using sucrose as a cryoprotectant. The cryoprotective activity of sucrose was examined at sucrose mass fractions of 33.33, 50.00, and 66.66% by evaluating the lyophilized nanoplex’s (1) aqueous reconstitution and (2) CUR dissolution and kinetic solubility. The physicochemical stabilizing effects of sucrose upon the nanoplex’s 30-day exposures to 40 °C and 75% relative humidity were examined from (i) aqueous reconstitution, (ii) CUR dissolution, (iii) CUR and BSA payloads, (iv) amorphous form stability, and (v) BSA’s structural integrity. The good cryoprotective activity of sucrose was evidenced by the preserved BSA’s integrity and good aqueous reconstitution, resulting in a fast CUR dissolution rate and a high kinetic solubility (≈5–9× thermodynamic solubility), similar to the nanoplex suspension. While the aqueous reconstitution, CUR dissolution, and amorphous form were minimally affected by the elevated heat and humidity exposures, the treated nanoplex exhibited a lower BSA payload (≈7–26% loss) and increased protein aggregation postexposure. The adverse effects on the BSA payload and aggregation were minimized at higher sucrose mass fractions.

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Functionalization of mesoporous MCM-41 for the delivery of curcumin as an anti-inflammatory therapy

Cited by 79 publications

References 45 publications

Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Dual pH-/Thermoresponsive Shell-Cross-Linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Lyophilization of Curcumin–Albumin Nanoplex with Sucrose as Cryoprotectant: Aqueous Reconstitution, Dissolution, Kinetic Solubility, and Physicochemical Stability

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