Functionalized Hydrogels for Articular Cartilage Tissue Engineering

Zhou, Liangbin; Guo, Peng; D’Este, Matteo; Tong, Wenxue; Xu, Jiankun; Yao, Hao; Stoddart, Martin J.; Osch, Gerjo J.V.M. van; Ho, Ka; Li, Zhen; Qin, Ling

doi:10.1016/j.eng.2022.03.008

Cited by 45 publications

(23 citation statements)

References 158 publications

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“…67,68 Further combined with scaffold, MSCs-hydrogel delivery therapy has been widely studied in cartilage tissue repair. [69][70][71] Notably, the developed tissue-mimetic bioadhesives not only show the stem cell delivery capacity, but the strong local adhesion to the tissue surface also provides improved cell retention, which makes it different from existing hydrogel scaffolds in the demanding environment of the IVD. This novelty can potentially improve IVD tissue engineering efficacy.…”

Section: Esi †)mentioning

confidence: 99%

Tissue-mimetic hybrid bioadhesives for intervertebral disc repair

Liu

et al. 2023

Mater. Horiz.

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Section: Esi †)mentioning

confidence: 99%

Tissue-mimetic hybrid bioadhesives for intervertebral disc repair

Liu

et al. 2023

Mater. Horiz.

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“…To mimic the native articular hyaline cartilage ECM composition, multiple biomaterials, including natural macromolecules, synthetic polymers, and hybrid biomaterials have been applied for 3D printing of cartilage. [65][66][67][68] Thereinto, gelatin methacryloyl (GelMA), a gelatin derivative combines the biocompatibility of natural ECM with the stability, reproducibility, and modularity of synthetic biomaterials, has been widely applied for 3D printing of articular hyaline cartilage. [69] As the major component of ECM in the cartilage, gelatin also contains plenty of arginine-glycine-aspartic acid (RGD) sequences and matrix metalloproteinase (MMP) hydrolytic sequences that can promote cell adhesion and cell remodeling, respectively.…”

Section: Cartilagementioning

confidence: 99%

Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering

Wang

Zhao

et al. 2022

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The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and hierarchical organizations for translational tissue engineering remains challenging. 3D printing, an additive manufacturing technique, has revolutionized the field of tissue engineering by fabricating biomimetic tissue constructs with precisely controlled composition, spatial distribution, and architecture that can replicate both biological and functional native tissues. Therefore, 3D printing is gaining increasing attention as a viable option to advance personalized therapy for various diseases by regenerating the desired tissues. This review outlines the recently developed 3D printing techniques for clinical translation and specifically summarizes the applications of these approaches for the regeneration of cartilage, bone, and osteochondral tissues. The current challenges and future perspectives of 3D printing technology are also discussed.

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“…10 We emphasized the necessity of synergizing the entire process of bioprinting, from bioink materials, cell sources, cross-linking methods, and structural design to improved bioprinting strategies, it is essential that enable standardized control and organic integration of all aspects to achieve bionic manufacture and functionalization of engineered cartilage. 11,12…”

Section: Introductionmentioning

confidence: 99%

“…10 We emphasized the necessity of synergizing the entire process of bioprinting, from bioink materials, cell sources, crosslinking methods, and structural design to improved bioprinting strategies, it is essential that enable standardized control and organic integration of all aspects to achieve bionic manufacture and functionalization of engineered cartilage. 11,12 1.1 Function and structure of cartilage tissue Articular cartilage is a highly specialized connective tissue covering the ends of joints that serves to reduce friction and protect joints. 7 The smooth and elastic surface of articular cartilage is exposed to the synovial fluid in the joint cavity, providing a highly lubricated, wear resistant, deformable load-cush-ioning area for moving joints, which allows them to withstand the high cyclic loads.…”

Section: Introductionmentioning

confidence: 99%