Functionalized alginate/chitosan biocomposites consisted of cylindrical struts and biologically designed for chitosan release

Lee, KyoungHo; Ahn, Sang-Ho; Park, Chul Hyun; Lee, Dae‐Weon; Jung, Won‐Kyo; Kim, GeunHyung

doi:10.1016/j.cap.2014.06.002

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…Apart from excellent biocompatibility, an increase in the mechanical strength of these hybrid scaffolds was observed [7]. Similar work from the same group describes the combination of differently concentrated alginate hydrogels (low concentrated as shell and higher concentrated as core) [8] or co-extrusion of alginate and chitosan [9]. Nevertheless, due to the softness of the shell material the overall stability of the respective 3D scaffolds was very limited.…”

Section: Introductionmentioning

confidence: 71%

A versatile method for combining different biopolymers in a core/shell fashion by 3D plotting to achieve mechanically robust constructs

et al. 2016

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Three-dimensional extrusion of two different biomaterials in a core/shell (c/s) fashion has gained much interest in the last couple of years as it allows for fabricating constructs with novel and interesting properties. We now demonstrate that combining high concentrated (16.7 wt%) alginate hydrogels as shell material with low concentrated, soft biopolymer hydrogels as core leads to mechanically stable and robust 3D scaffolds. Alginate, chitosan, gellan gum, gelatin and collagen hydrogels were utilized successfully as core materials-hydrogels which are too soft for 3D plotting of open-porous structures without an additional mechanical support. The respective c/s scaffolds were characterized concerning their morphology, mechanical properties and swelling behavior. It could be shown that core as well as shell part can be loaded with growth factors and that the release depends on core composition and shell thickness. Neither the plotting process nor the crosslinking with 1M CaCl denatured the proteins. When core and shell were loaded with different growth factors (VEGF and BMP-2, respectively) a dual release was achieved. Finally, live human endothelial cells were integrated in the core material, demonstrating that this new strategy can be used for bioprinting purposes as well.

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Section: Introductionmentioning

confidence: 71%

A versatile method for combining different biopolymers in a core/shell fashion by 3D plotting to achieve mechanically robust constructs

et al. 2016

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“…Another advantage of the interaction between its opposite charges is an upgrade in the mechanical strength of the developed structure formed by these two polymers 14,15 . This combination is significant for scaffold development, because while alginate offers functional groups for cellular regeneration, chitosan supports the scaffold structure 16 .…”

Section: Introductionmentioning

confidence: 99%

“…In tissue engineering, swelling ability is responsible for the polymeric matrix expansion related to scaffold morphology and cell-nutrient transmission 15,35 . The swelling ratio and the weight loss of the scaffolds produced are analyzed in Figure 5.…”

Section: Swelling Studies and Weight Lossmentioning

confidence: 99%

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

et al. 2017

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The main aim of this study was to develop scaffolds based on alginate, chitosan and hybrid fibers with and without glycerol. The scaffolds developed underwent assessments for tensile property, swelling ratio and weight loss, cellular viability, degradation and biomineralization, as well as DSC/TGA thermal analysis. Tenacity values showed that use of glycerol and the interaction between alginate and chitosan as a hybrid fiber were associated with increasing tenacity values. In the swelling and weight loss study, the scaffolds containing glycerol presented lower weight loss and higher water absorption values in all scaffolds, compared to scaffolds without glycerol, indicating that glycerol acted as a stabilizer. None of the alginate, chitosan and hybrid scaffolds, with or without glycerol, decreased cell viability. On the third day of the biomineralization assay, chitosan without glycerol indicated the presence of apatite crystals. The degradation study showed that glycerol may have acted as a stabilizer.

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“…Diversos biomateriais e técnicas de produção são estudados para utilização na engenharia de materiais, objetivando a regeneração tecidual. Algumas características são fundamentais para sua aplicabilidade in vivo, como biocompatibilidade, biodegradabilidade, scaffolds com arquitetura similar à área tratada, propriedades mecânicas favoráveis, com baixo custo de produção, para serem comercialmente viáveis (LEE et al, 2014;COX et al, 2015;SHARMA et al, 2016).…”

Section: Introductionunclassified

“…No corpo humano, a CHI é degradada por enzimas dando origem a produtos secundários não tóxicos, apresentando biocompatibilidade. A escolha de vários autores em utilizar a quitosana como base de arcabouço 3D é que esse material possui propriedades biológicas, físicas e químicas que podem ser controladas, sendo facilmente moldável (MIRANDA et al, 2011;LEE et al, 2014;SHARMA et al, 2016).…”

Section: Introductionunclassified

Technological Forecasting of Chitosan, Silk Fibroin and Xanthan Gum as Biomaterials for Scaffolds-3d

Andrade¹,

Andrade²,

Lima³

et al. 2020

RGEINTEC

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Estados Unidos detêm a maioria dos depósitos no EPO, tendo o Brasil apenas um depósito publicado. Conclui-se que, ainda que o cenário da pesquisa e desenvolvimento do Brasil venha mudando gradativamente, o volume de patentes depositadas é baixo. Além disso, foi evidenciado que scaffolds baseados em quitosana, fibroína e goma xantana possuem caráter inovador, demonstrando potencial para submissão de patente.

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Functionalized alginate/chitosan biocomposites consisted of cylindrical struts and biologically designed for chitosan release

Cited by 4 publications

References 31 publications

A versatile method for combining different biopolymers in a core/shell fashion by 3D plotting to achieve mechanically robust constructs

A versatile method for combining different biopolymers in a core/shell fashion by 3D plotting to achieve mechanically robust constructs

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

Technological Forecasting of Chitosan, Silk Fibroin and Xanthan Gum as Biomaterials for Scaffolds-3d

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