Functionalized furo[3,2-c]coumarins as anti-proliferative, anti-lipolytic, and anti-inflammatory compounds: Synthesis and molecular docking studies

Fattah, Tanzeela Abdul; Saeed, Aamer; Al‐Hiari, Yusuf; Kasabri, Violet; Almasri, Ihab M.; AlAlawi, Sundos; Larik, Fayaz Ali; Channar, Pervaiz Ali

doi:10.1016/j.molstruc.2018.11.014

Cited by 26 publications

(10 citation statements)

References 36 publications

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“…Gram positive bacteria have thick cell wall mainly composed of peptidoglycan. We do predict that due to the high lipid content in the outermembrane of Gram negative bacteria, the lipophilic FQs 3-13 (McFarland, 1907;Al-Hiari et al, 2007;Kasabri et al, 2014;Abdul Fattah et al, 2019;Arabiyat et al, 2020) are trapped in this membrane which reduces their activity. While in Gram positive bacteria they can pass the cell wall for an active cell penetration through the phospholipid bilayer membrane of Gram positive bacteria (Biagi et al, 1970).…”

Section: Antimicrobial Activitymentioning

confidence: 87%

“…It is well documented and proved by our previous work that the 4-Oxo-3-COOH contributes to any activity through chelation with di-and trivalent metals. (Kasabri et al, 2014;Arabiyat et al, 2016a,b;Kasabri et al, 2017;Alabsi et al, 2018;Jumah 2018;Abdul Fattah et al, 2019;Arabiyat et al, 2020). In addition, it provides extra number of hydrogen bond donor (Arabiyat et al 2016a,b;Alabsi et al 2018;Jumah 2018;AlShahrabi et al, 2020)…”

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confidence: 99%

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A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities

Al-Nuaimi

Al‐Hiari

Kasabri

et al. 2021

Asian Pac J Cancer Prev

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Section: Antimicrobial Activitymentioning

confidence: 87%

mentioning

confidence: 99%

A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities

Al-Nuaimi

Al‐Hiari

Kasabri

et al. 2021

Asian Pac J Cancer Prev

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“…Aldehydes also have been reported in the literature to react with two molecules of coumarin in DMSO solvent using molecular iodine (7 mol %) as catalyst at 80 °C to afford corresponding functionalized furo[3,2‐ c ]coumarins 122 in good to excellent yields (Scheme 60). [120] …”

Section: Iodine Catalyzed/mediated Multi‐component Reactionsmentioning

confidence: 99%

A Review on Molecular Iodine Catalyzed/Mediated Multicomponent Reactions

et al. 2022

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In multicomponent reactions, three or more reactants combine in one pot to form a product without the isolation of intermediate and most of the reactants contribute to newly formed product reducing number of steps involved and waste generated. Molecular iodine is mild, efficient, relatively nontoxic, inexpensive, commercially available, and catalyzes various organic reactions due to its Lewis acidic behaviour. The development of multicomponent reactions catalyzed by molecular iodine indeed is a good green alternative for synthetic organic chemistry. The aim of this article is to review all important multicomponent reactions catalyzed by molecular iodine reported since 2013 in order to envisage some new efficient protocols for the synthesis of structurally complex molecules.

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“…[1][2][3][4][5][6] Synthetic drugs and drug candidates containing these structures have demonstrated pharmacological and biological properties. [7][8][9][10] Therefore, incorporating these structural features into interesting motifs, such as pyranocoumarin, may have important implications for the design of new therapeutic agents. 4H-Pyrano [3,2-c] coumarin derivatives are an important and attractive class of pharmaceutical compounds.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent

Xie

Yang

et al. 2021

Synthesis

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4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.

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Functionalized furo[3,2-c]coumarins as anti-proliferative, anti-lipolytic, and anti-inflammatory compounds: Synthesis and molecular docking studies

Cited by 26 publications

References 36 publications

A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities

A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities

A Review on Molecular Iodine Catalyzed/Mediated Multicomponent Reactions

One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent

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