Functionalized Holmium‐Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia‐Activated Therapy

Wang, Yanke; Liu, Yan; Wu, Huixia; Zhang, Jianping; Tian, Qiwei; Yang, Shiping

doi:10.1002/adfm.201805764

Cited by 91 publications

(66 citation statements)

References 67 publications

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Section: Organic/inorganic Hybrid Sonosensitizersmentioning

confidence: 99%

“…Wang et al. fabricated holmium‐doped hollow silica nanospheres (HHSN‐C/P‐mAb) loaded with the bioreductive prodrug tirapazamine (TPZ; Figure C) . Chen et al.…”

Section: Organic/inorganic Hybrid Sonosensitizersmentioning

confidence: 99%

“…Wang et al. designed hollow silica nanospheres doped with holmium for combined SDT and hypoxia‐activated therapy …”

Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 99%

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Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Organic/inorganic Hybrid Sonosensitizersmentioning

confidence: 99%

“…Wang et al. fabricated holmium‐doped hollow silica nanospheres (HHSN‐C/P‐mAb) loaded with the bioreductive prodrug tirapazamine (TPZ; Figure C) . Chen et al.…”

Section: Organic/inorganic Hybrid Sonosensitizersmentioning

confidence: 99%

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Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…Wang et al. stellten Holmium‐dotierte hohle Siliciumdioxid‐Nanokugeln (HHSN‐C/P‐mAb) beladen mit dem bioreduzierenden Prodrug Tirapazamin (TPZ) her (Abbildung C) . Chen et al.…”

Section: Organisch‐anorganische Hybrid‐sonosensibilisatorenunclassified

Ultraschallaktivierte Sensibilisatoren

et al. 2020

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Durch Licht ausgelöste Verfahren in der Krebstherapie sind üblicherweise durch ihre geringe Penetrationstiefe limitiert. Die Sonotheranostika, insbesondere die sonodynamische Therapie (SDT), die sich von der photodynamischen Therapie (PDT) unterscheidet und hoch penetrierende Schallwellen zur Aktivierung einer Klasse von schallresponsiven Materialien verwendet, die als Sonosensibilisatoren bezeichnet werden, hat in den letzten Jahren an erheblichem Interesse gewonnen. Der Effekt der SDT hängt eng mit den strukturellen und physikochemischen Eigenschaften der Sonosensibilisatoren zusammen, was die Entwicklung von neuen schallaktivierbaren Materialien als Sonosensibilisatoren für diverse biomedizinische Anwendungen erforderlich gemacht hat. Dieser Aufsatz enthält eine Zusammenfassung und Diskussion der neuartigen Typen von Sonosensibilisatoren, die in den letzten Jahren entwickelt wurden. Anwendungen von Sonosensibilisatoren mit vielfältigen Funktionen wie Bildgebung, Wirkstofftransport und die Kombination mit anderen Behandlungsmethoden sollten neue Strategien für die Krankheitstherapie zur Verfügung stellen.

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“…Several types of hollow materials have been exploited as US contrast agents, including inorganic species (such as SiO 2 and carbon nanotubes [CNTs]) and metal/covalent organic frameworks (MOFs and COFs). Among these materials, silica is an attractive choice for biomedical imaging . US imaging applications of silica nanoparticles have been aided by numerous synthetic techniques to form particles with diverse sizes and structures, robust in vivo stability, and minimal toxicity .…”

Section: Introductionmentioning

confidence: 99%

Ultra‐Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double‐Layer Silica Nanospheres

Guo

Lyu

et al. 2019

Adv Healthcare Materials

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Timely diagnosis of acute myocardial infarction (AMI) strongly impacts the survival rate of patients. The authors report the development of a two‐shell hollow silica contrast agent useful for ultrasound (US) imaging, which is able to provide ultra‐early diagnosis of AMI. To target the characterization of fast blood flow and high blood pressure in the heart, two shells of hollow silica are adopted with opposite polarities, which assemble based on amino and perfluorodecyl silanes. The external amino silane facilitates the attachment of disease‐targeted groups, while the internal perfluorodecyl silane provides great US imaging contrast. The material also possesses superior water dispersity, controllable morphology, low toxicity, and biodegradability both in vitro and in vivo, thus promoting its applications in the ultra‐early diagnosis of AMI in rats, and is particularly useful for delineation of myocardial necrosis sites.

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Functionalized Holmium‐Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia‐Activated Therapy

Cited by 91 publications

References 67 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Ultraschallaktivierte Sensibilisatoren

Ultra‐Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double‐Layer Silica Nanospheres

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