Recent development in multizonal scaffolds for osteochondral regeneration

Yu, Le; Cavelier, Sacha; Hannon, Brett; Wei, Mei

doi:10.1016/j.bioactmat.2023.01.012

Cited by 21 publications

(23 citation statements)

References 469 publications

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“…However, limitations exist, such as operative complications during attaining bone harvest, restricted attainable amount, further surgery, prolonged operation time, severe postoperative pain, and scarring at the harvest site leading to longer hospital stays. [5] Allogeneic bone grafts can fill larger bone defects, but their fibrous nonunion, inflammation, and microcrack propagation may raise the risk of failure after implantation. [6] Therefore, there is a contradiction between the high demand for bone grafts and the shortage and limitations of autologous and xenogeneic bone grafts.…”

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confidence: 99%

Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects. In this review article, we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair, especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli. We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment. Finally, we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds, aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.

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confidence: 99%

Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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“…However, the minimum pore size of the scaffold was less than 200 μm. While this helps resist the vascular invasion of the cartilage layer, it can also limit nutrient transport and affect cartilage repair 160 . In addition, the preparation of gradient scaffolds is complex; however, emerging technologies, such as freeze‐drying, electrospinning, and three‐dimensional printing, impose higher requirements on the properties of scaffold materials, thereby limiting their use.…”

Section: Anti‐angiogenesis Strategies In Tissue Engineeringmentioning

confidence: 99%

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies

Zhao,

Sun,

et al. 2024

The FASEB Journal

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Articular cartilage injury is one of the most common diseases in orthopedic clinics. Following an articular cartilage injury, an inability to resist vascular invasion can result in cartilage calcification by newly formed blood vessels. This process ultimately leads to the loss of joint function, significantly impacting the patient's quality of life. As a result, developing anti‐angiogenic methods to repair damaged cartilage has become a popular research topic. Despite this, tissue engineering, as an anti‐angiogenic strategy in cartilage injury repair, has not yet been adequately investigated. This exhaustive literature review mainly focused on the process and mechanism of vascular invasion in articular cartilage injury repair and summarized the major regulatory factors and signaling pathways affecting angiogenesis in the process of cartilage injury. We aimed to discuss several potential methods for engineering cartilage repair with anti‐angiogenic strategies. Three anti‐angiogenic tissue engineering methods were identified, including administering angiogenesis inhibitors, applying scaffolds to manage angiogenesis, and utilizing in vitro bioreactors to enhance the therapeutic properties of cultured chondrocytes. The advantages and disadvantages of each strategy were also analyzed. By exploring these anti‐angiogenic tissue engineering methods, we hope to provide guidance for researchers in related fields for future research and development in cartilage repair.

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“…Osteochondral defects resulting from trauma, aging, and osteoarthritis are common clinical problems that involve functional impairments of articular cartilage, subchondral bone, synovium, and ligaments. 1 Significant progress has been made in the field of tissue engineering for the repair of isolated cartilage 2,3 and bone defects. 4,5 However, the repair of osteochondral defects involves three components: cartilage, cartilage-bone interface, and subchondral bone, making achieving satisfactory repair outcomes highly challenging.…”

Section: Introductionmentioning

confidence: 99%