Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering

Wang, Shenqiang; Zhao, Sheng; Yu, Jicheng; Gu, Zhen; Zhang, Yuqi

doi:10.1002/smll.202201869

Cited by 67 publications

(49 citation statements)

References 186 publications

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“…This 3D printed scaffold demonstrated a therapeutic approach dealing with osteoarticular lesions. A recent review on the use of 3D printing for cartilage, bone, and osteochondral regeneration provides valuable results about the effective use of such for designing and fabricating multilayered as well as graded scaffolds for the intended application …”

Section: Challenges In the Regeneration Of Osteochondral Interfacementioning

confidence: 99%

Osteochondral Interface: Regenerative Engineering and Challenges

Yıldırım

Amanzhanova

Kulzhanova

et al. 2023

ACS Biomater. Sci. Eng.

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Osteochondral (OC) defects are debilitating for patients and represent a significant clinical problem for orthopedic surgeons as well as regenerative engineers due to their potential complications, which are likely to lead to osteoarthritis and related diseases. If they remain untreated or are treated suboptimally, OC lesions are known to impact the articular cartilage and the transition from cartilage to bone, that is, the cartilage−bone interface. An important component of the OC interface, that is, a selectively permeable membrane, the tidemark, still remains unaddressed in more than 90% of the published research in the past decade. This review focuses on the structure, composition, and function of the OC interface, regenerative engineering attempts with different scaffolding strategies and challenges ahead of us in recapitulating the native OC interface. There are different schools of thought regarding the structure of the native OC interface: stratified and graded. The former assumes the cartilage-to-bone interface to be hierarchically divided into distinct yet continuous zones of uncalcified cartilage−calcified cartilage−subchondral bone. The latter assumes the interface is continuously graded, that is, formed by an infinite number of layers. The cellular composition of the interface, either in respective layers or continuously changing in a graded manner, is chondrocytes, hypertrophic chondrocytes, and osteoblasts as moved from cartilage to bone. Functionally, the interface is assumed to play a role in enabling a smooth transition of loads exerted on the cartilage surface to the bone underneath. Regenerative engineering involves, first, a characterization of the native OC interface in terms of the composition, structure, and function, and, then, proposes the appropriate biomaterials, cells, and biomolecules either alone or in combination to eventually form a structure that mimics and functionally behaves similar to the native interface. The major challenge regarding regeneration of the OC interface appears to lie, in addition to others, in the formation of tidemark, which is a thin membrane separating the OC interface into two distinct zones: the avascular OC interface and the vascular OC interface. There is a significant amount of literature on regenerative approaches to the OC interface; however, only a small portion of them consider the importance of tidemark. Therefore, this review aims at highlighting the significance of the structural organization of the components of the OC interface and increasing the awareness of the orthopedics community regarding the importance of tidemark formation after clinical interventions or regenerative engineering attempts.

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Section: Challenges In the Regeneration Of Osteochondral Interfacementioning

confidence: 99%

Osteochondral Interface: Regenerative Engineering and Challenges

Yıldırım

Amanzhanova

Kulzhanova

et al. 2023

ACS Biomater. Sci. Eng.

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“…Adapted with permission from Ref. [ 289 ]. E. Schematic of advanced extrusion-based 3D pneumatic bioprinting system affiliated with a temperature controller.…”

Section: Novel Fabrications Techniquesmentioning

confidence: 99%

“…Fig. 6 D schematically illustrates a few representative contact and noncontact 3D printing techniques that are commonly used to manufacture cellular and acellular scaffolds for tissue engineering [ 289 ]. The working principles and detailed mechanisms of these processes have been reported [ 289 , 300 , 304 , 305 ].…”

Section: Novel Fabrications Techniquesmentioning

confidence: 99%

“…6 D schematically illustrates a few representative contact and noncontact 3D printing techniques that are commonly used to manufacture cellular and acellular scaffolds for tissue engineering [ 289 ]. The working principles and detailed mechanisms of these processes have been reported [ 289 , 300 , 304 , 305 ]. Thereinto, extrusion-based printing is considered the most prevalently implemented strategy to produce cell-free or cell-laden hydrogels and scaffolds for tissue regeneration and has been gaining momentum in recent years [ 121 , 289 , [305] , [306] , [307] , [308] , [309] , [310] ].…”

Section: Novel Fabrications Techniquesmentioning

confidence: 99%

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Recent development in multizonal scaffolds for osteochondral regeneration

Cavelier

Hannon

et al. 2023

Bioactive Materials

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“…The existing bioinks only imitate the composition of ECM without appropriate geometry, resulting in unsatisfactory outcomes. [ 224 ] Bioprinted tissue lacks angiogenesis, which is crucial for supplying oxygen and nutrients, and prolonged cell survival. Thus, the majority of the tissue construct depends upon the diffusion for nutrient supply and limits the functionality of printed structures.…”

Section: Concerns and Challenges Of Photocurable 3d Printingmentioning

confidence: 99%

Recent Advances in 3D Printing of Photocurable Polymers: Types, Mechanism, and Tissue Engineering Application

Randhawa

Dutta

Ganguly

et al. 2022

Macromolecular Bioscience

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The conversion of liquid resin into solid structures upon exposure to light of a specific wavelength is known as photopolymerization. In recent years, photopolymerization‐based 3D printing has gained enormous attention for constructing complex tissue‐specific constructs. Due to the economic and environmental benefits of the biopolymers employed, photo‐curable 3D printing is considered an alternative method for replacing damaged tissues. However, the lack of suitable bio‐based photopolymers, their characterization, effective crosslinking strategies, and optimal printing conditions are hindering the extensive application of 3D printed materials in the global market. This review highlights the present status of various photopolymers, their synthesis, and their optimization parameters for biomedical applications. Moreover, a glimpse of various photopolymerization techniques currently employed for 3D printing is also discussed. Furthermore, various naturally derived nanomaterials reinforced polymerization and their influence on printability and shape fidelity are also reviewed. Finally, the ultimate use of those photopolymerized hydrogel scaffolds in tissue engineering is also discussed. Taken together, it is believed that photopolymerized 3D printing has a great future, whereas conventional 3D printing requires considerable sophistication, and this review can provide readers with a comprehensive approach to developing light‐mediated 3D printing for tissue‐engineering applications.

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Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering

Cited by 67 publications

References 186 publications

Osteochondral Interface: Regenerative Engineering and Challenges

Osteochondral Interface: Regenerative Engineering and Challenges

Recent development in multizonal scaffolds for osteochondral regeneration

Recent Advances in 3D Printing of Photocurable Polymers: Types, Mechanism, and Tissue Engineering Application

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